| Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir PK Quashie, T Mesplède, YS Han, M Oliveira, DN Singhroy, T Fujiwara, ... Journal of virology 86 (5), 2696-2705, 2012 | 260 | 2012 |
| HIV drug resistance against strand transfer integrase inhibitors K Anstett, B Brenner, T Mesplede, MA Wainberg Retrovirology 14, 1-16, 2017 | 212 | 2017 |
| The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation P Nakhaei, T Mesplede, M Solis, Q Sun, T Zhao, L Yang, TH Chuang, ... PLoS pathogens 5 (11), e1000650, 2009 | 201 | 2009 |
| Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure T Mesplède, PK Quashie, N Osman, Y Han, DN Singhroy, Y Lie, ... Retrovirology 10, 1-7, 2013 | 150 | 2013 |
| Evolution of HIV integrase resistance mutations PK Quashie, T Mesplède, MA Wainberg Current opinion in infectious diseases 26 (1), 43-49, 2013 | 112 | 2013 |
| p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes T Mesplède, D Gagnon, F Bergeron-Labrecque, I Azar, H Sénéchal, ... Journal of virology 86 (1), 94-107, 2012 | 107 | 2012 |
| Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir M Oliveira, RI Ibanescu, K Anstett, T Mésplède, JP Routy, MA Robbins, ... Retrovirology 15, 1-14, 2018 | 98 | 2018 |
| The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness M Wares, T Mesplède, PK Quashie, N Osman, Y Han, MA Wainberg Retrovirology 11, 1-8, 2014 | 90 | 2014 |
| Transcriptional re‐programming of primary macrophages reveals distinct apoptotic and anti‐tumoral functions of IRF‐3 and IRF‐7 D Goubau, R Romieu‐Mourez, M Solis, E Hernandez, T Mesplède, R Lin, ... European journal of immunology 39 (2), 527-540, 2009 | 86 | 2009 |
| Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase PK Quashie, M Oliviera, T Veres, N Osman, YS Han, S Hassounah, Y Lie, ... Journal of virology 89 (6), 3163-3175, 2015 | 82 | 2015 |
| HIV-1 resistance dynamics in patients with virologic failure to dolutegravir maintenance monotherapy IEA Wijting, C Lungu, BJA Rijnders, ME van der Ende, HT Pham, ... The Journal of infectious diseases 218 (5), 688-697, 2018 | 80 | 2018 |
| The development of novel HIV integrase inhibitors and the problem of drug resistance MA Wainberg, T Mesplède, PK Quashie Current opinion in virology 2 (5), 656-662, 2012 | 76 | 2012 |
| Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors BG Brenner, R Thomas, JL Blanco, RI Ibanescu, M Oliveira, T Mesplède, ... Journal of Antimicrobial Chemotherapy 71 (7), 1948-1953, 2016 | 71 | 2016 |
| Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis RD Sloan, BD Kuhl, T Mesplède, J Münch, DA Donahue, MA Wainberg Journal of virology 87 (14), 8110-8123, 2013 | 71 | 2013 |
| Resistance to HIV integrase inhibitors T Mesplède, PK Quashie, MA Wainberg Current opinion in HIV and AIDS 7 (5), 401-408, 2012 | 71 | 2012 |
| Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase PK Quashie, T Mesplède, YS Han, T Veres, N Osman, S Hassounah, ... Antimicrobial agents and chemotherapy 57 (12), 6223-6235, 2013 | 69 | 2013 |
| Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors M Oliveira, T Mesplede, PK Quashie, D Moïsi, MA Wainberg Aids 28 (6), 813-819, 2014 | 68 | 2014 |
| Resistance against integrase strand transfer inhibitors and relevance to HIV persistence T Mesplède, MA Wainberg Viruses 7 (7), 3703-3718, 2015 | 66 | 2015 |
| Involvement of TBK1 and IKKϵ in lipopolysaccharide‐induced activation of the interferon response in primary human macrophages M Solis, R Romieu‐Mourez, D Goubau, N Grandvaux, T Mesplede, ... European journal of immunology 37 (2), 528-539, 2007 | 65 | 2007 |
| Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity DN Singhroy, T Mesplède, A Sabbah, PK Quashie, JP Falgueyret, ... Retrovirology 10, 1-10, 2013 | 63 | 2013 |
Bluma BrennerAssistant professor McGill UniversityVerified email at mcgill.ca
