Chemical genetics of Plasmodium falciparum WA Guiguemde, AA Shelat, D Bouck, S Duffy, GJ Crowther, PH Davis, ... Nature 465 (7296), 311-315, 2010 | 644 | 2010 |
A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 431 | 2015 |
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria MA Phillips, J Lotharius, K Marsh, J White, A Dayan, KL White, ... Science translational medicine 7 (296), 296ra111-296ra111, 2015 | 321 | 2015 |
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors … JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, ... Journal of medicinal chemistry 54 (15), 5540-5561, 2011 | 318 | 2011 |
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium MB Jiménez-Díaz, D Ebert, Y Salinas, A Pradhan, AM Lehane, ... Proceedings of the National Academy of Sciences 111 (50), E5455-E5462, 2014 | 259 | 2014 |
Quinolone-3-diarylethers: a new class of antimalarial drug A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ... Science translational medicine 5 (177), 177ra37-177ra37, 2013 | 245 | 2013 |
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), eaad9735, 2017 | 243 | 2017 |
A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes I Angulo-Barturen, MB Jiménez-Díaz, T Mulet, J Rullas, E Herreros, ... PloS one 3 (5), e2252, 2008 | 188 | 2008 |
Genetic analysis of the chitinase system of Serratia marcescens 2170 T Watanabe, K Kimura, T Sumiya, N Nikaidou, K Suzuki, M Suzuki, ... Journal of bacteriology 179 (22), 7111-7117, 1997 | 175 | 1997 |
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum AB Vaidya, JM Morrisey, Z Zhang, S Das, TM Daly, TD Otto, NJ Spillman, ... Nature communications 5 (1), 5521, 2014 | 150 | 2014 |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission DA Baker, LB Stewart, JM Large, PW Bowyer, KH Ansell, ... Nature communications 8 (1), 430, 2017 | 126 | 2017 |
Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series JM Coteron, D Catterick, J Castro, MJ Chaparro, B Díaz, E Fernández, ... Journal of medicinal chemistry 53 (16), 6129-6152, 2010 | 120 | 2010 |
Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia T Gumbo, I Angulo-Barturen, S Ferrer-Bazaga The Journal of infectious diseases 211 (suppl_3), S96-S106, 2015 | 115 | 2015 |
Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia T Gumbo, I Angulo-Barturen, S Ferrer-Bazaga The Journal of infectious diseases 211 (suppl_3), S96-S106, 2015 | 115 | 2015 |
High seroprevalence of Pneumocystis infection in Spanish children N Respaldiza, FJ Medrano, AC Medrano, JM Varela, C De La Horra, ... Clinical microbiology and infection 10 (11), 1029-1031, 2004 | 99 | 2004 |
Repurposing clinically approved cephalosporins for tuberculosis therapy S Ramón-García, R González del Río, AS Villarejo, GD Sweet, ... Scientific reports 6 (1), 34293, 2016 | 88 | 2016 |
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with improved drug-like properties for treatment and prevention of malaria MA Phillips, KL White, S Kokkonda, X Deng, J White, F El Mazouni, ... ACS infectious diseases 2 (12), 945-957, 2016 | 85 | 2016 |
Polyphasic taxonomy of a novel yeast isolated from antarctic environment; description of Cryptococcus victoriae sp. nov. MJ Montes, C Belloch, M Galiana, MD Garcia, C Andrés, S Ferrer, ... Systematic and applied microbiology 22 (1), 97-105, 1999 | 71 | 1999 |
Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1 JM Bueno, E Herreros, I Angulo-Barturen, S Ferrer, JM Fiandor, FJ Gamo, ... Future medicinal chemistry 4 (18), 2311-2323, 2012 | 70 | 2012 |
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance PM O’Neill, RK Amewu, SA Charman, S Sabbani, NF Gnädig, J Straimer, ... Nature Communications 8 (1), 15159, 2017 | 67 | 2017 |