Structural basis of selective inhibition of human tankyrases M Narwal, H Venkannagari, L Lehtio Journal of medicinal chemistry 55 (3), 1360-1367, 2012 | 155 | 2012 |
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity M Narwal, J Koivunen, T Haikarainen, E Obaji, OE Legala, ... Journal of medicinal chemistry 56 (20), 7880-7889, 2013 | 64 | 2013 |
Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage H Venkannagari, P Verheugd, J Koivunen, T Haikarainen, E Obaji, ... Cell chemical biology 23 (10), 1251-1260, 2016 | 56 | 2016 |
Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors H Venkannagari, A Fallarero, KLH Feijs, B Lüscher, L Lehtiö European Journal of Pharmaceutical Sciences 49 (2), 148-156, 2013 | 52 | 2013 |
para‐Substituted 2‐Phenyl‐3,4‐dihydroquinazolin‐4‐ones As Potent and Selective Tankyrase Inhibitors T Haikarainen, J Koivunen, M Narwal, H Venkannagari, E Obaji, ... ChemMedChem 8 (12), 1978-1985, 2013 | 44 | 2013 |
Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4 T Haikarainen, H Venkannagari, M Narwal, E Obaji, HW Lee, Y Nkizinkiko, ... PloS one 8 (6), e65404, 2013 | 38 | 2013 |
Development and structural analysis of adenosine site binding tankyrase inhibitors T Haikarainen, J Waaler, A Ignatev, Y Nkizinkiko, H Venkannagari, ... Bioorganic & Medicinal Chemistry Letters 26 (2), 328-333, 2016 | 29 | 2016 |
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics Y Nkizinkiko, BVSS Kumar, VU Jeankumar, T Haikarainen, J Koivunen, ... Bioorganic & Medicinal Chemistry 23 (15), 4139-4149, 2015 | 25 | 2015 |
Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite SC Vilchez Larrea, T Haikarainen, M Narwal, M Schlesinger, ... Public Library of Science 7 (9), e46063, 2012 | 25 | 2012 |
4-(Phenoxy) and 4-(benzyloxy) benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10 S Murthy, J Desantis, P Verheugd, MM Maksimainen, H Venkannagari, ... European journal of medicinal chemistry 156, 93-102, 2018 | 24 | 2018 |
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei M Schlesinger, SC Vilchez Larrea, T Haikarainen, M Narwal, ... Parasites & vectors 9, 1-15, 2016 | 16 | 2016 |
Highly conserved molecular features in IgLONs contrast their distinct structural and biological outcomes H Venkannagari, JM Kasper, A Misra, SA Rush, S Fan, H Lee, H Sun, ... Journal of molecular biology 432 (19), 5287-5303, 2020 | 15 | 2020 |
Adenosine analogs bearing phosphate isosteres as human MDO1 ligands Y Zhang, M Jumppanen, MM Maksimainen, S Auno, Z Awol, L Ghemtio, ... Bioorganic & Medicinal Chemistry 26 (8), 1588-1597, 2018 | 10 | 2018 |
[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes S Murthy, MG Nizi, MM Maksimainen, S Massari, J Alaviuhkola, BE Lippok, ... Journal of Medicinal Chemistry 66 (2), 1301-1320, 2023 | 5 | 2023 |
Self-assembly of the bZIP transcription factor ΔFosB Z Yin, H Venkannagari, H Lynch, G Aglyamova, M Bhandari, M Machius, ... Current research in structural biology 2, 1-13, 2020 | 5 | 2020 |
Architecture of the baculovirus nucleocapsid revealed by cryo-EM X Jia, Y Gao, Y Huang, L Sun, S Li, H Li, X Zhang, Y Li, J He, W Wu, ... Nature Communications 14 (1), 7481, 2023 | 2 | 2023 |
Compounds for use in the treatment of cancer L Lehtiö, H Venkannagari, B Lüscher, P Verheugd US Patent 11,096,909, 2021 | 1 | 2021 |
Predictive modeling and cryo-EM: A synergistic approach to modeling macromolecular structure MR Corum, H Venkannagari, CF Hryc, ML Baker Biophysical Journal 123 (4), 435-450, 2024 | | 2024 |
Compounds for use in the treatment of cancer L Lehtiö, H Venkannagari, B Lüscher, P Verheugd US Patent App. 17/380,195, 2021 | | 2021 |
NEGR1, an IgLON Implicated in Human Obesity, Shares a Conserved 3D Structure and Interaction Mode With Other IgLONs, but Uniquely Impacts Feeding H Venkannagari, JJ Kasper, A Misra, M Machius, J Hommel, G Rudenko NEUROPSYCHOPHARMACOLOGY 44 (SUPPL 1), 157-158, 2019 | | 2019 |