| Biological significance of unwinding capability of nuclear matrix-associating DNAs J Bode, Y Kohwi, L Dickinson, T Joh, D Klehr, C Mielke, ... Science 255 (5041), 195-197, 1992 | 555 | 1992 |
| Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci T Schlake, J Bode Biochemistry 33 (43), 12746-12751, 1994 | 448 | 1994 |
| A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells C Piechaczek, C Fetzer, A Baiker, J Bode, HJ Lipps Nucleic acids research 27 (2), 426-428, 1999 | 291 | 1999 |
| Transcriptional augmentation: modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements) J Bode, C Benham, A Knopp, C Mielke Critical Reviews™ in Eukaryotic Gene Expression 10 (1), 2000 | 290 | 2000 |
| Chromatin loops are selectively anchored using scaffold/matrix-attachment regions HHQ Heng, S Goetze, CJ Ye, G Liu, JB Stevens, SW Bremer, SM Wykes, ... Journal of cell science 117 (7), 999-1008, 2004 | 266 | 2004 |
| Scaffold-attached regions from the human interferon. beta. domain can be used to enhance the stable expression of genes under the control of various promoters D Klehr, K Maass, J Bode Biochemistry 30 (5), 1264-1270, 1991 | 258 | 1991 |
| Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenes A Baer, J Bode Current opinion in biotechnology 12 (5), 473-480, 2001 | 236 | 2001 |
| Optimized signal peptides for the development of high expressing CHO cell lines L Kober, C Zehe, J Bode Biotechnology and bioengineering 110 (4), 1164-1173, 2013 | 228 | 2013 |
| Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome ACW Jenke, IM Stehle, F Herrmann, T Eisenberger, A Baiker, J Bode, ... Proceedings of the National Academy of Sciences 101 (31), 11322-11327, 2004 | 214 | 2004 |
| Scaffold/matrix-attached regions: structural properties creating transcriptionally active loci J Bode, T Schlake, M Rios-Ramirez, C Mielke, M Stengert, V Kay, ... International review of cytology 162, 389-454, 1996 | 201 | 1996 |
| Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges S Turan, M Galla, E Ernst, J Qiao, C Voelkel, B Schiedlmeier, C Zehe, ... Journal of molecular biology 407 (2), 193-221, 2011 | 200 | 2011 |
| Chromatin domain surrounding the human interferon-. beta. gene as defined by scaffold-attached regions J Bode, K Maass Biochemistry 27 (13), 4706-4711, 1988 | 200 | 1988 |
| Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix A Baiker, C Maercker, C Piechaczek, SBA Schmidt, J Bode, C Benham, ... Nature cell biology 2 (3), 182-184, 2000 | 189 | 2000 |
| Recombinase-mediated cassette exchange (RMCE)—a rapidly-expanding toolbox for targeted genomic modifications S Turan, C Zehe, J Kuehle, J Qiao, J Bode Gene 515 (1), 1-27, 2013 | 185 | 2013 |
| Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo C Mielke, Y Kohwi, T Kohwi-Shigematsu, J Bode Biochemistry 29 (32), 7475-7485, 1990 | 179 | 1990 |
| Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions C Benham, T Kohwi-Shigematsu, JÈ Bode Journal of molecular biology 274 (2), 181-196, 1997 | 178 | 1997 |
| Scaffold/matrix-attached regions: topological switches with multiple regulatory functions J Bode, M Stengert-lber, V Kay, T Schlake, A Dietz-Pfeilstetter Critical Reviews™ in Eukaryotic Gene Expression 6 (2-3), 1996 | 173 | 1996 |
| Protein transduction from retroviral Gag precursors C Voelkel, M Galla, T Maetzig, E Warlich, J Kuehle, D Zychlinski, J Bode, ... Proceedings of the National Academy of Sciences 107 (17), 7805-7810, 2010 | 162 | 2010 |
| The Transgeneticists toolbox: novel methods for the targeted modification of eukaryotic genomes J Bode, T Schlake, M Iber, D Schübeler, J Seibler, E Snezhkov, ... Walter de Gruyter 381 (9-10), 801-813, 2000 | 153 | 2000 |
| Neural networks for cost estimation J Bode Cost engineering 40 (1), 25, 1998 | 147 | 1998 |
Dirk SchübelerDirector, Friedrich Miescher Institute for Biomedical Research, Basel, SwitzerlandVerified email at fmi.ch
