Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis JL Nieto-Torres, ML DeDiego, C Verdiá-Báguena, JM Jimenez-Guardeño, ... PLoS pathogens 10 (5), e1004077, 2014 | 619 | 2014 |
A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo ML DeDiego, E Alvarez, F Almazán, MT Rejas, E Lamirande, A Roberts, ... Journal of virology 81 (4), 1701-1713, 2007 | 537 | 2007 |
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival ML DeDiego, JL Nieto-Torres, JA Regla-Nava, JM Jimenez-Guardeño, ... Journal of virology 88 (2), 913-924, 2014 | 437 | 2014 |
Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein JL Nieto-Torres, ML DeDiego, E Álvarez, JM Jiménez-Guardeño, ... Virology 415 (2), 69-82, 2011 | 291 | 2011 |
Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate F Almazán, ML DeDiego, I Sola, S Zuñiga, JL Nieto-Torres, ... MBio 4 (5), 10.1128/mbio. 00650-13, 2013 | 274 | 2013 |
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis JM Jimenez-Guardeño, JL Nieto-Torres, ML DeDiego, JA Regla-Nava, ... PLoS pathogens 10 (8), e1004320, 2014 | 261 | 2014 |
Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis C Castaño-Rodriguez, JM Honrubia, J Gutiérrez-Álvarez, ML DeDiego, ... MBio 9 (3), 10.1128/mbio. 02325-17, 2018 | 254 | 2018 |
Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis F Almazán, ML Dediego, C Galán, D Escors, E Alvarez, J Ortego, I Sola, ... Journal of virology 80 (21), 10900-10906, 2006 | 247 | 2006 |
Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids C Verdiá-Báguena, JL Nieto-Torres, A Alcaraz, ML DeDiego, J Torres, ... Virology 432 (2), 485-494, 2012 | 236 | 2012 |
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis ML DeDiego, JL Nieto-Torres, JM Jiménez-Guardeño, JA Regla-Nava, ... PLoS pathogens 7 (10), e1002315, 2011 | 228 | 2011 |
Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA T Tanaka, W Kamitani, ML DeDiego, L Enjuanes, Y Matsuura Journal of virology 86 (20), 11128-11137, 2012 | 223 | 2012 |
Whole-genome sequencing reveals host factors underlying critical COVID-19 A Kousathanas, E Pairo-Castineira, K Rawlik, A Stuckey, CA Odhams, ... Nature 607 (7917), 97-103, 2022 | 214 | 2022 |
Coronavirus virulence genes with main focus on SARS-CoV envelope gene ML DeDiego, JL Nieto-Torres, JM Jimenez-Guardeño, JA Regla-Nava, ... Virus research 194, 124-137, 2014 | 196 | 2014 |
Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice ML DeDiego, L Pewe, E Alvarez, MT Rejas, S Perlman, L Enjuanes Virology 376 (2), 379-389, 2008 | 178 | 2008 |
Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates JA Regla-Nava, JL Nieto-Torres, JM Jimenez-Guardeño, ... Journal of virology 89 (7), 3870-3887, 2015 | 163 | 2015 |
Identification of the mechanisms causing reversion to virulence in an attenuated SARS-CoV for the design of a genetically stable vaccine JM Jimenez-Guardeño, JA Regla-Nava, JL Nieto-Torres, ML DeDiego, ... PLoS pathogens 11 (10), e1005215, 2015 | 158 | 2015 |
Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease J Netland, ML DeDiego, J Zhao, C Fett, E Álvarez, JL Nieto-Torres, ... Virology 399 (1), 120-128, 2010 | 155 | 2010 |
Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication JA Pan, X Peng, Y Gao, Z Li, X Lu, Y Chen, M Ishaq, D Liu, ML DeDiego, ... PloS one 3 (10), e3299, 2008 | 151 | 2008 |
Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease L Enjuanes, ML DeDiego, E Alvarez, D Deming, T Sheahan, R Baric Virus research 133 (1), 45-62, 2008 | 137 | 2008 |
A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters EW Lamirande, ML DeDiego, A Roberts, JP Jackson, E Alvarez, ... Journal of virology 82 (15), 7721-7724, 2008 | 135 | 2008 |