Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules M Martinez-Bailen, AT Carmona, E Moreno-Clavijo, I Robina, D Ide, ... European Journal of Medicinal Chemistry 138, 532-542, 2017 | 27 | 2017 |
Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition M Martinez-Bailen, AT Carmona, AC Patterson-Orazem, RL Lieberman, ... Bioorganic chemistry 86, 652-664, 2019 | 20 | 2019 |
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry … M Martinez-Bailen, AT Carmona, F Cardona, C Matassini, A Goti, M Kubo, ... European Journal of Medicinal Chemistry 192, 112173, 2020 | 19 | 2020 |
Antimicrobial activity of phenolics isolated from the pruning wood residue of European plum (Prunus domestica L.) J Ortega-Vidal, A Cobo, E Ortega-Morente, A Gálvez, M Martínez-Bailén, ... Industrial Crops and Products 176, 114296, 2022 | 18 | 2022 |
Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning F Clemente, C Matassini, C Faggi, S Giachetti, C Cresti, A Morrone, ... Bioorganic Chemistry 98, 103740, 2020 | 17 | 2020 |
GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders M Martínez-Bailén, F Clemente, C Matassini, F Cardona Pharmaceuticals 15 (7), 823, 2022 | 16 | 2022 |
Multivalent glycosystems for human lectins M Martínez-Bailén, J Rojo, J Ramos-Soriano Chemical Society Reviews, 2023 | 15 | 2023 |
Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars M Martinez-Bailen, E Jimenez-Ortega, AT Carmona, I Robina, ... Bioorganic Chemistry 89, 103026, 2019 | 15 | 2019 |
Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase) F Clemente, C Matassini, S Giachetti, A Goti, A Morrone, ... The Journal of Organic Chemistry 86 (18), 12745-12761, 2021 | 13 | 2021 |
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono-and divalent pyrrolidine iminosugars V Pingitore, M Martínez-Bailén, AT Carmona, Z Mészáros, N Kulik, ... Bioorganic Chemistry 120, 105650, 2022 | 12 | 2022 |
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors J Franco, F Piacente, M Walter, S Fratta, M Ghanem, A Benzi, I Caffa, ... Pharmaceuticals 15 (7), 855, 2022 | 10 | 2022 |
Exploring Multi‐Subsite Binding Pockets in Proteins: DEEP‐STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B S Monaco, S Walpole, H Doukani, R Nepravishta, M Martínez‐Bailén, ... Chemistry–A European Journal 26 (44), 10024-10034, 2020 | 8 | 2020 |
Regioselectivity of the 1, 3-dipolar cycloaddition of organic azides to 7-heteronorbornadienes. Synthesis of β-substituted furans/pyrroles E Gil de Montes, M Martı́nez-Bailén, AT Carmona, I Robina, ... The Journal of Organic Chemistry 85 (14), 8923-8932, 2020 | 6 | 2020 |
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease M Velueta-Viveros, M Martínez-Bailén, A Puerta, LL Romero-Hernández, ... Bioorganic Chemistry, 105983, 2022 | 5 | 2022 |
Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors MG Davighi, F Clemente, C Matassini, A Morrone, A Goti, ... Molecules 25 (19), 4526, 2020 | 5 | 2020 |
Synthesis of a new β-galactosidase inhibitor displaying pharmacological chaperone properties for GM1 gangliosidosis F Clemente, M Martínez-Bailén, C Matassini, A Morrone, S Falliano, ... Molecules 27 (13), 4008, 2022 | 4 | 2022 |
Preparation of water-soluble glycopolymers derived from five-membered iminosugars M Martinez-Bailen, E Galbis, AT Carmona, MV de-Paz, I Robina European Polymer Journal 119, 213-221, 2019 | 4 | 2019 |
Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation M Martínez-Bailén, C Matassini, F Clemente, C Faggi, A Goti, F Cardona Organic Letters 25 (31), 5833-5837, 2023 | | 2023 |