| Cancer drug resistance: an evolving paradigm C Holohan, S Van Schaeybroeck, DB Longley, PG Johnston Nature Reviews Cancer 13 (10), 714-726, 2013 | 4650 | 2013 |
| Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis E Kerr, C Holohan, KM McLaughlin, J Majkut, S Dolan, K Redmond, ... Cell Death & Differentiation 19 (8), 1317-1327, 2012 | 109 | 2012 |
| Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly J Majkut, M Sgobba, C Holohan, N Crawford, AE Logan, E Kerr, ... Nature communications 5 (1), 3350, 2014 | 96 | 2014 |
| Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer JS Riley, R Hutchinson, DG McArt, N Crawford, C Holohan, I Paul, ... Cell death & disease 4 (12), e951-e951, 2013 | 78 | 2013 |
| Cytokine‐induced β‐cell apoptosis is NO‐dependent, mitochondria‐mediated and inhibited by BCL‐XL C Holohan, E Szegezdi, T Ritter, T O'Brien, A Samali Journal of cellular and molecular medicine 12 (2), 591-606, 2008 | 77 | 2008 |
| DED or alive: assembly and regulation of the death effector domain complexes JS Riley, A Malik, C Holohan, DB Longley Cell death & disease 6 (8), e1866-e1866, 2015 | 63 | 2015 |
| Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing TR Wilson, KM Redmond, KM McLaughlin, N Crawford, K Gately, ... Cell Death & Differentiation 16 (10), 1352-1361, 2009 | 56 | 2009 |
| Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent JL Hurwitz, I Stasik, EM Kerr, C Holohan, KM Redmond, KM McLaughlin, ... European Journal of Cancer 48 (7), 1096-1107, 2012 | 51 | 2012 |
| Prognostic and therapeutic relevance of c‐FLIP in acute myeloid leukaemia D McLornan, J Hay, K McLaughlin, C Holohan, AK Burnett, RK Hills, ... British journal of haematology 160 (2), 188-198, 2013 | 45 | 2013 |
| Characterization of a serine protease-mediated cell death program activated in human leukemia cells AR O'Connell, C Holohan, A Torriglia, BF Lee, C Stenson-Cox Experimental cell research 312 (1), 27-39, 2006 | 42 | 2006 |
| SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma N Crawford, I Stasik, C Holohan, J Majkut, M McGrath, PG Johnston, ... Cell death & disease 4 (7), e733-e733, 2013 | 33 | 2013 |
| FLIP: A targetable mediator of resistance to radiation in non–small cell lung cancer KA McLaughlin, Z Nemeth, CA Bradley, L Humphreys, I Stasik, C Fenning, ... Molecular cancer therapeutics 15 (10), 2432-2441, 2016 | 31 | 2016 |
| Cytokine-induced β-cell stress and death in type 1 diabetes mellitus L Vincenz, E Szegezdi, R Jäger, C Holohan, T O’Brien, A Samali Type 1 Diabetes-Complications, Pathogenesis, and Alternative Treatments, 2011 | 27 | 2011 |
| Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer J Ferris, M Espona-Fiedler, C Hamilton, C Holohan, N Crawford, ... Cell death discovery 6 (1), 61, 2020 | 22 | 2020 |
| The pseudo-caspase FLIP (L) regulates cell fate following p53 activation A Lees, AJ McIntyre, NT Crawford, F Falcone, C McCann, C Holohan, ... Proceedings of the National Academy of Sciences 117 (30), 17808-17819, 2020 | 21 | 2020 |
| The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) JZ Roberts, C Holohan, T Sessler, J Fox, N Crawford, JS Riley, ... Cell Death & Differentiation 27 (9), 2726-2741, 2020 | 19 | 2020 |
| Cytoplasmic FLIP (S) and nuclear FLIP (L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists C McCann, N Crawford, J Majkut, C Holohan, CWD Armstrong, ... Cell Death & Disease 9 (11), 1081, 2018 | 17 | 2018 |
| Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer PD Dunne, HG Coleman, P Bankhead, M Alderdice, RT Gray, S McQuaid, ... Oncotarget 9 (17), 13834, 2018 | 12 | 2018 |
| Regulation of FLIP(L) and TRAIL-R2 signalling by the SCFSkp2 Ubiquitin Ligase Complex JZ Roberts, C Holohan, T Sessler, J Fox, C Higgins, G Espona-Fiedler, ... bioRxiv, 723718, 2019 | 1 | 2019 |
| FLIP (L) determines colon cancer cell fate following p53 activation A Lees, AJMIJ McIntyre, NT Crawford, F Falcone, C McCann, GP Quinn, ... Cancer Research 80 (16_Supplement), 2409-2409, 2020 | | 2020 |
