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Mireille Khacho
Mireille Khacho
Verified email at uottawa.ca
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Year
Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program
M Khacho, A Clark, DS Svoboda, J Azzi, JG MacLaurin, C Meghaizel, ...
Cell stem cell 19 (2), 232-247, 2016
5622016
OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand
DA Patten, J Wong, M Khacho, V Soubannier, RJ Mailloux, ...
The EMBO journal 33 (22), 2676-2691, 2014
3872014
Mitochondria as central regulators of neural stem cell fate and cognitive function
M Khacho, R Harris, RS Slack
Nature Reviews Neuroscience 20 (1), 34-48, 2019
2742019
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
M Khacho, M Tarabay, D Patten, P Khacho, JG MacLaurin, J Guadagno, ...
Nature communications 5 (1), 3550, 2014
1772014
Adaptation to stressors by systemic protein amyloidogenesis
TE Audas, DE Audas, MD Jacob, JJD Ho, M Khacho, M Wang, JK Perera, ...
Developmental cell 39 (2), 155-168, 2016
1682016
Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis
M Khacho, A Clark, DS Svoboda, JG MacLaurin, DC Lagace, DS Park, ...
Human molecular genetics 26 (17), 3327-3341, 2017
1542017
Mitochondrial dynamics in the regulation of neurogenesis: from development to the adult brain
M Khacho, RS Slack
Developmental Dynamics 247 (1), 47-53, 2018
1402018
Linking mitochondrial dynamics, cristae remodeling and supercomplex formation: How mitochondrial structure can regulate bioenergetics
N Baker, J Patel, M Khacho
Mitochondrion 49, 259-268, 2019
1302019
eEF1A is a novel component of the mammalian nuclear protein export machinery
M Khacho, K Mekhail, K Pilon-Larose, A Pause, J Côté, S Lee
Molecular Biology of the Cell 19 (12), 5296-5308, 2008
1102008
Regulation of ubiquitin ligase dynamics by the nucleolus
K Mekhail, M Khacho, A Carrigan, RRJ Hache, L Gunaratnam, S Lee
The Journal of cell biology 170 (5), 733-744, 2005
1002005
Mitochondrial activity in the regulation of stem cell self-renewal and differentiation
M Khacho, RS Slack
Current opinion in cell biology 49, 1-8, 2017
832017
Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia
K Mekhail, L Rivero-Lopez, M Khacho, S Lee
Cell cycle 5 (20), 2401-2413, 2006
592006
Identification of a common subnuclear localization signal
K Mekhail, L Rivero-Lopez, A Al-Masri, C Brandon, M Khacho, S Lee
Molecular biology of the cell 18 (10), 3966-3977, 2007
472007
Oxygen sensing by H+: implications for HIF and hypoxic cell memory
K Mekhail, M Khacho, L Gunaratnam, S Lee
Cell Cycle 3 (8), 1025-1027, 2004
402004
A broad response to intracellular long-chain polyphosphate in human cells
E Bondy-Chorney, I Abramchuk, R Nasser, C Holinier, A Denoncourt, ...
Cell Reports 33 (4), 2020
382020
Mitochondrial and reactive oxygen species signaling coordinate stem cell fate decisions and life long maintenance
M Khacho, RS Slack
Antioxidants & redox signaling 28 (11), 1090-1101, 2018
372018
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
N Baker, S Wade, M Triolo, J Girgis, D Chwastek, S Larrigan, P Feige, ...
Cell Stem Cell 29 (9), 1315-1332. e9, 2022
322022
Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor
M Khacho, K Mekhail, K Pilon-Larose, J Payette, S Lee
Molecular and cellular biology 28 (1), 302-314, 2008
272008
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction
M Germain, AP Nguyen, M Khacho, DA Patten, RA Screaton, DS Park, ...
Human Molecular Genetics 22 (5), 952-962, 2013
262013
Mitophagy: A new player in stem cell biology
G Cairns, M Thumiah-Mootoo, Y Burelle, M Khacho
Biology 9 (12), 481, 2020
242020
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