| A stereochemical model for merged 1, 2-and 1, 3-asymmetric induction in diastereoselective Mukaiyama aldol addition reactions and related processes DA Evans, MJ Dart, JL Duffy, MG Yang Journal of the American Chemical Society 118 (18), 4322-4343, 1996 | 482 | 1996 |
| 1, 3-Asymmetric induction in the aldol addition reactions of methyl ketone enolates and enolsilanes to β-substituted aldehydes. A model for chirality transfer DA Evans, JL Duffy, MJ Dart Tetrahedron letters 35 (46), 8537-8540, 1994 | 199 | 1994 |
| Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice NB Hastings, X Wang, L Song, BD Butts, D Grotz, R Hargreaves, ... Molecular Neurodegeneration 12, 1-16, 2017 | 133 | 2017 |
| Double stereodifferentiating aldol reactions. The documentation of" partially matched" aldol bond constructions in the assemblage of polypropionate systems DA Evans, MJ Dart, JL Duffy, DL Rieger Journal of the American Chemical Society 117 (35), 9073-9074, 1995 | 126 | 1995 |
| A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects SA Qureshi, M Rios Candelore, D Xie, X Yang, LM Tota, VDH Ding, Z Li, ... Diabetes 53 (12), 3267-3273, 2004 | 124 | 2004 |
| Discovery of MK-8719, a potent O-GlcNAcase inhibitor as a potential treatment for tauopathies HG Selnick, JF Hess, C Tang, K Liu, JB Schachter, JE Ballard, J Marcus, ... Journal of medicinal chemistry 62 (22), 10062-10097, 2019 | 116 | 2019 |
| Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker C Abbadie, OB McManus, SY Sun, RM Bugianesi, G Dai, RJ Haedo, ... Journal of Pharmacology and Experimental Therapeutics 334 (2), 545-555, 2010 | 116 | 2010 |
| Diastereoselective Aldol and Allylstannane Addition Reactions. The Merged Stereochemical Impact of. alpha. and. beta. Aldehyde Substituents DA Evans, MJ Dart, JL Duffy, MG Yang, AB Livingston Journal of the American Chemical Society 117 (24), 6619-6620, 1995 | 88 | 1995 |
| Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1. 7 BS Williams, JP Felix, BT Priest, RM Brochu, K Dai, SB Hoyt, C London, ... Biochemistry 46 (50), 14693-14703, 2007 | 74 | 2007 |
| Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Cav2 calcium channels AM Swensen, J Herrington, RM Bugianesi, G Dai, RJ Haedo, KS Ratliff, ... Molecular pharmacology 81 (3), 488-497, 2012 | 72 | 2012 |
| Double stereodifferentiating Lewis acid-promoted (Mukaiyama) aldol bond constructions. DA Evans, MG Yang, MJ Dart, JL Duffy, AS Kim Journal of the American Chemical Society 117 (37), 9598-9599, 1995 | 68 | 1995 |
| Engineering glucose responsiveness into insulin NC Kaarsholm, S Lin, L Yan, T Kelly, M van Heek, J Mu, M Wu, G Dai, ... Diabetes 67 (2), 299-308, 2018 | 65 | 2018 |
| Benzazepinone Nav1. 7 blockers: potential treatments for neuropathic pain SB Hoyt, C London, H Ok, E Gonzalez, JL Duffy, C Abbadie, B Dean, ... Bioorganic & medicinal chemistry letters 17 (22), 6172-6177, 2007 | 64 | 2007 |
| On-and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl … DG Johns, J Duffy, T Fisher, BK Hubbard, MJ Forrest Drugs 72, 491-507, 2012 | 60 | 2012 |
| Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors SD Edmondson, A Mastracchio, JL Duffy, GJ Eiermann, H He, I Ita, ... Bioorganic & medicinal chemistry letters 15 (12), 3048-3052, 2005 | 60 | 2005 |
| Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor JL Duffy, BA Kirk, Z Konteatis, EL Campbell, R Liang, EJ Brady, ... Bioorganic & medicinal chemistry letters 15 (5), 1401-1405, 2005 | 60 | 2005 |
| MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy X Wang, W Li, J Marcus, M Pearson, L Song, K Smith, G Terracina, J Lee, ... Journal of Pharmacology and Experimental Therapeutics 374 (2), 252-263, 2020 | 57 | 2020 |
| 1, 3-asymmetric induction in hydride addition reactions to β-substituted ketones. A model for chirality transfer DA Evans, MJ Dart, JL Duffy Tetrahedron letters 35 (46), 8541-8544, 1994 | 48 | 1994 |
| 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes WT Ashton, CG Caldwell, JL Duffy, RJ Mathvink, L Wang, AE Weber US Patent 7,388,019, 2008 | 44 | 2008 |
| Imidazopyridines: a novel class of hNav1. 7 channel blockers C London, SB Hoyt, WH Parsons, BS Williams, VA Warren, ... Bioorganic & medicinal chemistry letters 18 (5), 1696-1701, 2008 | 44 | 2008 |
