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Pierce Ogden
Pierce Ogden
CSO, Manifold Bio
Verified email at manifold.bio
Title
Cited by
Cited by
Year
Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
PJ Ogden, ED Kelsic, S Sinai, GM Church
Science 366 (6469), 1139-1143, 2019
2832019
Deep diversification of an AAV capsid protein by machine learning
DH Bryant, A Bashir, S Sinai, NK Jain, PJ Ogden, PF Riley, GM Church, ...
Nature Biotechnology 39 (6), 691-696, 2021
2132021
Toward machine-guided design of proteins
S Biswas, G Kuznetsov, PJ Ogden, NJ Conway, RP Adams, GM Church
BioRxiv, 337154, 2018
372018
A liquid chromatography/mass spectrometry method for screening disulfide tethering fragments
KK Hallenbeck, JL Davies, C Merron, P Ogden, E Sijbesma, C Ottmann, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 23 (2), 183-192, 2018
232018
Deep Search: Next-Gen Strategies for Accelerating AAV Capsid Engineering
E Kelsic, S Sinai, P Ogden, M Nowak, G Church
MOLECULAR THERAPY 26 (5), 168-168, 2018
22018
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production
NK Jain, PJ Ogden, GM Church
Elife 12, RP87730, 2024
12024
Systematic Functional Characterization of the AAV Capsid Fitness Landscape
E Kelsic, P Ogden, G Church
MOLECULAR THERAPY 26 (5), 29-29, 2018
12018
Inverting the Drug Discovery Funnel: In Vivo First Screening for mAb Blood-brain Barrier Penetration Yields Molecules with Novel Uptake Properties (P8-4.007)
P Ogden, A Garcia, S Alioto, M Nichols, K Nudel, S Carroll, J Avera, ...
Neurology 102 (17_supplement_1), 6315, 2024
2024
Methods and compositions for protein detection
P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang
US Patent App. 18/452,894, 2024
2024
Methods and compositions for protein detection
P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang
US Patent App. 17/718,275, 2023
2023
Methods and compositions for protein detection
P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang
US Patent App. 17/518,221, 2023
2023
Viral capsid polypeptides
E Kelsic, S Sinai, P Ogden, GM Church
US Patent App. 17/774,306, 2023
2023
Viral vectors exhibiting improved gene delivery properties
GM Church, E Kelsic, P Ogden, S Sinai
US Patent App. 17/055,318, 2021
2021
Massively Parallel Deep Diversification of AAV Capsid Proteins by Machine Learning
D Bryant, A Bashir, S Sinai, N Jain, P Ogden, P Riley, GM Church, ...
MOLECULAR THERAPY 28 (4), 240-240, 2020
2020
Machine-Guided Design of AAV Capsid Proteins with Experimentally Augmented Evolutionary Data
S Sinai, E Kelsic, J Tan, N Jain, P Ogden, M Nowak, GM Church
MOLECULAR THERAPY 27 (4), 52-52, 2019
2019
Discovery of a Novel Frameshifted ORF within the AAV Capsid Gene
E Kelsic, P Ogden, G Church
MOLECULAR THERAPY 27 (4), 314-314, 2019
2019
Computational Design of AAV Capsids Using Machine Learning Models Trained on Deep Mutational Libraries
D Bryant, S Sinai, P Ogden, N Jain, A Bashir, L Colwell, E Kelsic, ...
MOLECULAR THERAPY 27 (4), 96-96, 2019
2019
Dissecting Protein Fitness Landscapes Using DNA Synthesis and Sequencing: Case Studies in AAV and Beyond
P Ogden
Harvard University, 2019
2019
COVALENT STRATEGIES AND METHODS FOR TARGETING NON-CATALYTIC CYSTIENE RESIDUES
DM TURNER, JL DAVIES, C MERRON, P OGDEN, E SIJBESMA, ...
INFORMATION TO ALL USERS The quality of this reproduction is dependent upon …, 2018
2018
A LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHOD FOR SCREENING DISULFIDE TETHERING FRAGMENTS
JL DAVIES, C MERRON, P OGDEN, E SIJBESMA, C OTTMANN, ...
INFORMATION TO ALL USERS The quality of this reproduction is dependent upon …, 2018
2018
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