Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength Y Park, JB Seo, A Fraind, A Pérez-Lara, H Yavuz, K Han, SR Jung, ... Nature structural & molecular biology 22 (10), 815-823, 2015 | 115 | 2015 |
PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium A Perez-Lara, A Thapa, SB Nyenhuis, DA Nyenhuis, P Halder, M Tietzel, ... Elife 5, e15886, 2016 | 93 | 2016 |
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex J Oroz, BJ Chang, P Wysoczanski, CT Lee, Á Pérez-Lara, P Chakraborty, ... Nature communications 9 (1), 4532, 2018 | 74 | 2018 |
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease P Lüningschrör, B Binotti, B Dombert, P Heimann, A Perez-Lara, C Slotta, ... Nature communications 8 (1), 678, 2017 | 71 | 2017 |
Curcumin Disorders 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine Membranes and Favors the Formation of Nonlamellar Structures by 1,2-Dielaidoyl-sn-glycero-3 … A Pérez-Lara, A Ausili, FJ Aranda, A de Godos, A Torrecillas, ... The Journal of Physical Chemistry B 114 (30), 9778-9786, 2010 | 54 | 2010 |
Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler CC Lin, J Seikowski, A Pérez-Lara, R Jahn, C Höbartner, PJ Walla Nature communications 5 (1), 5859, 2014 | 44 | 2014 |
Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding A Scacioc, C Schmidt, T Hofmann, H Urlaub, K Kühnel, Á Pérez-Lara Scientific reports 7 (1), 14008, 2017 | 42 | 2017 |
An overview of the synaptic vesicle lipid composition B Binotti, R Jahn, Á Pérez-Lara Archives of Biochemistry and Biophysics 709, 108966, 2021 | 40 | 2021 |
Characterization of PROPPIN-phosphoinositide binding and role of loop 6CD in PROPPIN-membrane binding RA Busse, A Scacioc, R Krick, Á Pérez-Lara, M Thumm, K Kühnel Biophysical journal 108 (9), 2223-2234, 2015 | 40 | 2015 |
Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation I Martínez-Martínez, A Ordóñez, J Navarro-Fernández, Á Pérez-Lara, ... haematologica 95 (8), 1358, 2010 | 38 | 2010 |
Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes S Wittig, M Ganzella, M Barth, S Kostmann, D Riedel, Á Pérez-Lara, ... Nature communications 12 (1), 858, 2021 | 37 | 2021 |
Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion NA Lakomek, H Yavuz, R Jahn, Á Pérez-Lara Proceedings of the National Academy of Sciences 116 (18), 8699-8708, 2019 | 36 | 2019 |
A comparison of the membrane binding properties of C1B domains of PKCγ, PKCδ, and PKCɛ S Sánchez-Bautista, S Corbalán-García, A Pérez-Lara, ... Biophysical journal 96 (9), 3638-3647, 2009 | 29 | 2009 |
Guidelines for the use and interpretation of assays for monitoring autophagy 1 D Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... Autophagy 17 (1), 1-382, 2021 | 23 | 2021 |
Phosphatidylinositol 4,5-Bisphosphate Decreases the Concentration of Ca2+, Phosphatidylserine and Diacylglycerol Required for Protein Kinase C α to Reach … AL Egea-Jimenez, A Perez-Lara, S Corbalán-García, ... PLoS One 8 (7), e69041, 2013 | 19 | 2013 |
Extended synaptotagmins (E-Syts): architecture and dynamics of membrane contact sites revealed Á Pérez-Lara, R Jahn Proceedings of the National Academy of Sciences 112 (16), 4837-4838, 2015 | 17 | 2015 |
Curcumin modulates PKCα activity by a membrane-dependent effect Á Pérez-Lara, S Corbalán-García, JC Gómez-Fernández Archives of biochemistry and biophysics 513 (1), 36-41, 2011 | 15 | 2011 |
The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition Á Pérez-Lara, AL Egea-Jiménez, A Ausili, S Corbalán-García, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2012 | 12 | 2012 |
Phosphatidylinositol-4, 5-bisphosphate enhances anionic lipid demixing by the C2 domain of PKCα AL Egea-Jimenez, AM Fernández-Martínez, A Perez-Lara, A de Godos, ... Plos one 9 (4), e95973, 2014 | 11 | 2014 |
Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin-1 -PI(4,5)P2 Interaction in Constrained Geometries J Dietz, M Oelkers, R Hubrich, A Pérez-Lara, R Jahn, C Steinem, ... Nano Letters 22 (3), 1449-1455, 2021 | 8 | 2021 |