| Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling Y Yu, SO Yoon, G Poulogiannis, Q Yang, XM Ma, J Villén, N Kubica, ... Science 332 (6035), 1322-1326, 2011 | 968 | 2011 |
| p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells RJ Ihry, KA Worringer, MR Salick, E Frias, D Ho, K Theriault, S Kommineni, ... Nature medicine 24 (7), 939-946, 2018 | 936 | 2018 |
| Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI GR Hoffman, N Nassar, RA Cerione Cell 100 (3), 345-356, 2000 | 674 | 2000 |
| Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening ER McDonald, A De Weck, MR Schlabach, E Billy, KJ Mavrakis, ... Cell 170 (3), 577-592. e10, 2017 | 597 | 2017 |
| DNA repair profiling reveals nonrandom outcomes at Cas9-mediated breaks M van Overbeek, D Capurso, MM Carter, MS Thompson, E Frias, C Russ, ... Molecular cell 63 (4), 633-646, 2016 | 484 | 2016 |
| Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 KJ Mavrakis, ER McDonald III, MR Schlabach, E Billy, GR Hoffman, ... Science 351 (6278), 1208-1213, 2016 | 426 | 2016 |
| Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers GR Hoffman, R Rahal, F Buxton, K Xiang, G McAllister, E Frias, ... Proceedings of the National Academy of Sciences 111 (8), 3128-3133, 2014 | 399 | 2014 |
| Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP N Nassar, GR Hoffman, D Manor, JC Clardy, RA Cerione Nature structural biology 5 (12), 1047-1052, 1998 | 279 | 1998 |
| A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions MM Lipinski, G Hoffman, A Ng, W Zhou, BF Py, E Hsu, X Liu, J Eisenberg, ... Developmental cell 18 (6), 1041-1052, 2010 | 245 | 2010 |
| Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex SG Kim, GR Hoffman, G Poulogiannis, GR Buel, YJ Jang, KW Lee, ... Molecular cell 49 (1), 172-185, 2013 | 230 | 2013 |
| Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy CH Eng, Z Wang, D Tkach, L Toral-Barza, S Ugwonali, S Liu, ... Proceedings of the National Academy of Sciences 113 (1), 182-187, 2016 | 222 | 2016 |
| Signaling to the Rho GTPases: networking with the DH domain GR Hoffman, RA Cerione FEBS letters 513 (1), 85-91, 2002 | 189 | 2002 |
| YAP, but not RSPO-LGR4/5, signaling in biliary epithelial cells promotes a ductular reaction in response to liver injury L Planas-Paz, T Sun, M Pikiolek, NR Cochran, S Bergling, V Orsini, ... Cell stem cell 25 (1), 39-53. e10, 2019 | 174 | 2019 |
| Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9 JM Goodwin, WE Dowdle, R DeJesus, Z Wang, P Bergman, M Kobylarz, ... Cell reports 20 (10), 2341-2356, 2017 | 142 | 2017 |
| Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 R DeJesus, F Moretti, G McAllister, Z Wang, P Bergman, S Liu, E Frias, ... Elife 5, e17290, 2016 | 140 | 2016 |
| TMEM 41B is a novel regulator of autophagy and lipid mobilization F Moretti, P Bergman, S Dodgson, D Marcellin, I Claerr, JM Goodwin, ... EMBO reports 19 (9), e45889, 2018 | 138 | 2018 |
| Flipping the switch: minireview the structural basis for signaling through the CRIB motif GR Hoffman, RA Cerione Cell 102 (4), 403-406, 2000 | 98 | 2000 |
| Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy C Potting, C Crochemore, F Moretti, F Nigsch, I Schmidt, C Manneville, ... Proceedings of the National Academy of Sciences 115 (2), E180-E189, 2018 | 96 | 2018 |
| Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia C Dafflon, VJ Craig, H Mereau, J Gräsel, B Schacher Engstler, G Hoffman, ... Leukemia 31 (6), 1269-1277, 2017 | 95 | 2017 |
| ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor Z Mounir, JM Korn, T Westerling, F Lin, CA Kirby, M Schirle, G McAllister, ... Elife 5, e13964, 2016 | 77 | 2016 |
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerified email at med.cornell.edu
