| PTP1B as a drug target: recent developments in PTP1B inhibitor discovery S Zhang, ZY Zhang Drug discovery today 12 (9-10), 373-381, 2007 | 708 | 2007 |
| Structural and functional analysis of the costimulatory receptor programmed death-1 X Zhang, JCD Schwartz, X Guo, S Bhatia, E Cao, L Chen, ZY Zhang, ... Immunity 20 (3), 337-347, 2004 | 589 | 2004 |
| Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development ZY Zhang Annual review of pharmacology and toxicology 42 (1), 209-234, 2002 | 580 | 2002 |
| Regulation of PTP1B via glutathionylation of the active site cysteine 215 WC Barrett, JP DeGnore, S König, HM Fales, YF Keng, ZY Zhang, MB Yim, ... Biochemistry 38 (20), 6699-6705, 1999 | 577 | 1999 |
| Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate JA Stuckey, HL Schubert, EB Fauman, ZY Zhang, JE Dixon, MA Saper Nature 370 (6490), 571-575, 1994 | 519 | 1994 |
| Protein tyrosine phosphatases: prospects for therapeutics ZY Zhang Current opinion in chemical biology 5 (4), 416-423, 2001 | 516 | 2001 |
| Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design YA Puius, Y Zhao, M Sullivan, DS Lawrence, SC Almo, ZY Zhang Proceedings of the National Academy of Sciences 94 (25), 13420-13425, 1997 | 512 | 1997 |
| Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B WC Barrett, JP DeGnore, YF Keng, ZY Zhang, MB Yim, PB Chock Journal of Biological Chemistry 274 (49), 34543-34546, 1999 | 421 | 1999 |
| Leptin and insulin act on POMC neurons to promote the browning of white fat GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede, E Balland, TL Merry, ... Cell 160 (1), 88-104, 2015 | 399 | 2015 |
| Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis ZY Zhang Critical reviews in biochemistry and molecular biology 33 (1), 1-52, 1998 | 380 | 1998 |
| Dissecting the catalytic mechanism of protein-tyrosine phosphatases. ZY Zhang, Y Wang, JE Dixon Proceedings of the National Academy of Sciences 91 (5), 1624-1627, 1994 | 369 | 1994 |
| Protein tyrosine phosphatases as potential therapeutic targets R He, Z Yu, R Zhang, Z Zhang Acta pharmacologica sinica 35 (10), 1227-1246, 2014 | 350 | 2014 |
| Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402 ZY Zhang, JE Dixon Biochemistry 32 (36), 9340-9345, 1993 | 339 | 1993 |
| Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+ CD25+ regulatory T-cells of type 1 diabetic subjects SA Long, K Cerosaletti, PL Bollyky, M Tatum, H Shilling, S Zhang, ... diabetes 59 (2), 407-415, 2010 | 332 | 2010 |
| PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity ZY Zhang, SY Lee Expert opinion on investigational drugs 12 (2), 223-233, 2003 | 325 | 2003 |
| Substrate specificity of the protein tyrosine phosphatases. ZY Zhang, AM Thieme-Sefler, D Maclean, DJ McNamara, EM Dobrusin, ... Proceedings of the National Academy of Sciences 90 (10), 4446-4450, 1993 | 315 | 1993 |
| Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure K Shen, YF Keng, L Wu, XL Guo, DS Lawrence, ZY Zhang Journal of Biological Chemistry 276 (50), 47311-47319, 2001 | 286 | 2001 |
| Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase. ZY Zhang, JC Clemens, HL Schubert, JA Stuckey, MW Fischer, DM Hume, ... Journal of Biological Chemistry 267 (33), 23759-23766, 1992 | 282 | 1992 |
| The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases B Zhou, ZX Wang, YU Zhao, DL Brautigan, ZY Zhang Journal of Biological Chemistry 277 (35), 31818-31825, 2002 | 264 | 2002 |
| Protein–tyrosine phosphatases: structure, mechanism, and inhibitor discovery TR Burke Jr, ZY Zhang Peptide Science 47 (3), 225-241, 1998 | 248 | 1998 |
Zhihong YuVanderbilt University Medical CenterVerified email at vumc.org
