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Suzanne G. Mays
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Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer
H Symolon, A Bushnev, Q Peng, H Ramaraju, SG Mays, JC Allegood, ...
Molecular cancer therapeutics 10 (4), 648-657, 2011
652011
Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer
EC Garnier-Amblard, SG Mays, RF Arrendale, MT Baillie, AS Bushnev, ...
ACS Medicinal Chemistry Letters 2 (6), 438-443, 2011
402011
Development of the first low nanomolar liver receptor homolog-1 agonist through structure-guided design
SG Mays, AR Flynn, JL Cornelison, CD Okafor, H Wang, G Wang, ...
Journal of medicinal chemistry 62 (24), 11022-11034, 2019
262019
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists*♦
SG Mays, CD Okafor, RJ Whitby, D Goswami, J Stec, AR Flynn, ...
Journal of Biological Chemistry 291 (49), 25281-25291, 2016
262016
Atomic-level mechanism of Pre-mRNA splicing in health and disease
J Borisek, L Casalino, A Saltalamacchia, SG Mays, L Malcovati, ...
Accounts of Chemical Research 54 (1), 144-154, 2020
242020
Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties
EJ Miller, SG Mays, MT Baillie, RB Howard, DG Culver, M Saindane, ...
ACS Medicinal Chemistry Letters 7 (5), 537-542, 2016
222016
Structure and dynamics of the liver receptor homolog 1–PGC1α complex
SG Mays, CD Okafor, ML Tuntland, RJ Whitby, V Dharmarajan, J Stec, ...
Molecular pharmacology 92 (1), 1-11, 2017
212017
Development of hybrid phospholipid mimics as effective agonists for liver receptor homologue-1
AR Flynn, SG Mays, EA Ortlund, NT Jui
ACS Medicinal Chemistry Letters 9 (10), 1051-1056, 2018
202018
Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition
JL Cornelison, ML Cato, AM Johnson, EH D'Agostino, D Melchers, ...
Bioorganic & medicinal chemistry letters 30 (16), 127293, 2020
162020
Development of a versatile and sensitive direct ligand binding assay for human NR5A nuclear receptors
EH D’Agostino, AR Flynn, JL Cornelison, SG Mays, A Patel, NT Jui, ...
ACS Medicinal Chemistry Letters 11 (3), 365-370, 2019
122019
A phospholipid mimetic targeting LRH-1 ameliorates colitis
SG Mays, EH D’Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, ...
Cell Chemical Biology 29 (7), 1174-1186. e7, 2022
82022
Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
SG Mays, J Stec, X Liu, EH D’Agostino, RJ Whitby, EA Ortlund
Scientific Reports 10 (1), 22279, 2020
52020
Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice
SA Druzak, M Tardelli, SG Mays, M El Bejjani, X Mo, KM Maner-Smith, ...
Nature Communications 14 (1), 2748, 2023
22023
A novel phospholipid mimetic targeting LRH-1 ameliorates colitis
SG Mays, EH D’Agostino, AR Flynn, X Huang, G Wang, X Liu, EJ Millings, ...
2*2020
Modulators of liver receptor homologue 1 (LRH-1) and uses
E Ortlund, S Mays, N Jui, A Flynn, M Dugan
US Patent 10,843,996, 2020
12020
Role of Macroautophagy in Anti‐Cancer Effects of the Novel Sphingolipid, Enigmol
S Mays, A Bushnev, M Baillie, H Yi, D Liotta, J Petros
The FASEB Journal 29, 715.42, 2015
12015
330 FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS IN VIVOPROSTATE CANCER EFFICACY
SG Mays, MT Baillie, EJ Miller, AS Bushnev, ST Pruett, DG Culver, ...
The Journal of Urology 189 (4S), e133-e134, 2013
12013
The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits
SG Mays, D Hercules, EA Ortlund, CD Okafor
Protein Science 32 (10), e4754, 2023
2023
Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses
E Ortlund, S Mays, N Jui, A Flynn, M Dugan
US Patent App. 18/200,431, 2023
2023
Modulators of liver receptor homologue 1 (LRH-1) and uses
E Ortlund, S Mays, N Jui, A Flynn, M Dugan
US Patent 11,691,939, 2023
2023
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