| Amyloid beta: structure, biology and structure-based therapeutic development G Chen, T Xu, Y Yan, Y Zhou, Y Jiang, K Melcher, HE Xu Acta Pharmacologica Sinica 38 (9), 1205-1235, 2017 | 1610 | 2017 |
| EZH2: biology, disease, and structure-based drug discovery J Tan, Y Yan, X Wang, Y Jiang, HE Xu Acta Pharmacologica Sinica 35 (2), 161-174, 2014 | 240 | 2014 |
| Structure and physiological regulation of AMPK Y Yan, XE Zhou, HE Xu, K Melcher International journal of molecular sciences 19 (11), 3534, 2018 | 192 | 2018 |
| Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio TH Xu, Y Yan, Y Kang, Y Jiang, K Melcher, HE Xu Cell Discovery 2 (1), 1-14, 2016 | 101 | 2016 |
| Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms SL Pinkosky, JW Scott, EM Desjardins, BK Smith, EA Day, RJ Ford, ... Nature metabolism 2 (9), 873-881, 2020 | 92 | 2020 |
| Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing X Gu, Y Yan, SJ Novick, A Kovach, D Goswami, J Ke, MHE Tan, L Wang, ... Journal of Biological Chemistry 292 (30), 12653-12666, 2017 | 52 | 2017 |
| Structure of an AMPK complex in an inactive, ATP-bound state Y Yan, S Mukherjee, KG Harikumar, TS Strutzenberg, XE Zhou, ... Science 373 (6553), 413-419, 2021 | 48 | 2021 |
| Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites Y Yan, TH Xu, KG Harikumar, LJ Miller, K Melcher, HE Xu Journal of Biological Chemistry 292 (38), 15826-15837, 2017 | 37 | 2017 |
| Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states Y Yan, XE Zhou, SJ Novick, SJ Shaw, Y Li, JS Brunzelle, Y Hitoshi, ... Journal of Biological Chemistry 294 (3), 953-967, 2019 | 33 | 2019 |
| Defining the minimum substrate and charge recognition model of gamma-secretase Y Yan, TH Xu, K Melcher, HE Xu Acta Pharmacologica Sinica 38 (10), 1412-1424, 2017 | 29 | 2017 |
| Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK) X Gu, MD Bridges, Y Yan, PW de Waal, XE Zhou, KM Suino-Powell, ... Journal of Biological Chemistry 293 (44), 16994-17007, 2018 | 19 | 2018 |
| Bioluminescence resonance energy transfer (BRET) assay for determination of molecular interactions in living cells KG Harikumar, Y Yan, TH Xu, K Melcher, HE Xu, LJ Miller Bio-protocol 7 (22), e2904-e2904, 2017 | 10 | 2017 |
| A highly sensitive non-radioactive activity assay for AMP-activated protein kinase (AMPK) Y Yan, X Gu, HE Xu, K Melcher Methods and protocols 1 (1), 3, 2017 | 7 | 2017 |
| Streptavidin bead pulldown assay to determine protein homooligomerization TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu Bio-protocol 7 (22), e2901-e2901, 2017 | 5 | 2017 |
| Detection of membrane protein interactions by cell-based tango assays Y Yan, TH Xu, KG Harikumar, LJ Miller, K Melcher, HE Xu Bio-protocol 7 (22), e2903-e2903, 2017 | 2 | 2017 |
| γ-Secretase Epsilon-cleavage Assay TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu Bio-protocol 7 (22), e2900-e2900, 2017 | | 2017 |
