| Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 D Martinez-Zapien, FX Ruiz, J Poirson, A Mitschler, J Ramirez, A Forster, ... Nature 529 (7587), 541-545, 2016 | 426 | 2016 |
| Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10 O Gallego, FX Ruiz, A Ardèvol, M Domínguez, R Alvarez, AR De Lera, ... Proceedings of the National Academy of Sciences 104 (52), 20764-20769, 2007 | 194 | 2007 |
| Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids O Gallego, OV Belyaeva, S Porté, FX Ruiz, AV Stetsenko, EV Shabrova, ... Biochemical Journal 399 (1), 101-109, 2006 | 138 | 2006 |
| Biological role of aldo–keto reductases in retinoic acid biosynthesis and signaling FX Ruiz, S Porté, X Parés, J Farrés Frontiers in pharmacology 3, 58, 2012 | 105 | 2012 |
| Modulation of aldose reductase inhibition by halogen bond tuning J Fanfrlík, M Kolář, M Kamlar, D Hurný, FX Ruiz, A Cousido-Siah, ... ACS chemical biology 8 (11), 2484-2492, 2013 | 92 | 2013 |
| Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of … MC Van Zandt, DL Whitehouse, A Golebiowski, MK Ji, M Zhang, ... Journal of Medicinal Chemistry 56 (6), 2568-2580, 2013 | 89 | 2013 |
| Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels FX Ruiz, O Gallego, A Ardèvol, A Moro, M Domínguez, S Alvarez, ... Chemico-biological interactions 178 (1-3), 171-177, 2009 | 85 | 2009 |
| Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily FX Ruiz, S Porté, O Gallego, A Moro, A Ardèvol, D Río-Espínola, C Rovira, ... Biochemical Journal 440 (3), 335-347, 2011 | 54 | 2011 |
| The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition ACS Chem J Fanfrlík, FX Ruiz, A Kadlčíková, J Řezáč, A Cousido-Siah, A Mitschler, ... Biol 10, 1637-1642, 2015 | 51* | 2015 |
| Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance FX Ruiz, E Arnold Current Opinion in Structural Biology 61 (Macromolecular Assemblies), 113-123, 2020 | 47 | 2020 |
| Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction A Golebiowski, D Whitehouse, RP Beckett, M Van Zandt, MK Ji, TR Ryder, ... Bioorganic & medicinal chemistry letters 23 (17), 4837-4841, 2013 | 45 | 2013 |
| Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity F Llorens, N Roher, FA Miró, S Sarno, FX Ruiz, F Meggio, M Plana, ... Biochemical Journal 375 (3), 623-631, 2003 | 44 | 2003 |
| Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first six months of the COVID-19 pandemic JH Lubin, C Zardecki, EM Dolan, C Lu, Z Shen, S Dutta, JD Westbrook, ... bioRxiv, 2020 | 43 | 2020 |
| 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors A Golebiowski, RP Beckett, M Van Zandt, MK Ji, D Whitehouse, TR Ryder, ... Bioorganic & medicinal chemistry letters 23 (7), 2027-2030, 2013 | 39 | 2013 |
| Human and rodent aldo–keto reductases from the AKR1B subfamily and their specificity with retinaldehyde FX Ruiz, A Moro, O Gallego, A Ardèvol, C Rovira, JM Petrash, X Parés, ... Chemico-biological interactions 191 (1-3), 199-205, 2011 | 39 | 2011 |
| X-ray crystal structure of the full length human chitotriosidase (CHIT1) reveals features of its chitin binding domain F Fadel, Y Zhao, A Cousido-Siah, FX Ruiz, A Mitschler, A Podjarny PloS one 11 (4), e0154190, 2016 | 38 | 2016 |
| 2, 4, 5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies D Kang, FX Ruiz, Y Sun, D Feng, L Jing, Z Wang, T Zhang, S Gao, L Sun, ... Journal of Medicinal Chemistry, 2021 | 37 | 2021 |
| Aldo–keto reductases in retinoid metabolism: search for substrate specificity and inhibitor selectivity S Porté, FX Ruiz, J Giménez, I Molist, S Alvarez, M Domínguez, R Alvarez, ... Chemico-biological interactions 202 (1-3), 186-194, 2013 | 37 | 2013 |
| Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG … D Kang, FX Ruiz, D Feng, A Pilch, T Zhao, F Wei, Z Wang, Y Sun, Z Fang, ... Journal of medicinal chemistry 63 (3), 1298-1312, 2020 | 32 | 2020 |
| New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM F Fadel, Y Zhao, R Cachau, A Cousido-Siah, FX Ruiz, K Harlos, ... Acta Crystallographica Section D: Biological Crystallography 71 (7), 1455-1470, 2015 | 30 | 2015 |
