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Sinda Lepetre
Sinda Lepetre
Maître de Conférences, Faculté de Pharmacie, Université Paris-Sud
Adresse e-mail validée de u-psud.fr
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Squalenoyl nanomedicines as potential therapeutics
P Couvreur, B Stella, LH Reddy, H Hillaireau, C Dubernet, D Desmaële, ...
Nano letters 6 (11), 2544-2548, 2006
3642006
Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury
A Gaudin, M Yemisci, H Eroglu, S Lepetre-Mouelhi, OF Turkoglu, ...
Nature nanotechnology 9 (12), 1054-1062, 2014
2402014
A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types
LH Reddy, C Dubernet, SL Mouelhi, PE Marque, D Desmaele, ...
Journal of controlled release 124 (1-2), 20-27, 2007
1532007
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue
P Couvreur, LH Reddy, S Mangenot, JH Poupaert, D Desmaële, ...
Small 4 (2), 247-253, 2008
1512008
Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
D Sobot, S Mura, SO Yesylevskyy, L Dalbin, F Cayre, G Bort, J Mougin, ...
Nature communications 8 (1), 15678, 2017
1122017
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice
LH Reddy, H Khoury, A Paci, A Deroussent, H Ferreira, C Dubernet, ...
Drug Metabolism and Disposition 36 (8), 1570-1577, 2008
1102008
Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway
L Bildstein, C Dubernet, V Marsaud, H Chacun, V Nicolas, C Gueutin, ...
Journal of controlled release 147 (2), 163-170, 2010
1082010
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine
LH Reddy, PE Marque, C Dubernet, SL Mouelhi, D Desmaele, ...
Journal of Pharmacology and Experimental Therapeutics 325 (2), 484-490, 2008
1012008
Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy
A Maksimenko, J Mougin, S Mura, E Sliwinski, E Lepeltier, C Bourgaux, ...
Cancer letters 334 (2), 346-353, 2013
832013
Novel PEGylated Nanoassemblies Made of Self‐Assembled Squalenoyl Nucleoside Analogues
F Bekkara‐Aounallah, R Gref, M Othman, LH Reddy, B Pili, V Allain, ...
Advanced functional materials 18 (22), 3715-3725, 2008
832008
Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor
LH Reddy, JM Renoir, V Marsaud, S Lepetre-Mouelhi, D Desmaële, ...
Molecular pharmaceutics 6 (5), 1526-1535, 2009
812009
A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine
J Feng, S Lepetre-Mouelhi, A Gautier, S Mura, C Cailleau, F Coudore, ...
Science advances 5 (2), eaau5148, 2019
742019
Interaction of a new anticancer prodrug, gemcitabine–squalene, with a model membrane: Coupled DSC and XRD study
B Pili, C Bourgaux, H Amenitsch, G Keller, S Lepêtre-Mouelhi, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1798 (8), 1522-1532, 2010
522010
Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues
J Caron, LH Reddy, S Lepêtre-Mouelhi, S Wack, P Clayette, ...
Bioorganic & medicinal chemistry letters 20 (9), 2761-2764, 2010
522010
Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles
E Lepeltier, C Bourgaux, V Rosilio, JH Poupaert, F Meneau, F Zouhiri, ...
Langmuir 29 (48), 14795-14803, 2013
502013
Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid− cholesterol monolayers mimicking a biomembrane
A Ambike, V Rosilio, B Stella, S Lepetre-Mouelhi, P Couvreur
Langmuir 27 (8), 4891-4899, 2011
472011
Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation
B Pili, LH Reddy, C Bourgaux, S Lepêtre-Mouelhi, D Desmaële, ...
Nanoscale 2 (8), 1521-1526, 2010
462010
Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles
F Dormont, M Rouquette, C Mahatsekake, F Gobeaux, A Peramo, ...
Journal of controlled release 307, 302-314, 2019
452019
Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms
LH Reddy, H Ferreira, C Dubernet, SL Mouelhi, D Desmaele, B Rousseau, ...
Anti-cancer drugs 19 (10), 999-1006, 2008
442008
Transport mechanisms of squalenoyl-adenosine nanoparticles across the blood–brain barrier
A Gaudin, O Tagit, D Sobot, S Lepetre-Mouelhi, J Mougin, TF Martens, ...
Chemistry of Materials 27 (10), 3636-3647, 2015
422015
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