Mutagenesis of the conserved active-site tyrosine changes a retaining sialidase into an inverting sialidase JN Watson, V Dookhun, TJ Borgford, AJ Bennet Biochemistry 42 (43), 12682-12690, 2003 | 98 | 2003 |
Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations J Carrot-Zhang, G Soca-Chafre, N Patterson, AR Thorner, A Nag, ... Cancer discovery 11 (3), 591-598, 2021 | 94 | 2021 |
Structure and role of sialic acids on the surface of Aspergillus fumigatus conidiospores ML Warwas, JN Watson, AJ Bennet, MM Moore Glycobiology 17 (4), 401-410, 2007 | 70 | 2007 |
Galactose recognition by the carbohydrate-binding module of a bacterial sialidase SL Newstead, JN Watson, AJ Bennet, G Taylor Acta Crystallographica Section D: Biological Crystallography 61 (11), 1483-1491, 2005 | 59 | 2005 |
Free flap head and neck reconstruction with an emphasis on postoperative care DR van Gijn, J D'Souza, W King, M Bater Facial Plastic Surgery 34 (06), 597-604, 2018 | 44 | 2018 |
Structure and mechanism of action of an inverting mutant sialidase S Newstead, JN Watson, TL Knoll, AJ Bennet, G Taylor Biochemistry 44 (25), 9117-9122, 2005 | 37 | 2005 |
Streptomyces griseus Protease B: Secretion Correlates with the Length of the Propeptide J Baardsnes, S Sidhu, A MacLeod, J Elliott, D Morden, J Watson, ... Journal of bacteriology 180 (12), 3241-3244, 1998 | 37 | 1998 |
Chemical insight into the emergence of influenza virus strains that are resistant to Relenza FS Shidmoossavee, JN Watson, AJ Bennet Journal of the American Chemical Society 135 (36), 13254-13257, 2013 | 36 | 2013 |
Contribution of the active site aspartic acid to catalysis in the bacterial neuraminidase from Micromonospora viridifaciens JN Watson, S Newstead, V Dookhun, G Taylor, AJ Bennet FEBS letters 577 (1-2), 265-269, 2004 | 36 | 2004 |
Two Nucleophilic Mutants of the Micromonospora viridifaciens Sialidase Operate with Retention of Configuration by Two Different Mechanisms JN Watson, S Newstead, AA Narine, G Taylor, AJ Bennet Chembiochem 6 (11), 1999-2004, 2005 | 30 | 2005 |
Effect of neutral pyridine leaving groups on the mechanisms of influenza type A viral sialidase-catalyzed and spontaneous hydrolysis reactions of α-D-N-acetylneuraminides DTH Chou, JN Watson, AA Scholte, TJ Borgford, AJ Bennet Journal of the American Chemical Society 122 (35), 8357-8364, 2000 | 24 | 2000 |
Bacterial and viral sialidases: contribution of the conserved active site glutamate to catalysis J Chan, JN Watson, A Lu, VC Cerda, TJ Borgford, AJ Bennet Biochemistry 51 (1), 433-441, 2012 | 23 | 2012 |
Natural sialoside analogues for the determination of enzymatic rate constants D Indurugalla, JN Watson, AJ Bennet Organic & Biomolecular Chemistry 4 (24), 4453-4459, 2006 | 20 | 2006 |
Mechanistic requirements for the efficient enzyme-catalyzed hydrolysis of thiosialosides AA Narine, JN Watson, AJ Bennet Biochemistry 45 (30), 9319-9326, 2006 | 18 | 2006 |
The hydrolase and transferase activity of an inverting mutant sialidase using non-natural β-sialoside substrates JN Watson, D Indurugalla, LL Cheng, AA Narine, AJ Bennet Biochemistry 45 (44), 13264-13275, 2006 | 17 | 2006 |
Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastoma models with low tumor volume E Aquilanti, L Kageler, J Watson, DM Baird, RE Jones, M Hodges, ... Neuro-oncology 25 (7), 1275-1285, 2023 | 10 | 2023 |
Use of conformationally restricted pyridinium α-D-N-acetylneuraminides to probe specificity in bacterial and viral sialidases JN Watson, TL Knoll, JH Chen, DTH Chou, TJ Borgford, AJ Bennet Biochemistry and cell biology 83 (2), 115-122, 2005 | 10 | 2005 |
Brønsted analysis of an enzyme-catalyzed pseudo-deglycosylation reaction: Mechanism of desialylation in sialidases FS Shidmoossavee, L Cheng, JN Watson, AJ Bennet Biochemistry 49 (30), 6473-6484, 2010 | 8 | 2010 |
Directed evolution of a remarkably efficient Kdnase from a bacterial neuraminidase S Shamsi Kazem Abadi, MC Deen, JN Watson, FS Shidmoossavee, ... Glycobiology 30 (5), 325-333, 2020 | 3 | 2020 |
Press CW Watson US Patent 1,349,318, 1920 | 2 | 1920 |