| Intratumor heterogeneity and branched evolution revealed by multiregion sequencing M Gerlinger, AJ Rowan, S Horswell, J Larkin, D Endesfelder, E Gronroos, ... New England journal of medicine 366 (10), 883-892, 2012 | 8536 | 2012 |
| Massive genomic rearrangement acquired in a single catastrophic event during cancer development PJ Stephens, CD Greenman, B Fu, F Yang, GR Bignell, LJ Mudie, ... cell 144 (1), 27-40, 2011 | 2585 | 2011 |
| Mutational processes molding the genomes of 21 breast cancers S Nik-Zainal, LB Alexandrov, DC Wedge, P Van Loo, CD Greenman, ... Cell 149 (5), 979-993, 2012 | 2063 | 2012 |
| A comprehensive catalogue of somatic mutations from a human cancer genome ED Pleasance, RK Cheetham, PJ Stephens, DJ McBride, SJ Humphray, ... Nature 463 (7278), 191-196, 2010 | 2015 | 2010 |
| The landscape of cancer genes and mutational processes in breast cancer PJ Stephens, PS Tarpey, H Davies, P Van Loo, C Greenman, DC Wedge, ... Nature 486 (7403), 400-404, 2012 | 1913 | 2012 |
| The patterns and dynamics of genomic instability in metastatic pancreatic cancer PJ Campbell, S Yachida, LJ Mudie, PJ Stephens, ED Pleasance, ... Nature 467 (7319), 1109-1113, 2010 | 1558 | 2010 |
| The life history of 21 breast cancers S Nik-Zainal, P Van Loo, DC Wedge, LB Alexandrov, CD Greenman, ... Cell 149 (5), 994-1007, 2012 | 1550 | 2012 |
| Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts E Papaemmanuil, M Cazzola, J Boultwood, L Malcovati, P Vyas, D Bowen, ... New England Journal of Medicine 365 (15), 1384-1395, 2011 | 1431 | 2011 |
| Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma I Varela, P Tarpey, K Raine, D Huang, CK Ong, P Stephens, H Davies, ... Nature 469 (7331), 539-542, 2011 | 1392 | 2011 |
| Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing M Gerlinger, S Horswell, J Larkin, AJ Rowan, MP Salm, I Varela, R Fisher, ... Nature genetics 46 (3), 225-233, 2014 | 1359 | 2014 |
| A small-cell lung cancer genome with complex signatures of tobacco exposure ED Pleasance, PJ Stephens, S O’Meara, DJ McBride, A Meynert, D Jones, ... Nature 463 (7278), 184-190, 2010 | 1278 | 2010 |
| Spatial and temporal diversity in genomic instability processes defines lung cancer evolution EC De Bruin, N McGranahan, R Mitter, M Salm, DC Wedge, L Yates, ... Science 346 (6206), 251-256, 2014 | 1241 | 2014 |
| Complex landscapes of somatic rearrangement in human breast cancer genomes PJ Stephens, DJ McBride, ML Lin, I Varela, ED Pleasance, JT Simpson, ... Nature 462 (7276), 1005-1010, 2009 | 1006 | 2009 |
| Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ... Nature 478 (7369), 391-394, 2011 | 815 | 2011 |
| Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation I Varela, J Cadinanos, AM Pendás, A Gutiérrez-Fernández, AR Folgueras, ... Nature 437 (7058), 564-568, 2005 | 556 | 2005 |
| Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis T McKerrell, N Park, T Moreno, CS Grove, H Ponstingl, J Stephens, ... Cell reports 10 (8), 1239-1245, 2015 | 525 | 2015 |
| Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging I Varela, S Pereira, AP Ugalde, CL Navarro, MF Suárez, P Cau, ... Nature medicine 14 (7), 767-772, 2008 | 483 | 2008 |
| Splicing-directed therapy in a new mouse model of human accelerated aging FG Osorio, CL Navarro, J Cadiñanos, IC López-Mejía, PM Quirós, ... Science translational medicine 3 (106), 106ra107-106ra107, 2011 | 445 | 2011 |
| Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes S Mueller, T Engleitner, R Maresch, M Zukowska, S Lange, ... Nature 554 (7690), 62-68, 2018 | 375 | 2018 |
| Whole exome sequencing of adenoid cystic carcinoma PJ Stephens, HR Davies, Y Mitani, P Van Loo, A Shlien, PS Tarpey, ... The Journal of clinical investigation 123 (7), 2965-2968, 2013 | 284 | 2013 |
