| Mitochondrial and metabolic dysfunction in ageing and age-related diseases JA Amorim, G Coppotelli, AP Rolo, CM Palmeira, JM Ross, DA Sinclair Nature Reviews Endocrinology 18 (4), 243-258, 2022 | 299 | 2022 |
| Loss of epigenetic information as a cause of mammalian aging JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 186 (2), 305-326. e27, 2023 | 249 | 2023 |
| Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins CM Palmeira, JS Teodoro, JA Amorim, C Steegborn, DA Sinclair, AP Rolo Free radical biology and medicine 141, 483-491, 2019 | 143 | 2019 |
| DNA break-induced epigenetic drift as a cause of mammalian aging M Hayano, JH Yang, MS Bonkowski, JA Amorim, JM Ross, G Coppotelli, ... BioRxiv, 808659, 2019 | 41 | 2019 |
| Regulation of mitochondrial function and its impact in metabolic stress F V Duarte, J A Amorim, C M Palmeira, A P Rolo Current medicinal chemistry 22 (20), 2468-2479, 2015 | 37 | 2015 |
| Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment X Chen, JA Amorim, GA Moustafa, JJ Lee, Z Yu, K Ishihara, Y Iesato, ... Aging (Albany NY) 12 (24), 24504, 2020 | 34 | 2020 |
| Mitochondria in excitatory and inhibitory synapses have similar susceptibility to amyloid-β peptides modeling Alzheimer’s disease JA Amorim, PM Canas, AR Tomé, AP Rolo, P Agostinho, CM Palmeira, ... Journal of Alzheimer's Disease 60 (2), 525-536, 2017 | 19 | 2017 |
| Potent and specific activators for mitochondrial sirtuins Sirt3 and Sirt5 B Suenkel, S Valente, C Zwergel, S Weiss, E Di Bello, R Fioravanti, ... Journal of medicinal chemistry 65 (20), 14015-14031, 2022 | 18 | 2022 |
| Molecular and cellular characterization of SIRT1 allosteric activators MB Schultz, C Rinaldi, Y Lu, JA Amorim, DA Sinclair Protein Acetylation: Methods and Protocols, 133-149, 2019 | 17 | 2019 |
| Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver FV Duarte, JA Amorim, AT Varela, JS Teodoro, AP Gomes, RA Cunha, ... Purinergic Signalling 13 (2), 179-190, 2017 | 10 | 2017 |
| Chenodeoxycholic acid has non-thermogenic, mitodynamic anti-obesity effects in an in vitro CRISPR/Cas9 model of bile acid receptor TGR5 knockdown JS Teodoro, IF Machado, AC Castela, JA Amorim, I Jarak, RA Carvalho, ... International Journal of Molecular Sciences 22 (21), 11738, 2021 | 8 | 2021 |
| Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes JA Amorim, DA Sinclair Mitochondrial Regulation: Methods and Protocols, 301-309, 2021 | 4 | 2021 |
| The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function JS Teodoro, JA Amorim, IF Machado, AC Castela, C Steegborn, ... International Journal of Molecular Sciences 21 (14), 4896, 2020 | 4 | 2020 |
| TIME-seq enables scalable and inexpensive epigenetic age predictions PT Griffin, AE Kane, A Trapp, J Li, M Arnold, JR Poganik, MS McNamara, ... bioRxiv, 2021.10. 25.465725, 2021 | 2 | 2021 |
| Disrupting the Epigenome in Novel Nice Mice to Study Age-Related Cognitive Decline JM Ross, G Coppotelli, J Amorim, E Hillstedt, E Potts, D Sinclair Innovation in Aging 2 (suppl_1), 626-626, 2018 | 1 | 2018 |
| Erratum: Loss of epigenetic information as a cause of mammalian aging (Cell (2023) 186 (2)(305–326. e27),(S0092867422015707),(10.1016/j. cell. 2022.12. 027)) JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 187 (5), 1312-1313, 2024 | | 2024 |
| Loss of epigenetic information as a cause of mammalian aging JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ... Cell 187 (5), 1312-1313, 2024 | | 2024 |
| TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction PT Griffin, AE Kane, A Trapp, J Li, M Arnold, JR Poganik, RJ Conway, ... Nature Aging, 1-14, 2024 | | 2024 |
| Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria JA Amorim, JS Teodoro, CM Palmeira Anti-obesity Drug Discovery and Development 4, 57, 2018 | | 2018 |
| A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION J Amorim, S Tackur, M Bonkowski, A Rolo, C Palmeira, D Sinclair Innovation in Aging 2 (Suppl 1), 878, 2018 | | 2018 |
David A. SinclairHarvard Medical School (Genetics)Verified email at hms.harvard.edu
