| Crystal structure of cholera toxin B‐pentamer bound to receptor GM1 pentasaccharide EA Merritt, S Sarfaty, FVD Akker, C L'Hoir, JA Martial, WGJ Hol Protein Science 3 (2), 166-175, 1994 | 745 | 1994 |
| Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux CF Bartels, H Bükülmez, P Padayatti, DK Rhee, C van Ravenswaaij-Arts, ... The American Journal of Human Genetics 75 (1), 27-34, 2004 | 401 | 2004 |
| NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism X Ma, N Sayed, A Beuve, F Van Den Akker The EMBO journal 26 (2), 578-588, 2007 | 270 | 2007 |
| Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation N Sayed, P Baskaran, X Ma, F Van Den Akker, A Beuve Proceedings of the National Academy of Sciences 104 (30), 12312-12317, 2007 | 247 | 2007 |
| Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor F van den Akker, X Zhang, M Miyagi, X Huo, KS Misono, VC Yee Nature 406 (6791), 101-104, 2000 | 171 | 2000 |
| Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases, W Ke, CR Bethel, JM Thomson, RA Bonomo, F van den Akker Biochemistry 46 (19), 5732-5740, 2007 | 164 | 2007 |
| Association of STATs with relatives and friends M Chatterjee-Kishore, F van den Akker, GR Stark Trends in cell biology 10 (3), 106-111, 2000 | 155 | 2000 |
| Strategic approaches to overcome resistance against Gram-negative pathogens using β-lactamase inhibitors and β-lactam enhancers: activity of three novel diazabicyclooctanes WCK … KM Papp-Wallace, NQ Nguyen, MR Jacobs, CR Bethel, MD Barnes, ... Journal of medicinal chemistry 61 (9), 4067-4086, 2018 | 127 | 2018 |
| Structure of cinaciguat (BAY 58–2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase F Martin, P Baskaran, X Ma, PW Dunten, M Schaefer, JP Stasch, A Beuve, ... Journal of biological chemistry 285 (29), 22651-22657, 2010 | 120 | 2010 |
| PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure X Ma, N Sayed, P Baskaran, A Beuve, F Van Den Akker Journal of biological chemistry 283 (2), 1167-1178, 2008 | 119 | 2008 |
| High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 β-lactamase PS Padayatti, MS Helfand, MA Totir, MP Carey, PR Carey, RA Bonomo, ... Journal of Biological Chemistry 280 (41), 34900-34907, 2005 | 100 | 2005 |
| Crystal structure of a new heat-labile enterotoxin, LT-IIb F van den Akker, S Sarfaty, EM Twiddy, TD Connell, RK Holmes, WGJ Hol Structure 4 (6), 665-678, 1996 | 99 | 1996 |
| AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins V Ramamurthy, M Roberts, F van den Akker, G Niemi, TA Reh, JB Hurley Proceedings of the National Academy of Sciences 100 (22), 12630-12635, 2003 | 98 | 2003 |
| Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 β-Lactamase: 1.63 Å Crystal Structure, PS Padayatti, MS Helfand, MA Totir, MP Carey, AM Hujer, PR Carey, ... Biochemistry 43 (4), 843-848, 2004 | 90 | 2004 |
| Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study NP Krishnan, NQ Nguyen, KM Papp-Wallace, RA Bonomo, ... PloS one 10 (9), e0136813, 2015 | 87 | 2015 |
| Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase X Ma, A Beuve, F Van den Akker BMC structural biology 10, 1-13, 2010 | 84 | 2010 |
| Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors F van den Akker Journal of molecular biology 311 (5), 923-937, 2001 | 80 | 2001 |
| Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent MD Barnes, V Kumar, CR Bethel, SH Moussa, J O’donnell, JD Rutter, ... MBio 10 (2), 10.1128/mbio. 00159-19, 2019 | 76 | 2019 |
| Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 … G Bou, E Santillana, A Sheri, A Beceiro, JM Sampson, M Kalp, CR Bethel, ... Journal of the American Chemical Society 132 (38), 13320-13331, 2010 | 74 | 2010 |
| Rational Design of a β-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 Å Crystal Structure of wt SHV-1 Complex with a … PS Padayatti, A Sheri, MA Totir, MS Helfand, MP Carey, VE Anderson, ... Journal of the American Chemical Society 128 (40), 13235-13242, 2006 | 69 | 2006 |
