Design and evolution of enzymes for non-natural chemistry SC Hammer, AM Knight, FH Arnold Current Opinion in Green and Sustainable Chemistry 7, 23-30, 2017 | 202 | 2017 |
Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes AM Knight, SBJ Kan, RD Lewis, OF Brandenberg, K Chen, FH Arnold ACS Central Science 4 (3), 372-377, 2018 | 128 | 2018 |
Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19 JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ... ACS Central Science 7 (12), 1980-1985, 2021 | 100 | 2021 |
Stereoselective enzymatic synthesis of heteroatom-substituted cyclopropanes OF Brandenberg, CK Prier, K Chen, AM Knight, Z Wu, FH Arnold ACS Catalysis 8 (4), 2629-2634, 2018 | 95 | 2018 |
Electrostatic effect of the ribosomal surface on nascent polypeptide dynamics AM Knight, PH Culviner, N Kurt-Yilmaz, T Zou, SB Ozkan, S Cavagnero ACS chemical biology 8 (6), 1195-1204, 2013 | 87 | 2013 |
Nitrene transfer catalyzed by a non-heme iron enzyme and enhanced by non-native small-molecule ligands NW Goldberg, AM Knight, RK Zhang, FH Arnold Journal of the American Chemical Society 141 (50), 19585-19588, 2019 | 56 | 2019 |
Diversity-oriented enzymatic synthesis of cyclopropane building blocks BJ Wittmann, AM Knight, JL Hofstra, SE Reisman, SB Jennifer Kan, ... ACS catalysis 10 (13), 7112-7116, 2020 | 50 | 2020 |
Radical biocatalysis: Using non-natural single electron transfer mechanisms to access new enzymatic functions TK Hyster Synlett 31 (03), 248-254, 2020 | 42 | 2020 |
Evolving to an ideal synthesis of molnupiravir, an investigational treatment for COVID-19 T Benkovics, J McIntosh, S Silverman, J Kong, P Maligres, T Itoh, H Yang, ... | 21 | 2020 |
Intratracheal administration of recombinant human factor IX (BeneFix™) achieves therapeutic levels in hemophilia B dogs KE Russell, MS Read, DA Bellinger, K Leitermann, BJ Rup, KP McCarthy, ... Thrombosis and haemostasis 85 (03), 445-449, 2001 | 17 | 2001 |
Protoglobin‐Catalyzed Formation of cis‐Trifluoromethyl‐Substituted Cyclopropanes by Carbene Transfer L Schaus, A Das, AM Knight, G Jimenez‐Osés, KN Houk, ... Angewandte Chemie 135 (4), e202208936, 2023 | 10 | 2023 |
Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases AM Knight, A Nobili, T van den Bergh, M Genz, HJ Joosten, D Albrecht, ... Applied microbiology and biotechnology 101, 1499-1507, 2017 | 8 | 2017 |
Synthesis of 2, 3-Dihydrotryptamines from Amide Solvents and Acyclic Materials through Metal-Free Amidoalkylarylation of Unactivated Alkenes Y Ji, S Yang, S Lin, Y Wang, C Ji, Y Liu, D Liang Synlett 30 (11), 1329-1333, 2019 | 5 | 2019 |
Engineered uridine phosphorylase variant enzymes J Vroom, JA Hurtak, AM Knight US Patent 11,898,174, 2024 | 2 | 2024 |
Engineered terminal deoxynucleotidyl transferase variants C Ching, SM Forget, AM Knight, MJ Krawczyk, N Mahmoodi, MA Mayo, ... US Patent App. 18/046,451, 2023 | 1 | 2023 |
Expanding the Scope of Metalloprotein Families and Substrate Classes in New-Tonature Reactions AM Knight California Institute of Technology, 2020 | 1 | 2020 |
Engineered uridine phosphorylase variant enzymes J Vroom, JA Hurtak, AM Knight US Patent App. 18/403,265, 2024 | | 2024 |
Engineering a biocatalytic platform for modified oligonucleotide production A Knight, D Entwistle, S Forget, M Krawczyk, M Li, S Ng, N Porter, ... | | 2024 |
Engineering enzymes to produce high purity synthetic DNA A Knight, M Miller, J Vroom, C Ching, R Copeland, S Forget, M Krawczyk, ... | | 2022 |