Synaptic therapy in Alzheimer's disease: a CREB-centric approach AF Teich, RE Nicholls, D Puzzo, J Fiorito, R Purgatorio, O Arancio Neurotherapeutics 12 (1), 29-41, 2015 | 139 | 2015 |
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease J Fiorito, F Saeed, H Zhang, A Staniszewski, Y Feng, YI Francis, S Rao, ... European journal of medicinal chemistry 60, 285-294, 2013 | 113 | 2013 |
Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease E Zuccarello, E Acquarone, E Calcagno, EK Argyrousi, SX Deng, ... Biochemical pharmacology 176, 113818, 2020 | 69 | 2020 |
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the … J Fiorito, J Vendome, F Saeed, A Staniszewski, H Zhang, S Yan, SX Deng, ... Journal of medicinal chemistry 60 (21), 8858-8875, 2017 | 51 | 2017 |
Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade E Acquarone, EK Argyrousi, M Van Den Berg, W Gulisano, M Fà, ... Molecular neurodegeneration 14, 1-19, 2019 | 48 | 2019 |
PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease AF Teich, M Sakurai, M Patel, C Holman, F Saeed, J Fiorito, O Arancio Journal of Alzheimer's Disease 52 (1), 295-302, 2016 | 47 | 2016 |
Antiangiogenic effect of (±)-haloperidol metabolite II valproate ester [(±)-MRJF22] in human microvascular retinal endothelial cells M Olivieri, E Amata, S Vinciguerra, J Fiorito, G Giurdanella, F Drago, ... Journal of medicinal chemistry 59 (21), 9960-9966, 2016 | 42 | 2016 |
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells A Marrazzo, J Fiorito, L Zappala, O Prezzavento, S Ronsisvalle, ... European journal of medicinal chemistry 46 (1), 433-438, 2011 | 41 | 2011 |
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells P Sozio, J Fiorito, V Di Giacomo, A Di Stefano, L Marinelli, I Cacciatore, ... European Journal of Medicinal Chemistry 90, 1-9, 2015 | 37 | 2015 |
MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells V Di Giacomo, V Di Valerio, M Rapino, D Bosco, I Cacciatore, M Ciulla, ... Cellular and Molecular Biology 61 (3), 17-23, 2015 | 20 | 2015 |
Molecular mechanisms of learning and memory D Puzzo, J Fiorito, R Purgatorio, W Gulisano, A Palmeri, O Arancio, ... Genes, Environment and Alzheimer's Disease, 1-27, 2016 | 17 | 2016 |
Targeting the NO/cGMP/CREB phosphorylation signaling pathway in Alzheimer’s disease J Fiorito, SX Deng, DW Landry, O Arancio Neurochemical Basis of Brain Function and Dysfunction, 2018 | 7 | 2018 |
Strategy for overcoming Crebbp and EP300 mutations in lymphoma: Development of first-in-class HAT activators Y Liu, J Fiorito, Y Gonzalez, B Estrella, E Calcagno, E Zuccarello, ... Blood 134, 4068, 2019 | 5 | 2019 |
Effect of MRJF4 on C6 glioma cells proliferation and migration S Pacella, J Fiorito, I Cacciatore, V di Giacomo, A Patruno, M Rapino, ... Central Nervous System Agents in Medicinal Chemistry (Formerly Current …, 2017 | 5 | 2017 |
Histone acetyltransferase activators and compositions and uses thereof OA O'connor, JE Amengual, DW Landry, O Arancio, L Scotto, S Deng, ... US Patent 10,653,648, 2020 | 4 | 2020 |
Phosphodiesterase inhibitors and uses thereof DW Landry, S Deng, O Arancio, J Fiorito, A Wasmuth US Patent 10,626,113, 2020 | 3 | 2020 |
FIRST‐IN‐CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN‐HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY Y Liu, J Fiorito, Y Gonzale, E Zuccarello, E Calcagno, JM Camarillo, ... Hematological Oncology 37, 125-126, 2019 | 3 | 2019 |
Development of first-in-class histone acetyltransferase (HAT) activators for precision targeting of epigenetic derangements in lymphoma Y Liu, J Fiorito, Y Gonzalez, E Zuccarello, E Calcagno, A Mazzeo, ... Blood 132, 37, 2018 | 3 | 2018 |
Histone acetyltransferase activators and uses thereof O Arancio, S Deng, DW Landry, J Fiorito, R Purgatorio, JE Amengual, ... | 2 | 2017 |
Histone acetyltransferase (hat) regulators and uses thereof O Arancio, DW Landry, S Deng, JE Amengual, E Zuccarello, J Fiorito, ... US Patent App. 17/429,048, 2022 | 1 | 2022 |