| Differential desensitization, receptor phosphorylation, β-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7 TA Kohout, SL Nicholas, SJ Perry, G Reinhart, S Junger, RS Struthers Journal of Biological Chemistry 279 (22), 23214-23222, 2004 | 409 | 2004 |
| Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant RS Struthers, WW Vale, C Arias, PE Sawchenko, MR Montminy Nature 350 (6319), 622-624, 1991 | 374 | 1991 |
| Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix RS Struthers, AJ Nicholls, J Grundy, T Chen, R Jimenez, SSC Yen, ... The Journal of Clinical Endocrinology & Metabolism 94 (2), 545-551, 2009 | 148 | 2009 |
| Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1 … C Chen, D Wu, Z Guo, Q Xie, GJ Reinhart, A Madan, J Wen, T Chen, ... Journal of medicinal chemistry 51 (23), 7478-7485, 2008 | 134 | 2008 |
| Distinct conformations of the corticotropin releasing factor type 1 receptor adopted following agonist and antagonist binding are differentially regulated SJ Perry, S Junger, TA Kohout, SRJ Hoare, RS Struthers, DE Grigoriadis, ... Journal of Biological Chemistry 280 (12), 11560-11568, 2005 | 78 | 2005 |
| 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active … FC Tucci, YF Zhu, RS Struthers, Z Guo, TD Gross, MW Rowbottom, ... Journal of medicinal chemistry 48 (4), 1169-1178, 2005 | 67 | 2005 |
| Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications RP Millar, YF Zhu, RS Struthers British medical bulletin 56 (3), 761-772, 2000 | 67 | 2000 |
| Non-peptide gonadotropin-releasing hormone receptor antagonists SF Betz, YF Zhu, C Chen, RS Struthers Journal of medicinal chemistry 51 (12), 3331-3348, 2008 | 64 | 2008 |
| Activin inhibits binding of transcription factor Pit-1 to the growth hormone promoter. RS Struthers, D Gaddy-Kurten, WW Vale Proceedings of the National Academy of Sciences 89 (23), 11451-11455, 1992 | 62 | 1992 |
| Molecular Dynamics and Minimum Energy Conformations of GnRH and Analogs: A Methodology for Computer‐aided Drug Designa RS Struthers, J Rivier, AT Hagler Annals of the New York Academy of Sciences 439 (1), 81-96, 1985 | 61 | 1985 |
| Partial retro-inverso analogs of somatostatin: pairwise modifications at residues 7 and 8 and at residues 8 and 9 PV Pallai, RS Struthers, M Goodman, L Moroder, E Wunsch Biochemistry 24 (8), 1933-1941, 1985 | 57 | 1985 |
| Design of biologically active, conformationally constrained GnRH antagonists RS Struthers, G Tanaka, SC Koerber, T Solmajer, EL Baniak, LM Gierasch, ... Proteins: Structure, Function, and Bioinformatics 8 (4), 295-304, 1990 | 56 | 1990 |
| Synthesis and structure− activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists Z Guo, YF Zhu, TD Gross, FC Tucci, Y Gao, M Moorjani, PJ Connors, ... Journal of medicinal chemistry 47 (5), 1259-1271, 2004 | 52 | 2004 |
| Approaches to the synthesis of retro‐inverso peptides PV Pallai, S Richman, RS Struthers, M Goodman International Journal of Peptide and Protein Research 21 (1), 84-92, 1983 | 45 | 1983 |
| Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902 RS Struthers, Q Xie, SK Sullivan, GJ Reinhart, TA Kohout, YF Zhu, ... Endocrinology 148 (2), 857-867, 2007 | 44 | 2007 |
| Design and Structure−Activity Relationships of 2-Alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as Potent … YF Zhu, Z Guo, TD Gross, Y Gao, PJ Connors, RS Struthers, Q Xie, ... Journal of medicinal chemistry 46 (9), 1769-1772, 2003 | 44 | 2003 |
| Initial Structure–Activity Relationship Studies of a Novel Series of Pyrrolo [1, 2-a] pyrimid-7-ones as GnRH Receptor Antagonists YF Zhu, RS Struthers, PJ Connors Jr, Y Gao, TD Gross, J Saunders, ... Bioorganic & medicinal chemistry letters 12 (3), 399-402, 2002 | 44 | 2002 |
| Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor SF Betz, GJ Reinhart, FM Lio, Chen, RS Struthers Journal of medicinal chemistry 49 (2), 637-647, 2006 | 43 | 2006 |
| The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19 TR Ott, FM Lio, D Olshefski, XJ Liu, N Ling, RS Struthers Biochemical and biophysical research communications 348 (3), 1089-1093, 2006 | 42 | 2006 |
| Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure–activity relationships and insurmountable antagonism SK Sullivan, SRJ Hoare, BA Fleck, YF Zhu, CE Heise, RS Struthers, ... Biochemical pharmacology 72 (7), 838-849, 2006 | 42 | 2006 |
