| T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition E Hui, J Cheung, J Zhu, X Su, MJ Taylor, HA Wallweber, DK Sasmal, ... Science 355 (6332), 1428-1433, 2017 | 1517 | 2017 |
| Phase separation of signaling molecules promotes T cell receptor signal transduction X Su, JA Ditlev, E Hui, W Xing, S Banjade, J Okrut, DS King, J Taunton, ... Science 352 (6285), 595-599, 2016 | 1010 | 2016 |
| Synaptotagmin-mediated bending of the target membrane is a critical step in Ca2+-regulated fusion E Hui, CP Johnson, J Yao, FM Dunning, ER Chapman Cell 138 (4), 709-721, 2009 | 324 | 2009 |
| PD-L1: CD80 cis-heterodimer triggers the co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 pathways Y Zhao, CK Lee, CH Lin, RB Gassen, X Xu, Z Huang, C Xiao, C Bonorino, ... Immunity 51 (6), 1059-1073. e9, 2019 | 273 | 2019 |
| Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+ MC Chicka, E Hui, H Liu, ER Chapman Nature structural & molecular biology 15 (8), 827-835, 2008 | 236 | 2008 |
| Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis E Hui, J Bai, P Wang, M Sugimori, RR Llinas, ER Chapman Proceedings of the National Academy of Sciences 102 (14), 5210-5214, 2005 | 233 | 2005 |
| Ca2+ and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes C Czibener, NM Sherer, SM Becker, M Pypaert, E Hui, ER Chapman, ... The Journal of cell biology 174 (7), 997-1007, 2006 | 177 | 2006 |
| Antigen-presenting cell-intrinsic PD-1 neutralizes PD-L1 in cis to attenuate PD-1 signaling in T cells Y Zhao, DL Harrison, Y Song, J Ji, J Huang, E Hui Cell reports 24 (2), 379-390. e6, 2018 | 168 | 2018 |
| In vitro membrane reconstitution of the T-cell receptor proximal signaling network E Hui, RD Vale Nature structural & molecular biology 21 (2), 133-142, 2014 | 157 | 2014 |
| Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses KL Banta, X Xu, AS Chitre, A Au-Yeung, C Takahashi, WE O’Gorman, ... Immunity 55 (3), 512-526. e9, 2022 | 148 | 2022 |
| Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment H Liu, H Bai, E Hui, L Yang, CS Evans, Z Wang, SE Kwon, ER Chapman Elife 3, e01524, 2014 | 127 | 2014 |
| Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I E Hui, J Bai, ER Chapman Biophysical journal 91 (5), 1767-1777, 2006 | 124 | 2006 |
| Multiple signaling roles of CD3ε and its application in CAR-T cell therapy W Wu, Q Zhou, T Masubuchi, X Shi, H Li, X Xu, M Huang, L Meng, X He, ... Cell 182 (4), 855-871. e23, 2020 | 116 | 2020 |
| In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase CB Carbone, N Kern, RA Fernandes, E Hui, X Su, KC Garcia, RD Vale Proceedings of the National Academy of Sciences 114 (44), E9338-E9345, 2017 | 97 | 2017 |
| Mechanism and function of synaptotagmin-mediated membrane apposition E Hui, JD Gaffaney, Z Wang, CP Johnson, CS Evans, ER Chapman Nature structural & molecular biology 18 (7), 813-821, 2011 | 92 | 2011 |
| PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2 X Xu, B Hou, A Fulzele, T Masubuchi, Y Zhao, Z Wu, Y Hu, Y Jiang, Y Ma, ... Journal of Cell Biology 219 (6), e201905085, 2020 | 90 | 2020 |
| Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis JD Gaffaney, FM Dunning, Z Wang, E Hui, ER Chapman Journal of biological chemistry 283 (46), 31763-31775, 2008 | 84 | 2008 |
| A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores CW Chang, E Hui, J Bai, D Bruns, ER Chapman, MB Jackson Journal of Neuroscience 35 (14), 5772-5780, 2015 | 61 | 2015 |
| Phosphatidylserine Regulation of Ca2+-triggered Exocytosis and Fusion Pores in PC12 Cells Z Zhang, E Hui, ER Chapman, MB Jackson Molecular Biology of the Cell 20 (24), 5086-5095, 2009 | 54 | 2009 |
| Immune checkpoint inhibitors E Hui Journal of cell Biology 218 (3), 740-741, 2019 | 51 | 2019 |
