Bon-Kyoung Koo

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Young-yun KongProfessor of biological sciences, Seoul National UniversityVerified email at snu.ac.kr
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Ki-Jun YoonKorea Advanced Institute of Science and Technology (KAIST)Verified email at kaist.ac.kr
Benjamin D SimonsUniversity of CambridgeVerified email at cam.ac.uk
Shabaz MohammedAssociate Professor of Proteomics, University of OxfordVerified email at bioch.ox.ac.uk
Albert J. R. HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center and Utrecht UniversityVerified email at uu.nl
Hyun-Woo JeongMax-Planck Institute for Molecular BiomedicineVerified email at mpi-muenster.mpg.de
Edwin CuppenHoogleraar Humane GeneticaVerified email at umcutrecht.nl
Madelon MauriceProfessor of Molecular Cell Biology, Center for Molecular Medicine, UMC UtrechtVerified email at umcutrecht.nl
Mustata RCScientist, Stemcell Technologies UKVerified email at stemcell.com
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Prof Nick BarkerA-STAR Institute of Molecular and Cellular Biology, SingaporeVerified email at imcb.a-star.edu.sg
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Gerald SchwankUniversity ZurichVerified email at pharma.uzh.ch
Inha HeoHubrecht InstituteVerified email at hubrecht.eu
Shalev ItzkovitzProfessor, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Javier MuñozBiobizkaia Health Research InstituteVerified email at bio-bizkaia.eus
turan demircanMugla Sitki Kocman University, Tıp FakültesiVerified email at mu.edu.tr
Onur BasakGroup leader at the Translational Neuroscience, BCRM, UMCU, Utrecht, theVerified email at umcutrecht.nl

Bon-Kyoung Koo

Center for Genome Engineering (CGE), Institute for Basic Science (IBS)

Verified email at ibs.re.kr

Intestine Stem cell Wnt Organoids CRISPR/Cas


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Human organoids: model systems for human biology and medicine J Kim, BK Koo, JA Knoblich Nature Reviews Molecular Cell Biology 21 (10), 571-584, 2020	1674	2020
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013	1658	2013
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1444	2011
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarró, ... Nature medicine 23 (12), 1424-1435, 2017	1277	2017
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012	1020	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012	849	2012
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature protocols 11 (9), 1724-1743, 2016	732	2016
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium MY Turco, L Gardner, J Hughes, T Cindrova-Davies, MJ Gomez, L Farrell, ... Nature cell biology 19 (5), 568-577, 2017	589	2017
Modeling mouse and human development using organoid cultures M Huch, BK Koo Development 142 (18), 3113-3125, 2015	566	2015
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ... Cell 155 (2), 357-368, 2013	547	2013
Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration J Choi, JE Park, G Tsagkogeorga, M Yanagita, BK Koo, N Han, JH Lee Cell stem cell 27 (3), 366-382. e7, 2020	404	2020
Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012	372	2012
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ... Molecular and cellular biology, 2012	313	2012
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ... Cell stem cell 16 (2), 158-170, 2015	297	2015
Human gastric cancer modelling using organoids T Seidlitz, SR Merker, A Rothe, F Zakrzewski, C von Neubeck, ... Gut 68 (2), 207-217, 2019	293	2019
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch BK Koo, HS Lim, R Song, MJ Yoon, KJ Yoon, JS Moon, YW Kim, M Kwon, ... Oxford University Press for The Company of Biologists Limited 132 (15), 3459 …, 2005	291	2005
Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis K Nanki, K Toshimitsu, A Takano, M Fujii, M Shimokawa, Y Ohta, ... Cell 174 (4), 856-869. e17, 2018	280	2018
DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate … KJ Howell, J Kraiczy, KM Nayak, M Gasparetto, A Ross, C Lee, TN Mak, ... Gastroenterology 154 (3), 585-598, 2018	280	2018
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response J Heijmans, JFL de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, ... Cell reports 3 (4), 1128-1139, 2013	276	2013
A crucial role of WW45 in developing epithelial tissues in the mouse JH Lee, TS Kim, TH Yang, BK Koo, SP Oh, KP Lee, HJ Oh, SH Lee, ... The EMBO journal 27 (8), 1231-1242, 2008	231	2008

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