| Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation H Van Gorp, PHV Saavedra, NM de Vasconcelos, N Van Opdenbosch, ... Proceedings of the National Academy of Sciences 113 (50), 14384-14389, 2016 | 162 | 2016 |
| GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever A Kanneganti, RKS Malireddi, PHV Saavedra, L Vande Walle, ... Journal of Experimental Medicine 215 (6), 1519-1529, 2018 | 160 | 2018 |
| Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 N Van Opdenbosch, H Van Gorp, M Verdonckt, PHV Saavedra, ... Cell reports 21 (12), 3427-3444, 2017 | 116 | 2017 |
| MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition L Vande Walle, IB Stowe, P Šácha, BL Lee, D Demon, A Fossoul, ... PLoS biology 17 (9), e3000354, 2019 | 110 | 2019 |
| Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis PHV Saavedra, L Huang, F Ghazavi, S Kourula, T Vanden Berghe, ... Nature Communications 9 (1), 4846, 2018 | 65 | 2018 |
| Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice O Dufies, A Doye, J Courjon, C Torre, G Michel, C Loubatier, A Jacquel, ... Nature microbiology 6 (3), 401-412, 2021 | 52 | 2021 |
| IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D M Kiss, L Vande Walle, PHV Saavedra, E Lebegge, H Van Damme, ... Cancer immunology research 9 (3), 309-323, 2021 | 51 | 2021 |
| Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections AC Amaral, PHV Saavedra, ACO Souza, MT de Melo, AC Tedesco, ... Colloids and Surfaces B: Biointerfaces 174, 409-415, 2019 | 49 | 2019 |
| Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever H Van Gorp, L Huang, P Saavedra, M Vuylsteke, T Asaoka, G Prencipe, ... Annals of the rheumatic diseases 79 (7), 960-968, 2020 | 42 | 2020 |
| Protective and detrimental roles of inflammasomes in disease PHV Saavedra, D Demon, H Van Gorp, M Lamkanfi Seminars in immunopathology 37, 313-322, 2015 | 33 | 2015 |
| Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments YT Wang, AJ Trzeciak, WS Rojas, P Saavedra, YT Chen, R Chirayil, ... Cell metabolism 35 (2), 316-331. e6, 2023 | 19 | 2023 |
| Immunometabolism of tissue-resident macrophages–an appraisal of the current knowledge and cutting-edge methods and technologies G Zago, PHV Saavedra, KR Keshari, JSA Perry Frontiers in Immunology 12, 665782, 2021 | 19 | 2021 |
| Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion PH Bürgel, CL Marina, PHV Saavedra, P Albuquerque, SAM De Oliveira, ... Mediators of inflammation 2020, 1-20, 2020 | 18 | 2020 |
| ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages L Wang, L Noyer, YH Wang, AY Tao, W Li, J Zhu, P Saavedra, ST Hoda, ... Journal of General Physiology 154 (10), e202213104, 2022 | 3 | 2022 |
| Gut sensor halts viral attack PHV Saavedra, M Lamkanfi Nature 546 (7660), 606-608, 2017 | 2 | 2017 |
| Differences between acapsular and encapsulated strain of Cryptococcus neoformans in NLRP3 inflammasome-dependent activation PHM Bürgel, PH Saavedra, KG Magalhaes, RJ Cordero, DS Zamboni, ... Mycoses 57, 81-82, 2014 | 2 | 2014 |
| O papel do inflamassoma na infecção induzida pelo Cryptococcus neoformans PHV Saavedra | 1 | 2013 |
| Kidney macrophages tap the stream PHV Saavedra, JSA Perry Immunity 57 (1), 3-5, 2024 | | 2024 |
| Early life high fructose exposure disrupts microglia function and impedes neurodevelopment Z Wang, A Lipschutz, ZL Liu, A Trzeciak, I Miranda, C Martinez de la Torre, ... bioRxiv, 2023.08. 14.553242, 2023 | | 2023 |
| WNK1 enforces macrophage lineage fidelity AJ Trzeciak, WS Rojas, ZL Liu, AS Krebs, Z Wang, PHV Saavedra, ... bioRxiv, 2023.04. 26.538482, 2023 | | 2023 |
Mohamed lamkanfiJanssen Pharmaceutica and Ghent UniversityVerified email at ugent.be
