| Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine790→ methionine790 mutant S Chang, L Zhang, S Xu, J Luo, X Lu, Z Zhang, T Xu, Y Liu, Z Tu, Y Xu, ... Journal of Medicinal Chemistry 55 (6), 2711-2723, 2012 | 138 | 2012 |
| 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as Orally Bioavailable Transcriptional Function Suppressors of Estrogen-Related Receptor α S Xu, X Zhuang, X Pan, Z Zhang, L Duan, Y Liu, L Zhang, X Ren, K Ding Journal of Medicinal Chemistry 56 (11), 4631-4640, 2013 | 79 | 2013 |
| Design of the first‐in‐class, highly potent irreversible inhibitor targeting the menin‐MLL protein–protein interaction S Xu, A Aguilar, T Xu, K Zheng, L Huang, J Stuckey, K Chinnaswamy, ... Angewandte Chemie 130 (6), 1617-1621, 2018 | 59 | 2018 |
| Pyrimido[4,5‐d]pyrimidin‐4(1H)‐one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants T Xu, L Zhang, S Xu, CY Yang, J Luo, F Ding, X Lu, Y Liu, Z Tu, S Li, D Pei, ... Angewandte Chemie International Edition 52 (32), 8387-8390, 2013 | 35 | 2013 |
| Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor … S Xu, T Xu, L Zhang, Z Zhang, J Luo, Y Liu, X Lu, Z Tu, X Ren, K Ding Journal of medicinal chemistry 56 (21), 8803-8813, 2013 | 33 | 2013 |
| Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity S Xu, A Aguilar, L Huang, T Xu, K Zheng, D McEachern, S Przybranowski, ... Journal of medicinal chemistry 63 (9), 4997-5010, 2020 | 26 | 2020 |
| Structure-based discovery of M-89 as a highly potent inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein–protein interaction A Aguilar, K Zheng, T Xu, S Xu, L Huang, E Fernandez-Salas, L Liu, ... Journal of medicinal chemistry 62 (13), 6015-6034, 2019 | 24 | 2019 |
| Follicular lymphoma–associated BTK mutations are Inactivating resulting in augmented AKT activation N Hu, F Wang, T Sun, Z Xu, J Zhang, D Bernard, S Xu, S Wang, ... Clinical Cancer Research 27 (8), 2301-2313, 2021 | 19 | 2021 |
| Tyrosine kinase 2 (TYK2) allosteric inhibitors to treat autoimmune diseases Y Chang, S Xu, K Ding Journal of Medicinal Chemistry 62 (20), 8951-8952, 2019 | 18 | 2019 |
| Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine 790→ methionine 790 mutant S Xu, L Zhang, S Chang, J Luo, X Lu, Z Tu, Y Liu, Y Xu, X Ren, K Ding MedChemComm 3 (9), 1155-1159, 2012 | 18 | 2012 |
| Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase Y Sun, Y Zhang, X Chen, A Yu, W Du, Y Huang, F Wu, L Yu, J Li, C Wen, ... European Journal of Medicinal Chemistry 239, 114528, 2022 | 16 | 2022 |
| Structure-based discovery of a series of NSD2-PWWP1 inhibitors N Li, H Yang, K Liu, L Zhou, Y Huang, D Cao, Y Li, Y Sun, A Yu, Z Du, ... Journal of Medicinal Chemistry 65 (13), 9459-9477, 2022 | 13 | 2022 |
| Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation Z Li, X Gu, D Rao, M Lu, J Wen, X Chen, H Wang, X Cui, W Tang, S Xu, ... Translational Oncology 14 (8), 101129, 2021 | 13 | 2021 |
| Discovery of M-1121 as an orally active covalent inhibitor of menin-MLL interaction capable of achieving complete and long-lasting tumor regression M Zhang, A Aguilar, S Xu, L Huang, K Chinnaswamy, T Sleger, B Wang, ... Journal of medicinal chemistry 64 (14), 10333-10349, 2021 | 13 | 2021 |
| 1-Benzyl-4-phenyl-1H-1, 2, 3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose S Xu, L Mao, P Ding, X Zhuang, Y Zhou, L Yu, Y Liu, T Nie, T Xu, Y Xu, ... Bioorganic & Medicinal Chemistry 23 (13), 3751-3760, 2015 | 10 | 2015 |
| Discovery of 7H-Pyrrolo [2, 3-d] pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors F Wu, H Li, Q An, Y Sun, J Yu, W Cao, P Sun, X Diao, L Meng, S Xu European Journal of Medicinal Chemistry 254, 115355, 2023 | 9 | 2023 |
| Pyrimido [4, 5-d] pyrimidinyl compounds, pharmaceutical compositions and uses thereof K Ding, S Chang, S Xu, L Zhang, Z Tu, J Ding, M Geng, Y Chen US Patent App. 14/125,304, 2014 | 9 | 2014 |
| Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor D Rao, H Li, X Ren, Y Sun, C Wen, M Zheng, H Huang, W Tang, S Xu European Journal of Medicinal Chemistry 219, 113393, 2021 | 5 | 2021 |
| Discovery of a PROTAC degrader for METTL3-METTL14 complex W Du, Y Huang, X Chen, Y Deng, Y Sun, H Yang, Q Shi, F Wu, G Liu, ... Cell Chemical Biology 31 (1), 177-183. e17, 2024 | 4 | 2024 |
| Piperidines as menin inhibitors S Wang, A Aguilar, K Zheng, S Xu, T Xu, D Bernard, L Huang US Patent 10,899,738, 2021 | 3 | 2021 |
