| Heme binds to a short sequence that serves a regulatory function in diverse proteins. L Zhang, L Guarente The EMBO journal 14 (2), 313-320, 1995 | 370 | 1995 |
| Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases SM Mense, L Zhang Cell research 16 (8), 681-692, 2006 | 358 | 2006 |
| DNA supercoiling promotes formation of a bent repression loop in lac DNA JA Borowiec, L Zhang, S Sasse-Dwight, JD Gralla Journal of molecular biology 196 (1), 101-111, 1987 | 297 | 1987 |
| Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes J Hooda, A Shah, L Zhang Nutrients 6 (3), 1080-1102, 2014 | 241 | 2014 |
| Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator L Zhang, A Hach Cellular and Molecular Life Sciences CMLS 56, 415-426, 1999 | 225 | 1999 |
| Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes SM Mense, A Sengupta, M Zhou, C Lan, G Bentsman, DJ Volsky, L Zhang Physiological genomics 25 (3), 435-449, 2006 | 161 | 2006 |
| Mitochondria targeting as an effective strategy for cancer therapy P Ghosh, C Vidal, S Dey, L Zhang International journal of molecular sciences 21 (9), 3363, 2020 | 159 | 2020 |
| The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes SM Mense, A Sengupta, C Lan, M Zhou, G Bentsman, DJ Volsky, ... Toxicological Sciences 93 (1), 125-135, 2006 | 129 | 2006 |
| Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1 L Zhang, A Hach, C Wang Molecular and cellular biology 18 (7), 3819-3828, 1998 | 125 | 1998 |
| Structure of a HAP1–DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein DA King, L Zhang, L Guarente, R Marmorstein Nature structural biology 6 (1), 64-71, 1999 | 124 | 1999 |
| Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells J Hooda, D Cadinu, MM Alam, A Shah, TM Cao, LA Sullivan, R Brekken, ... PloS one 8 (5), e63402, 2013 | 112 | 2013 |
| The yeast activator HAP1--a GAL4 family member--binds DNA in a directly repeated orientation. L Zhang, L Guarente Genes & Development 8 (17), 2110-2119, 1994 | 111 | 1994 |
| A mechanism of oxygen sensing in yeast: multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity T Hon, A Dodd, R Dirmeier, N Gorman, PR Sinclair, L Zhang, RO Poyton Journal of Biological Chemistry 278 (50), 50771-50780, 2003 | 105 | 2003 |
| A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors MM Alam, S Lal, KE FitzGerald, L Zhang Clinical and translational medicine 5, 1-14, 2016 | 98 | 2016 |
| Heme deficiency interferes with the Ras-mitogen-activated protein kinase signaling pathway and expression of a subset of neuronal genes Y Zhu, T Hon, W Ye, L Zhang | 90 | 2002 |
| Heme biology: the secret life of heme in regulating diverse biological processes L Zhang World scientific, 2011 | 83 | 2011 |
| The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation RG Dastidar, J Hooda, A Shah, TM Cao, RM Henke, L Zhang Cell & bioscience 2, 1-13, 2012 | 80 | 2012 |
| In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site. L Zhang, JD Gralla Genes & development 3 (11), 1814-1822, 1989 | 79 | 1989 |
| HAP1 is nuclear but is bound to a cellular factor in the absence of heme. L Zhang, L Guarente Journal of Biological Chemistry 269 (20), 14643-14647, 1994 | 74 | 1994 |
| A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex C Lan, HC Lee, S Tang, L Zhang Journal of Biological Chemistry 279 (26), 27607-27612, 2004 | 70 | 2004 |
Christina LeslieMemorial Sloan Kettering Cancer CenterVerified email at mskcc.org
