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Lixin Wan
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SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
H Inuzuka, S Shaik, I Onoyama, D Gao, A Tseng, RS Maser, B Zhai, ...
Nature 471 (7336), 104-109, 2011
6882011
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
P Liu, M Begley, W Michowski, H Inuzuka, M Ginzberg, D Gao, P Tsou, ...
Nature 508 (7497), 541-545, 2014
3762014
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function
A Papa, L Wan, M Bonora, L Salmena, MS Song, RM Hobbs, A Lunardi, ...
Cell 157 (3), 595-610, 2014
3062014
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
P Liu, W Gan, H Inuzuka, AS Lazorchak, D Gao, O Arojo, D Liu, L Wan, ...
Nature cell biology 15 (11), 1340-1350, 2013
2982013
mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR
D Gao, H Inuzuka, MKM Tan, H Fukushima, JW Locasale, P Liu, L Wan, ...
Molecular cell 44 (2), 290-303, 2011
2652011
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ...
Science 364 (6441), eaau0159, 2019
2292019
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase
H Inuzuka, A Tseng, D Gao, B Zhai, Q Zhang, S Shaik, L Wan, XL Ang, ...
Cancer cell 18 (2), 147-159, 2010
2282010
Targeting Cdc20 as a novel cancer therapeutic strategy
L Wang, J Zhang, L Wan, X Zhou, Z Wang, W Wei
Pharmacology & therapeutics 151, 141-151, 2015
2172015
Acetylation-dependent regulation of Skp2 function
H Inuzuka, D Gao, LWS Finley, W Yang, L Wan, H Fukushima, YR Chin, ...
Cell 150 (1), 179-193, 2012
2132012
Tumor suppressor functions of FBW7 in cancer development and progression
Z Wang, H Inuzuka, J Zhong, L Wan, H Fukushima, FH Sarkar, W Wei
FEBS letters 586 (10), 1409-1418, 2012
1812012
Phosphorylation of EZH2 by AMPK suppresses PRC2 methyltransferase activity and oncogenic function
L Wan, K Xu, Y Wei, J Zhang, T Han, C Fry, Z Zhang, YV Wang, L Huang, ...
Molecular cell 69 (2), 279-291. e5, 2018
1622018
MC1R is a potent regulator of PTEN after UV exposure in melanocytes
J Cao, L Wan, E Hacker, X Dai, S Lenna, C Jimenez-Cervantes, Y Wang, ...
Molecular cell 51 (4), 409-422, 2013
1612013
APCCdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction
L Wan, M Tan, J Yang, H Inuzuka, X Dai, T Wu, J Liu, S Shaik, G Chen, ...
Developmental cell 29 (4), 377-391, 2014
1382014
Skp2: a novel potential therapeutic target for prostate cancer
Z Wang, D Gao, H Fukushima, H Inuzuka, P Liu, L Wan, FH Sarkar, W Wei
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1825 (1), 11-17, 2012
1382012
RAF-MEK-ERK pathway in cancer evolution and treatment
R Ullah, Q Yin, AH Snell, L Wan
Seminars in cancer biology 85, 123-154, 2022
1352022
Cdc20: a potential novel therapeutic target for cancer treatment
Z Wang, L Wan, J Zhong, H Inuzuka, P Liu, FH Sarkar, W Wei
Current pharmaceutical design 19 (18), 3210-3214, 2013
1262013
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction
D Gao, L Wan, H Inuzuka, AH Berg, A Tseng, B Zhai, S Shaik, E Bennett, ...
Molecular cell 39 (5), 797-808, 2010
1122010
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1
L Wan, W Zou, D Gao, H Inuzuka, H Fukushima, AH Berg, R Drapp, ...
Molecular cell 44 (5), 721-733, 2011
1092011
Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
X Dai, X Bu, Y Gao, J Guo, J Hu, C Jiang, Z Zhang, K Xu, J Duan, S He, ...
Molecular cell 81 (11), 2317-2331. e6, 2021
1082021
SCFFbw7 modulates the NFκB signaling pathway by targeting NFκB2 for ubiquitination and destruction
H Fukushima, A Matsumoto, H Inuzuka, B Zhai, AW Lau, L Wan, D Gao, ...
Cell reports 1 (5), 434-443, 2012
1052012
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