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Jole Fiorito
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Synaptic therapy in Alzheimer's disease: a CREB-centric approach
AF Teich, RE Nicholls, D Puzzo, J Fiorito, R Purgatorio, O Arancio
Neurotherapeutics 12 (1), 29-41, 2015
1392015
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease
J Fiorito, F Saeed, H Zhang, A Staniszewski, Y Feng, YI Francis, S Rao, ...
European journal of medicinal chemistry 60, 285-294, 2013
1132013
Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease
E Zuccarello, E Acquarone, E Calcagno, EK Argyrousi, SX Deng, ...
Biochemical pharmacology 176, 113818, 2020
692020
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the …
J Fiorito, J Vendome, F Saeed, A Staniszewski, H Zhang, S Yan, SX Deng, ...
Journal of medicinal chemistry 60 (21), 8858-8875, 2017
512017
Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
E Acquarone, EK Argyrousi, M Van Den Berg, W Gulisano, M Fà, ...
Molecular neurodegeneration 14, 1-19, 2019
482019
PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease
AF Teich, M Sakurai, M Patel, C Holman, F Saeed, J Fiorito, O Arancio
Journal of Alzheimer's Disease 52 (1), 295-302, 2016
472016
Antiangiogenic effect of (±)-haloperidol metabolite II valproate ester [(±)-MRJF22] in human microvascular retinal endothelial cells
M Olivieri, E Amata, S Vinciguerra, J Fiorito, G Giurdanella, F Drago, ...
Journal of medicinal chemistry 59 (21), 9960-9966, 2016
422016
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells
A Marrazzo, J Fiorito, L Zappala, O Prezzavento, S Ronsisvalle, ...
European journal of medicinal chemistry 46 (1), 433-438, 2011
412011
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells
P Sozio, J Fiorito, V Di Giacomo, A Di Stefano, L Marinelli, I Cacciatore, ...
European Journal of Medicinal Chemistry 90, 1-9, 2015
372015
MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells
V Di Giacomo, V Di Valerio, M Rapino, D Bosco, I Cacciatore, M Ciulla, ...
Cellular and Molecular Biology 61 (3), 17-23, 2015
202015
Molecular mechanisms of learning and memory
D Puzzo, J Fiorito, R Purgatorio, W Gulisano, A Palmeri, O Arancio, ...
Genes, Environment and Alzheimer's Disease, 1-27, 2016
172016
Targeting the NO/cGMP/CREB phosphorylation signaling pathway in Alzheimer’s disease
J Fiorito, SX Deng, DW Landry, O Arancio
Neurochemical Basis of Brain Function and Dysfunction, 2018
72018
Strategy for overcoming Crebbp and EP300 mutations in lymphoma: Development of first-in-class HAT activators
Y Liu, J Fiorito, Y Gonzalez, B Estrella, E Calcagno, E Zuccarello, ...
Blood 134, 4068, 2019
52019
Effect of MRJF4 on C6 glioma cells proliferation and migration
S Pacella, J Fiorito, I Cacciatore, V di Giacomo, A Patruno, M Rapino, ...
Central Nervous System Agents in Medicinal Chemistry (Formerly Current …, 2017
52017
Histone acetyltransferase activators and compositions and uses thereof
OA O'connor, JE Amengual, DW Landry, O Arancio, L Scotto, S Deng, ...
US Patent 10,653,648, 2020
42020
Phosphodiesterase inhibitors and uses thereof
DW Landry, S Deng, O Arancio, J Fiorito, A Wasmuth
US Patent 10,626,113, 2020
32020
FIRST‐IN‐CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN‐HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY
Y Liu, J Fiorito, Y Gonzale, E Zuccarello, E Calcagno, JM Camarillo, ...
Hematological Oncology 37, 125-126, 2019
32019
Development of first-in-class histone acetyltransferase (HAT) activators for precision targeting of epigenetic derangements in lymphoma
Y Liu, J Fiorito, Y Gonzalez, E Zuccarello, E Calcagno, A Mazzeo, ...
Blood 132, 37, 2018
32018
Histone acetyltransferase activators and uses thereof
O Arancio, S Deng, DW Landry, J Fiorito, R Purgatorio, JE Amengual, ...
22017
Histone acetyltransferase (hat) regulators and uses thereof
O Arancio, DW Landry, S Deng, JE Amengual, E Zuccarello, J Fiorito, ...
US Patent App. 17/429,048, 2022
12022
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