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Ashok Mandala
Ashok Mandala
Principal Scientist
Verified email at takeda.com
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Year
Melatonin protects against lipid‐induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice
N Das, A Mandala, S Naaz, S Giri, M Jain, D Bandyopadhyay, RJ Reiter, ...
Journal of pineal research 62 (4), e12404, 2017
1572017
Heterologous priming–boosting with DNA and vaccinia virus expressing kinetoplastid membrane protein-11 induces potent cellular immune response and confers protection against …
R Guha, S Das, J Ghosh, K Naskar, A Mandala, S Sundar, JC Dujardin, ...
Vaccine 31 (15), 1905-1915, 2013
482013
Pediatric non-alcoholic fatty liver disease: nutritional origins and potential molecular mechanisms
A Mandala, RC Janssen, S Palle, KR Short, JE Friedman
Nutrients 12 (10), 3166, 2020
402020
Renal iron accelerates the progression of diabetic nephropathy in the HFE gene knockout mouse model of iron overload
K Chaudhary, A Chilakala, S Ananth, A Mandala, R Veeranan-Karmegam, ...
American Journal of Physiology-Renal Physiology 317 (2), F512-F517, 2019
342019
Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle
A Mandala, N Das, S Bhattacharjee, B Mukherjee, S Mukhopadhyay, ...
Biochemical and biophysical research communications 479 (4), 933-939, 2016
252016
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling
A Mandala, WJ Chen, A Armstrong, MR Malhotra, S Chavalmane, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 321 (3 …, 2021
192021
Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina
A Mandala, A Armstrong, B Girresch, J Zhu, A Chilakala, S Chavalmane, ...
NPJ aging and mechanisms of disease 6 (1), 12, 2020
182020
Fenofibrate reverses palmitate induced impairment in glucose uptake in skeletal muscle cells by preventing cytosolic ceramide accumulation
S Bhattacharjee, N Das, A Mandala, S Mukhopadhyay, SS Roy
Cellular Physiology and Biochemistry 37 (4), 1315-1328, 2015
162015
Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases
Austin Armstrong, Ashok Mandala, Milan Malhotra and Jaya P. Gnana-Prakasam
Oxidative Medicine and Cellular Longevity, 2022
102022
Dietary fat proportionately enhances oxidative stress and glucose intolerance followed by impaired expression of the genes associated with mitochondrial biogenesis
N Das, A Mandala, S Bhattacharjee, D Mukherjee, D Bandyopadhyay, ...
Food & function 8 (4), 1577-1586, 2017
102017
Cinnabarinic acid provides hepatoprotection against nonalcoholic fatty liver disease
NY Patil, I Rus, E Downing, A Mandala, JE Friedman, AD Joshi
Journal of Pharmacology and Experimental Therapeutics 383 (1), 32-43, 2022
92022
Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD
A Mandala, E Dobrinskikh, RC Janssen, O Fiehn, A D’Alessandro, ...
International Journal of Molecular Sciences 23 (11), 6043, 2022
32022
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
KY Sugino, A Mandala, RC Janssen, S Gurung, M Trammell, MW Day, ...
32022
1173-P: Maternally Supplemented PQQ Targets Ceramide Metabolism in Offspring to Blunt Developmental Programming of NAFLD
A MANDALA, AM TEAGUE, R JANSSEN, N PATIL, AD JOSHI, ...
Diabetes 72 (Supplement_1), 2023
2023
Short-term maternal supplementation with microbiome-derived tryptophan metabolites blunts long-term developmental programming of NAFLD in mice via altered ceramide metabolism
AM Ashok Mandala, April M. Teague, Rachel C. Janssen, Nikhil Y. Patil, Wanke ...
Reproductive Sciences 29, 222A, 2022
2022
Fenofibrate Prevents Iron Induced Activation of Canonical Wnt/β-Catenin and Oxidative Stress Signaling in the Retina
JP Gnana-Prakasam, A Mandala, A Armstrong, J Zhu
Investigative Ophthalmology & Visual Science 61 (7), 683-683, 2020
2020
Iron Regulates Canonical Wnt/β-catenin Signaling in Retina
JP Gnana-Prakasam, A Mandala
Investigative Ophthalmology & Visual Science 60 (9), 5980-5980, 2019
2019
The Molecular Mechanisms of Lipid-Induced Insulin Resistance and Its Amelioration by the Novel Anti-Diabetic Agents
A Mandala
Academy of Scientific and Innovative Research, 2017
2017
Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) 1 Gene Knockout Mouse Model of Iron Overload 2
K Chaudhary, A Chilakala, S Ananth, A Mandala, R Veeranan, ...
Cell Biology and Physiology Division 2Academy of Scientific and Innovative Research CSIR-Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Kolkata 700032, India …
DRSIBS ROY, N Das, A Mandala, S Naaz, S Giri, M Jain, ...
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