| Mechanism of foreign DNA selection in a bacterial adaptive immune system DG Sashital, B Wiedenheft, JA Doudna Molecular cell 46 (5), 606-615, 2012 | 425 | 2012 |
| An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3 DG Sashital, M Jinek, JA Doudna Nature structural & molecular biology 18 (6), 680-687, 2011 | 339 | 2011 |
| The revolution continues: newly discovered systems expand the CRISPR-Cas toolkit K Murugan, K Babu, R Sundaresan, R Rajan, DG Sashital Molecular cell 68 (1), 15-25, 2017 | 207 | 2017 |
| U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction DG Sashital, G Cornilescu, SE Butcher Nature structural & molecular biology 11 (12), 1237-1242, 2004 | 175 | 2004 |
| Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif RKO Sigel, DG Sashital, DL Abramovitz, AG Palmer III, SE Butcher, ... Nature structural & molecular biology 11 (2), 187-192, 2004 | 127 | 2004 |
| Structural insights into RNA interference DG Sashital, JA Doudna Current opinion in structural biology 20 (1), 90-97, 2010 | 117 | 2010 |
| CRISPR interference and priming varies with individual spacer sequences C Xue, AS Seetharam, O Musharova, K Severinov, SJ J. Brouns, ... Nucleic acids research 43 (22), 10831-10847, 2015 | 116 | 2015 |
| Cas4-dependent prespacer processing ensures high-fidelity programming of CRISPR arrays H Lee, Y Zhou, DW Taylor, DG Sashital Molecular cell 70 (1), 48-59. e5, 2018 | 106 | 2018 |
| CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects K Murugan, AS Seetharam, AJ Severin, DG Sashital Journal of Biological Chemistry 295 (17), 5538-5553, 2020 | 105 | 2020 |
| Structure of the yeast U2/U6 snRNA complex JE Burke, DG Sashital, X Zuo, YX Wang, SE Butcher Rna 18 (4), 673-683, 2012 | 97 | 2012 |
| Achieving plant CRISPR targeting that limits off‐target effects JD Wolt, K Wang, D Sashital, CJ Lawrence‐Dill The plant genome 9 (3), plantgenome2016.05.0047, 2016 | 91 | 2016 |
| Pathogen detection in the CRISPR–Cas era DG Sashital Genome medicine 10 (1), 32, 2018 | 85 | 2018 |
| The Cas4-Cas1-Cas2 complex mediates precise prespacer processing during CRISPR adaptation H Lee, Y Dhingra, DG Sashital Elife 8, e44248, 2019 | 81 | 2019 |
| High-frequency random DNA insertions upon co-delivery of CRISPR-Cas9 ribonucleoprotein and selectable marker plasmid in rice R Banakar, AL Eggenberger, K Lee, DA Wright, K Murugan, S Zarecor, ... Scientific Reports 9 (1), 19902, 2019 | 78 | 2019 |
| A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli DG Sashital, CA Greeman, D Lyumkis, CS Potter, B Carragher, ... Elife 3, e04491, 2014 | 75 | 2014 |
| Conformational control of cascade interference and priming activities in CRISPR immunity C Xue, NR Whitis, DG Sashital Molecular cell 64 (4), 826-834, 2016 | 66 | 2016 |
| Mechanisms of Type I-E and I-F CRISPR-Cas Systems in Enterobacteriaceae C Xue, DG Sashital EcoSal plus 8 (2), 10.1128/ecosalplus. ESP-0008-2018, 2019 | 54 | 2019 |
| Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human DG Sashital, V Venditti, CG Angers, G Cornilescu, SE Butcher Rna 13 (3), 328-338, 2007 | 53 | 2007 |
| Structural Basis for a Lethal Mutation in U6 RNA, DG Sashital, AM Allmann, SR Van Doren, SE Butcher Biochemistry 42 (6), 1470-1477, 2003 | 47 | 2003 |
| Real-time observation of target search by the CRISPR surveillance complex cascade C Xue, Y Zhu, X Zhang, YK Shin, DG Sashital Cell reports 21 (13), 3717-3727, 2017 | 45 | 2017 |
Samuel E. ButcherProfessor of Biochemistry, University of Wisconsin-MadisonVerified email at wisc.edu
