Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo JT Heap, J Theys, M Ehsaan, AM Kubiak, L Dubois, K Paesmans, ... Oncotarget 5 (7), 1761, 2014 | 86 | 2014 |
The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy AM Kubiak, NP Minton Research in microbiology 166 (4), 244-254, 2015 | 41 | 2015 |
Efficient secretion of murine IL-2 from an attenuated strain of Clostridium sporogenes, a novel delivery vehicle for cancer immunotherapy AM Kubiak, TS Bailey, LJ Dubois, J Theys, P Lambin Frontiers in Microbiology 12, 1466, 2021 | 14 | 2021 |
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours AM Mowday, LJ Dubois, AM Kubiak, JVE Chan-Hyams, CP Guise, ... Cancer Gene Therapy 29 (2), 178-188, 2022 | 11 | 2022 |
Complete genome sequence of the nonpathogenic soil-dwelling bacterium Clostridium sporogenes strain NCIMB 10696 AM Kubiak, A Poehlein, P Budd, SA Kuehne, K Winzer, J Theys, P Lambin, ... Genome Announcements 3 (4), 10.1128/genomea. 00942-15, 2015 | 6 | 2015 |
Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications Y Zhang, TS Bailey, AM Kubiak, P Lambin, J Theys ACS Synthetic Biology 11 (11), 3817-3828, 2022 | 5 | 2022 |
Development of a CRISPR-Cas12a system for efficient genome engineering in clostridia Y Zhang, AM Kubiak, TS Bailey, L Claessen, P Hittmeyer, L Dubois, ... Microbiology spectrum 11 (6), e02459-23, 2023 | 4 | 2023 |
Refined control of CRISPR-Cas9 gene editing in Clostridium sporogenes: the creation of recombinant strains for therapeutic applications AM Kubiak, L Claessen, Y Zhang, K Khazaie, TS Bailey Frontiers in immunology 14, 1241632, 2023 | 2 | 2023 |
Clostridia as live biotherapeutics: can modified Clostridium species enhance disease treatments? AM Kubiak, J de Laak, Y Zhang, TS Bailey, L Claessen, P Hittmeyer, ... Future Microbiology, 2023 | 2 | 2023 |
Streamlined assembly of cloning and genome editing vectors for genus Clostridium TS Bailey, P Hittmeyer, Y Zhang, AM Kubiak Iscience 26 (8), 2023 | 1 | 2023 |
Genetic Engineering of Clostridial Strains for Cancer Therapy M Zygouropoulou, A Kubiak, AV Patterson, NP Minton Microbial Infections and Cancer Therapy, 73, 2019 | 1 | 2019 |
Using modified Clostridium sporogenes as a delivery vehicle for anti-cancer therapeutics P Budd, A Kubiak, M Collery, C Gustafsson, N Minton, S Kuehne Annals of Oncology 26, ii20, 2015 | 1 | 2015 |
The use of Clostridium sporogenes in directed enzyme pro-drug therapy AM Kubiak University of Nottingham, 2013 | 1 | 2013 |
Bugs as Trojan Horses to Target Necrotic Tumors AM Mowday, NG Lieuwes, R Biemans, R Gehlen, CP Guise, ... MOLECULAR THERAPY 28 (4), 508-509, 2020 | | 2020 |
Efficacy of a Novel Enzyme/Prodrug Combination for Clostridia Directed Enzyme Prodrug Therapy AM Mowday, CP Guise, AM Kubiak, NP Minton, MR Abbattista, P Lambin, ... Molecular Therapy 25 (5), 131-132, 2017 | | 2017 |
Clostridium as" Trojan Horse" Vectors for Cancer Treatment M Zygouropoulou, AM Kubiak, JN Copp, LJ Dubois, AM Mowday, ... Molecular Therapy 25 (5), 23-23, 2017 | | 2017 |