| Amyloid beta: structure, biology and structure-based therapeutic development G Chen, TH Xu, Y Yan, Y Zhou, Y Jiang, K Melcher, HE Xu Acta Pharmacologica Sinica, 2017 | 1604 | 2017 |
| Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14 LH Zhao, XE Zhou, ZS Wu, W Yi, Y Xu, S Li, TH Xu, Y Liu, RZ Chen, ... Cell Research 23 (3), 436-439, 2013 | 266 | 2013 |
| Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex C Xing, Y Zhuang, TH Xu, Z Feng, XE Zhou, M Chen, L Wang, X Meng, ... Cell 180 (4), 645-654. e13, 2020 | 201 | 2020 |
| Structural insights into the human D1 and D2 dopamine receptor signaling complexes Y Zhuang, P Xu, C Mao, L Wang, B Krumm, XE Zhou, S Huang, H Liu, ... Cell 184 (4), 931-942. e18, 2021 | 156 | 2021 |
| Crystal structure of the Frizzled 4 receptor in a ligand-free state S Yang, Y Wu, TH Xu, PW Waal, Y He, M Pu, Y Chen, ZJ DeBruine, ... Nature, 2018 | 105 | 2018 |
| Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio TH Xu, Y Yan, Y Kang, Y Jiang, K Melcher, HE Xu Cell Discovery 2 (1), 1-14, 2016 | 101 | 2016 |
| Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling Y Zhuang, H Liu, XE Zhou, RK Verma, PW de Waal, W Jang, TH Xu, ... Nature Communications, 2020 | 93 | 2020 |
| A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex H Ma, J Duan, J Ke, Y He, X Gu, TH Xu, H Yu, Y Wang, JS Brunzelle, ... Science advances 3 (6), e1601217, 2017 | 79 | 2017 |
| Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B TH Xu, M Liu, EX Zhou, G Liang, G Zhao, EH Xu, K Melcher, PA Jones Nature 586 (7827), 151, 2020 | 68 | 2020 |
| Structure of an AMPK complex in an inactive, ATP-bound state Y Yan, S Mukherjee, KG Harikumar, TS Strutzenberg, XE Zhou, ... Science 373 (6553), 413-419, 2021 | 47 | 2021 |
| Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites Y Yan, TH Xu, G Harikumar, Kaleeckal, J Miller,Laurence, K Melcher, ... Journal of Biological Chemistry, 2017 | 37 | 2017 |
| Defining the minimum substrate and charge recognition model of gamma-secretase Y Yan, TH Xu, K Melcher, HE Xu Acta Pharmacologica Sinica 38 (10), 1412-1424, 2017 | 29 | 2017 |
| Bioluminescence Resonance Energy Transfer (BRET) Assay for Determination of Molecular Interactions in Living Cells KG Harikumar, Y Yan, TH Xu, K Melcher, HE Xu, LJ Miller bio-protocol 7 (22), 2017 | 10 | 2017 |
| Streptavidin Bead Pulldown Assay to Determine Protein Homooligomerization TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu bio-protocol 7 (22), 2017 | 5 | 2017 |
| DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding SL Thomas, TH Xu, BL Carpenter, SE Pierce, BM Dickson, M Liu, G Liang, ... Nucleic Acids Research 51 (12), 5997-6005, 2023 | 2 | 2023 |
| Detection of Membrane Protein Interactions by Cell-based Tango Assays HEX Yan Yan, Ting-Hai Xu, Kaleeckal G. Harikumar, Laurence J. Miller ... BIO-PROTOCOL 7 (22), 2017 | 2 | 2017 |
| Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation H Xuan, L Xu, K Li, F Xuan, T Xu, H Wen, X Shi Journal of Molecular Biology 436 (7), 168413, 2024 | 1 | 2024 |
| Structure of the AMPK complex in its inactive ATP-bound state Y Yan, K Melcher, S Mukherjee, KG Harikumar, TS Strutzenberg, XE Zhou, ... The Protein Society Annual Symposium 30, 187-187, 2021 | | 2021 |
| The nucleosomal acidic patch helps anchor of de novo DNA methyltransferase DNMT3A2/3B3 complex TH Xu, M Liu, E Zhou, G Liang, EH Xu, K Melcher, PA Jones Cancer Research 80 (16_Supplement), 1078-1078, 2020 | | 2020 |
| γ-Secretase Epsilon-cleavage Assay TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu bio-protocol 7 (22), 2017 | | 2017 |
Karsten MelcherVan Andel InstituteVerified email at vai.org
