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Melanie Welham
Melanie Welham
Professor, University of Bath
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p110δ, a novel phosphoinositide 3-kinase in leukocytes
B Vanhaesebroeck, MJ Welham, K Kotani, R Stein, PH Warne, ...
Proceedings of the National Academy of Sciences 94 (9), 4330-4335, 1997
6051997
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
NRD Paling, H Wheadon, HK Bone, MJ Welham
Journal of Biological Chemistry 279 (46), 48063-48070, 2004
5312004
Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing
K Wright, N Rooney, M Feeney, J Tate, D Robertson, M Welham, S Ward
Gastroenterology 129 (2), 437-453, 2005
4082005
p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.
V Duronio, MJ Welham, S Abraham, P Dryden, JW Schrader
Proceedings of the National Academy of Sciences 89 (5), 1587-1591, 1992
2561992
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
T Akasaka, T Balasas, LJ Russell, K Sugimoto, A Majid, R Walewska, ...
Blood 109 (8), 3451-3461, 2007
2332007
Interleukin-13 signal transduction in lymphohemopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin
MJ Welham, L Learmonth, H Bone, JW Schrader
Journal of Biological Chemistry 270 (20), 12286-12296, 1995
1991995
Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells
MP Storm, HK Bone, CG Beck, PY Bourillot, V Schreiber, T Damiano, ...
Journal of Biological Chemistry 282 (9), 6265-6273, 2007
1872007
Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.
MJ Welham, V Duronio, JS Sanghera, SL Pelech, JW Schrader
Journal of immunology (Baltimore, Md.: 1950) 149 (5), 1683-1693, 1992
1791992
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and …
MJ Welham, U Dechert, KB Leslie, F Jirik, JW Schrader
Journal of Biological Chemistry 269 (38), 23764-23768, 1994
1751994
Autophosphorylation of p110δ phosphoinositide 3‐kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo
B Vanhaesebroeck, K Higashi, C Raven, M Welham, S Anderson, ...
The EMBO journal, 1999
1461999
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3
HK Bone, AS Nelson, CE Goldring, D Tosh, MJ Welham
Journal of cell science 124 (12), 1992-2000, 2011
1372011
Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling
BL Craddock, EA Orchiston, HJ Hinton, MJ Welham
Journal of Biological Chemistry 274 (15), 10633-10640, 1999
1241999
Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation.
MJ Welham, V Duronio, KB Leslie, D Bowtell, JW Schrader
Journal of Biological Chemistry 269 (33), 21165-21176, 1994
1241994
The PI3K inhibitor arsenal: choose your weapon!
T Crabbe, MJ Welham, SG Ward
Trends in biochemical sciences 32 (10), 450-456, 2007
1132007
Three‐dimensional culture systems for the expansion of pluripotent embryonic stem cells
MP Storm, CB Orchard, HK Bone, JB Chaudhuri, MJ Welham
Biotechnology and bioengineering 107 (4), 683-695, 2010
1072010
Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells
HJ Hinton, MJ Welham
The Journal of Immunology 162 (12), 7002-7009, 1999
1051999
Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth.
MJ Welham, V Duronio, JW Schrader
Journal of Biological Chemistry 269 (8), 5865-5873, 1994
971994
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells
V Turinetto, L Orlando, Y Sanchez-Ripoll, B Kumpfmueller, MP Storm, ...
stem cells 30 (7), 1414-1423, 2012
932012
SHP1 and SHP2 protein-tyrosine phosphatases associate with βc after Interleukin-3-induced receptor tyrosine phosphorylation: Identification OF potential binding sites and …
H Bone, U Dechert, F Jirik, JW Schrader, MJ Welham
Journal of Biological Chemistry 272 (22), 14470-14476, 1997
911997
Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells
MJ Welham, H Bone, M Levings, L Learmonth, LM Wang, KB Leslie, ...
Journal of Biological Chemistry 272 (2), 1377-1381, 1997
811997
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