Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer H Symolon, A Bushnev, Q Peng, H Ramaraju, SG Mays, JC Allegood, ... Molecular cancer therapeutics 10 (4), 648-657, 2011 | 65 | 2011 |
Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer EC Garnier-Amblard, SG Mays, RF Arrendale, MT Baillie, AS Bushnev, ... ACS Medicinal Chemistry Letters 2 (6), 438-443, 2011 | 40 | 2011 |
Development of the first low nanomolar liver receptor homolog-1 agonist through structure-guided design SG Mays, AR Flynn, JL Cornelison, CD Okafor, H Wang, G Wang, ... Journal of medicinal chemistry 62 (24), 11022-11034, 2019 | 26 | 2019 |
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists*♦ SG Mays, CD Okafor, RJ Whitby, D Goswami, J Stec, AR Flynn, ... Journal of Biological Chemistry 291 (49), 25281-25291, 2016 | 26 | 2016 |
Atomic-level mechanism of Pre-mRNA splicing in health and disease J Borisek, L Casalino, A Saltalamacchia, SG Mays, L Malcovati, ... Accounts of Chemical Research 54 (1), 144-154, 2020 | 24 | 2020 |
Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties EJ Miller, SG Mays, MT Baillie, RB Howard, DG Culver, M Saindane, ... ACS Medicinal Chemistry Letters 7 (5), 537-542, 2016 | 22 | 2016 |
Structure and dynamics of the liver receptor homolog 1–PGC1α complex SG Mays, CD Okafor, ML Tuntland, RJ Whitby, V Dharmarajan, J Stec, ... Molecular pharmacology 92 (1), 1-11, 2017 | 21 | 2017 |
Development of hybrid phospholipid mimics as effective agonists for liver receptor homologue-1 AR Flynn, SG Mays, EA Ortlund, NT Jui ACS Medicinal Chemistry Letters 9 (10), 1051-1056, 2018 | 20 | 2018 |
Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition JL Cornelison, ML Cato, AM Johnson, EH D'Agostino, D Melchers, ... Bioorganic & medicinal chemistry letters 30 (16), 127293, 2020 | 16 | 2020 |
Development of a versatile and sensitive direct ligand binding assay for human NR5A nuclear receptors EH D’Agostino, AR Flynn, JL Cornelison, SG Mays, A Patel, NT Jui, ... ACS Medicinal Chemistry Letters 11 (3), 365-370, 2019 | 12 | 2019 |
A phospholipid mimetic targeting LRH-1 ameliorates colitis SG Mays, EH D’Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, ... Cell Chemical Biology 29 (7), 1174-1186. e7, 2022 | 8 | 2022 |
Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist SG Mays, J Stec, X Liu, EH D’Agostino, RJ Whitby, EA Ortlund Scientific Reports 10 (1), 22279, 2020 | 5 | 2020 |
Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice SA Druzak, M Tardelli, SG Mays, M El Bejjani, X Mo, KM Maner-Smith, ... Nature Communications 14 (1), 2748, 2023 | 2 | 2023 |
A novel phospholipid mimetic targeting LRH-1 ameliorates colitis SG Mays, EH D’Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, ... | 2* | 2020 |
Modulators of liver receptor homologue 1 (LRH-1) and uses E Ortlund, S Mays, N Jui, A Flynn, M Dugan US Patent 10,843,996, 2020 | 1 | 2020 |
Role of Macroautophagy in Anti‐Cancer Effects of the Novel Sphingolipid, Enigmol S Mays, A Bushnev, M Baillie, H Yi, D Liotta, J Petros The FASEB Journal 29, 715.42, 2015 | 1 | 2015 |
330 FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS IN VIVOPROSTATE CANCER EFFICACY SG Mays, MT Baillie, EJ Miller, AS Bushnev, ST Pruett, DG Culver, ... The Journal of Urology 189 (4S), e133-e134, 2013 | 1 | 2013 |
The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits SG Mays, D Hercules, EA Ortlund, CD Okafor Protein Science 32 (10), e4754, 2023 | | 2023 |
Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses E Ortlund, S Mays, N Jui, A Flynn, M Dugan US Patent App. 18/200,431, 2023 | | 2023 |
Modulators of liver receptor homologue 1 (LRH-1) and uses E Ortlund, S Mays, N Jui, A Flynn, M Dugan US Patent 11,691,939, 2023 | | 2023 |