| Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein L He, A Sabet, S Djedjos, R Miller, X Sun, MA Hussain, S Radovick, ... Cell 137 (4), 635-646, 2009 | 602 | 2009 |
| Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation J Wang, D Gallagher, LM DeVito, GI Cancino, D Tsui, L He, GM Keller, ... Cell stem cell 11 (1), 23-35, 2012 | 499 | 2012 |
| Metformin action: concentrations matter L He, FE Wondisford Cell metabolism 21 (2), 159-162, 2015 | 458 | 2015 |
| Metformin improves mitochondrial respiratory activity through activation of AMPK Y Wang, H An, T Liu, C Qin, H Sesaki, S Guo, S Radovick, M Hussain, ... Cell reports 29 (6), 1511-1523. e5, 2019 | 283 | 2019 |
| Current understanding of metformin effect on the control of hyperglycemia in diabetes H An, L He The Journal of endocrinology 228 (3), R97, 2016 | 231 | 2016 |
| CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain J Wang, ICG Weaver, A Gauthier-Fisher, H Wang, L He, J Yeomans, ... Developmental cell 18 (1), 114-125, 2010 | 222 | 2010 |
| Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK)*♦ J Cao, S Meng, E Chang, K Beckwith-Fickas, L Xiong, RN Cole, ... Journal of Biological Chemistry 289 (30), 20435-20446, 2014 | 198 | 2014 |
| Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex S Meng, J Cao, Q He, L Xiong, E Chang, S Radovick, FE Wondisford, ... Journal of Biological Chemistry 290 (6), 3793-3802, 2015 | 174 | 2015 |
| Metformin and systemic metabolism L He Trends in Pharmacological Sciences 41 (11), 868-881, 2020 | 143 | 2020 |
| Metformin acts on two different molecular pathways to enhance adult neural precursor proliferation/self-renewal and differentiation M Fatt, K Hsu, L He, F Wondisford, FD Miller, DR Kaplan, J Wang Stem cell reports 5 (6), 988-995, 2015 | 132 | 2015 |
| Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane: role of TRB3 in inhibition of Akt/protein kinase B activation L He, FA Simmen, HM Mehendale, MJJ Ronis, TM Badger Journal of Biological Chemistry 281 (16), 11126-11134, 2006 | 127 | 2006 |
| Inhibition of the Interferon-γ/Signal Transducers and Activators of Transcription (STAT) Pathway by Hypermethylation at a STAT-binding Site in the p21 WAF1 Promoter Region B Chen, L He, VH Savell, JJ Jenkins, DM Parham Cancer research 60 (12), 3290-3298, 2000 | 120 | 2000 |
| Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats JC Rowlands, L He, R Hakkak, MJJ Ronis, TM Badger The Journal of nutrition 131 (12), 3281-3287, 2001 | 110 | 2001 |
| Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms N Fang, Q Li, S Yu, J Zhang, L He, MJJ Ronis, TM Badger Journal of Alternative & Complementary Medicine 12 (2), 125-132, 2006 | 108 | 2006 |
| Novel mechanism of Foxo1 phosphorylation in glucagon signaling in control of glucose homeostasis Y Wu, Q Pan, H Yan, K Zhang, X Guo, Z Xu, W Yang, Y Qi, CA Guo, ... Diabetes 67 (11), 2167-2182, 2018 | 85 | 2018 |
| A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions K MohanKumar, K Namachivayam, T Song, B Jake Cha, A Slate, ... Nature communications 10 (1), 3494, 2019 | 81 | 2019 |
| Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions CJ Romero, E Pine-Twaddell, DI Sima, RS Miller, L He, F Wondisford, ... Molecular and cellular biology 32 (21), 4258-4269, 2012 | 67 | 2012 |
| Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity J Cao, J Peng, H An, Q He, T Boronina, S Guo, MF White, PA Cole, L He Nature Communications 8 (1), 131, 2017 | 63 | 2017 |
| Control of Foxo1 gene expression by co-activator P300 AR Wondisford, L Xiong, E Chang, S Meng, DJ Meyers, M Li, PA Cole, ... Journal of Biological Chemistry 289 (7), 4326-4333, 2014 | 54 | 2014 |
| Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health L He, JC Marecki, G Serrero, FA Simmen, MJJ Ronis, TM Badger Molecular endocrinology 21 (10), 2541-2550, 2007 | 54 | 2007 |
