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Milad Ghomlaghi
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Year
An extended mathematical model of tumor growth and its interaction with the immune system, to be used for developing an optimized immunotherapy treatment protocol
M Qomlaqi, F Bahrami, M Ajami, J Hajati
Mathematical biosciences 292, 1-9, 2017
502017
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
AL Kearney#, DM Norris#, M Ghomlaghi#, MKL Wong, SJ Humphrey, ...
Elife 10, e66942, 2021
302021
Feedback, crosstalk and competition: ingredients for emergent non-linear behaviour in the PI3K/mTOR signalling network
M Ghomlaghi, A Hart, N Hoang, S Shin, LK Nguyen
International journal of molecular sciences 22 (13), 6944, 2021
212021
Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1
M Ghomlaghi, G Yang, SY Shin, DE James, LK Nguyen
PLoS computational biology 17 (9), e1008513, 2021
172021
Integrative modelling of signalling network dynamics identifies cell type-selective therapeutic strategies for FGFR4-driven cancers
SY Shin, NJ Chew, M Ghomlaghi, AC Chüeh, Y Jeong, LK Nguyen, ...
bioRxiv, 2021.11. 03.467180, 2023
22023
Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1
M Ghomlaghi, S Shin, G Yang, LK James, David E,Nguyen
bioRxiv, 2020
12020
Development and validation of ‘Patient Optimizer’(POP) algorithms for predicting surgical risk with machine learning
G Kowadlo, Y Mittelberg, M Ghomlaghi, DK Stiglitz, K Kishore, R Guha, ...
BMC Medical Informatics and Decision Making 24 (1), 1-17, 2024
2024
Integrative modeling and analysis of signaling crosstalk reveal molecular switches coordinating Yes-associated protein transcriptional activities
M Ghomlaghi, M Theocharous, N Hoang, SY Shin, A von Kriegsheim, ...
Iscience 27 (3), 2024
2024
Stress pathway outputs are encoded by pH-dependent phase separation of its components.
Y Didan, M Ghomlaghi, LK Nguyen, DCH Ng
bioRxiv, 2024.02. 24.581896, 2024
2024
Systems modelling of TGF-β/Hippo signalling crosstalk uncovers molecular switches that coordinate YAP transcriptional complexes (submitted to iScience)
M Ghomlaghi, M Theocharous, SY Shin, E O’Neill, LK Nguyen
bioRxiv, 2022.04. 06.487403, 2022
2022
Systems modelling and characterization of TGFβ-Hippo signalling crosstalk reveals ITCH promotes breast tumorigenesis through modulation of opposing YAP protein complexes
LN Milad Ghomlaghi , Mandy Theocharous , Sungyoung Shin
33rd Lorne Cancer Conference 2021, 2021
2021
Akt regulates PIP3 production by PI3K to form a potent negative feedback loop
JGB Dougall M. Norris1#, Alison L. Kearney1#, Milad Ghomlaghi2#, Sungyoung ...
The Society of Mathematical Biology, https://smb2020.org/Milad-Ghomlaghi/, 2020
2020
Computational Analysis Predicts the GBL Switch Within the PI3K/mTOR Signalling Network Drives Dose-Dependent Biphasic Behaviour of Akt and S6k1
M Ghomlaghi, S Shin, LK Nguyen
Cell Signalling and its Therapeutic Implications, 2019
2019
Integrative Network Modelling to Advance Systems-level Understanding of Signalling Networks and Identify New Cancer Therapies
M GHOMLAGHI
Monash University, 0
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Articles 1–14