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Shane Hellyer
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Year
Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation
SD Hellyer, AI Selwood, L Rhodes, DS Kerr
Toxicon 58 (8), 693-699, 2011
392011
“Selective” class CG protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands
SD Hellyer, S Albold, T Wang, ANY Chen, LT May, K Leach, KJ Gregory
Molecular Pharmacology 93 (5), 504-514, 2018
242018
Neuromuscular blocking activity of pinnatoxins E, F and G
SD Hellyer, AI Selwood, L Rhodes, DS Kerr
Toxicon 76, 214-220, 2013
212013
Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
K Sengmany, SD Hellyer, S Albold, T Wang, PJ Conn, LT May, ...
Neuropharmacology 149, 83-96, 2019
182019
Pinnatoxins E, F and G target multiple nicotinic receptor subtypes
SD Hellyer, D Indurthi, T Balle, V Runder‐Varga, AI Selwood, JDA Tyndall, ...
Journal of Neurochemistry 135 (3), 479-491, 2015
182015
Metabotropic glutamate receptor 5 (mGlu5)‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells …
SD Hellyer, S Albold, K Sengmany, J Singh, K Leach, KJ Gregory
Journal of neurochemistry 151 (3), 301-315, 2019
142019
Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation
S Hellyer, K Leach, KJ Gregory
Current Opinion in Pharmacology 32, 49-55, 2017
132017
In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative
SD Hellyer, AI Selwood, R Van Ginkel, R Munday, P Sheard, CO Miles, ...
Toxicon 87, 17-25, 2014
102014
Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site
SD Hellyer, K Sengmany, AN Keller, A Christopoulos, K Leach, ...
Biochemical pharmacology 177, 114013, 2020
82020
Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism
K Sengmany, SD Hellyer, A Christopoulos, DJ Lapinsky, K Leach, ...
Biochemical pharmacology 177, 114011, 2020
82020
Adenosine receptor signalling in Alzheimer’s disease
PNH Trinh, JA Baltos, SD Hellyer, LT May, KJ Gregory
Purinergic signalling 18 (3), 359-381, 2022
72022
Development of clickable photoaffinity ligands for metabotropic glutamate receptor 2 based on two positive allosteric modulator chemotypes
SD Hellyer, S Aggarwal, ANY Chen, K Leach, DJ Lapinsky, KJ Gregory
ACS chemical neuroscience 11 (11), 1597-1609, 2020
72020
Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5
ANY Chen, SD Hellyer, PNH Trinh, K Leach, KJ Gregory
Basic & Clinical Pharmacology & Toxicology 126, 104-115, 2020
62020
Positive allosteric modulators of metabotropic glutamate receptor 5 as tool compounds to study signaling bias
A Arsova, TC Møller, SD Hellyer, L Vedel, SR Foster, JL Hansen, ...
Molecular Pharmacology 99 (5), 328-341, 2021
52021
Mechanism of action of pinnatoxins E, F and G
SD Hellyer
University of Otago, 2014
22014
Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe-and Assay-Dependent Pharmacology
A Muraleetharan, Y Wang, MC Rowe, A Gould, KJ Gregory, SD Hellyer
Molecular Pharmacology 103 (6), 325-338, 2023
12023
Marine-derived nicotinic receptor antagonist toxins: Pinnatoxins and alpha conotoxins
SD Hellyer
Advances in Neurotoxicology 6, 105-191, 2021
12021
SCA44-and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms
Y Wang, A Muraleetharan, KJ Gregory, SD Hellyer
bioRxiv, 2023.07. 05.545810, 2023
2023
Adenosine receptor signalling in Alzheimer's disease (vol 18, pg 359, 2022)
PNH Trinh, JA Baltos, SD Hellyer, LT May, KJ Gregory
PURINERGIC SIGNALLING 18 (4), 407-407, 2022
2022
Development and use of Clickable and Irreversible Probes for Detection of G Protein‐Coupled Receptors
K Gregory, P Trinh, D Chong, S Hellyer, K Leach, B Capuano, J Tyndall, ...
The FASEB Journal 35, 2021
2021
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Articles 1–20