Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice M Gray, DI Shirasaki, C Cepeda, VM André, B Wilburn, XH Lu, J Tao, ... Journal of Neuroscience 28 (24), 6182-6195, 2008 | 736 | 2008 |
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ... Nature neuroscience 19 (4), 623-633, 2016 | 363 | 2016 |
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism O Peñagarikano, MT Lázaro, XH Lu, A Gordon, H Dong, HA Lam, E Peles, ... Science translational medicine 7 (271), 271ra8-271ra8, 2015 | 363 | 2015 |
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway MD Haustein, S Kracun, XH Lu, T Shih, O Jackson-Weaver, X Tong, J Xu, ... Neuron 82 (2), 413-429, 2014 | 252 | 2014 |
Bacterial artificial chromosome transgenic mice expressing a truncated mutant Parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and … XH Lu, SM Fleming, B Meurers, LC Ackerson, F Mortazavi, V Lo, ... Journal of Neuroscience 29 (7), 1962-1976, 2009 | 208 | 2009 |
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease N Wang, M Gray, XH Lu, JP Cantle, SM Holley, E Greiner, X Gu, ... Nature medicine 20 (5), 536-541, 2014 | 199 | 2014 |
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration J Tao, H Wu, Q Lin, W Wei, XH Lu, JP Cantle, Y Ao, RW Olsen, XW Yang, ... Journal of Neuroscience 31 (22), 8306-8319, 2011 | 191 | 2011 |
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via P13K/AKT, ERK, and pertussis toxin-sensitive pathways XH Lu, DS Dwyer Journal of Molecular Neuroscience 27, 43-64, 2005 | 131 | 2005 |
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease XH Lu, VB Mattis, N Wang, I Al-Ramahi, N van den Berg, SA Fratantoni, ... Science translational medicine 6 (268), 268ra178-268ra178, 2014 | 128 | 2014 |
Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38 XH Lu, RJ Bradley, DS Dwyer Brain research 1011 (1), 58-68, 2004 | 118 | 2004 |
Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism DS Dwyer, XH Lu, RJ Bradley Brain research 971 (1), 31-39, 2003 | 96 | 2003 |
Stomaching the possibility of a pathogenic role for Helicobacter pylori in Parkinson’s disease DJ McGee, XH Lu, EA Disbrow Journal of Parkinson's disease 8 (3), 367-374, 2018 | 78 | 2018 |
“Huntingtin holiday”: progress toward an antisense therapy for Huntington's disease XH Lu, XW Yang Neuron 74 (6), 964-966, 2012 | 62 | 2012 |
P2X4 receptor reporter mice: sparse brain expression and feeding-related presynaptic facilitation in the arcuate nucleus J Xu, AM Bernstein, A Wong, XH Lu, S Khoja, XW Yang, DL Davies, ... Journal of Neuroscience 36 (34), 8902-8920, 2016 | 58 | 2016 |
The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model MB Veldman, Y Rios-Galdamez, XH Lu, X Gu, W Qin, S Li, XW Yang, ... Molecular neurodegeneration 10, 1-16, 2015 | 45 | 2015 |
应激对中枢神经系统即刻早期基因 c-fos 表达及 HPA 轴的调节作用研究 卢晓虹, 李凌江, 李昌琦, 刘忠浩, 罗学港 中国心理卫生杂志 14 (1), 10-13, 2000 | 43 | 2000 |
Mechanistic connections between glucose/lipid disturbances and weight gain induced by antipsychotic drugs DS Dwyer, D Donohoe, XH Lu, EJ Aamodt International review of neurobiology 65, 211-247, 2005 | 40 | 2005 |
Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats J Zuo, Z Liu, X Ouyang, H Liu, Y Hao, L Xu, XH Lu Progress in Neuro-psychopharmacology and Biological Psychiatry 32 (2), 387-397, 2008 | 36 | 2008 |
Molecular and cellular basis of obsessive–compulsive disorder-like behaviors: emerging view from mouse models XW Yang, XH Lu Current opinion in neurology 24 (2), 114-118, 2011 | 35 | 2011 |
Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow M Barzegar, Y Wang, RS Eshaq, JW Yun, CJ Boyer, SG Cananzi, ... EBioMedicine 63, 2021 | 29 | 2021 |