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Simbarashe P Zvada
Simbarashe P Zvada
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High-dose rifapentine with moxifloxacin for pulmonary tuberculosis
A Jindani, TS Harrison, AJ Nunn, PPJ Phillips, GJ Churchyard, ...
New England Journal of Medicine 371 (17), 1599-1608, 2014
4942014
CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an …
M Dhoro, S Zvada, B Ngara, C Nhachi, G Kadzirange, P Chonzi, ...
BMC Pharmacology and Toxicology 16, 1-10, 2015
882015
Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses
SP Zvada, P Denti, PR Donald, HS Schaaf, S Thee, JA Seddon, HI Seifart, ...
Journal of Antimicrobial Chemotherapy 69 (5), 1339-1349, 2014
762014
Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients
SP Zvada, P Denti, FA Sirgel, E Chigutsa, M Hatherill, S Charalambous, ...
Antimicrobial agents and chemotherapy 58 (1), 503-510, 2014
562014
Effects of four different meal types on the population pharmacokinetics of single-dose rifapentine in healthy male volunteers
SP Zvada, JS Van Der Walt, PJ Smith, PB Fourie, G Roscigno, ...
Antimicrobial agents and chemotherapy 54 (8), 3390-3394, 2010
452010
Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine
SP Zvada, P Denti, H Geldenhuys, S Meredith, D van As, M Hatherill, ...
Antimicrobial agents and chemotherapy 56 (8), 4471-4473, 2012
392012
In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug …
RS Thelingwani, SP Zvada, H Dolgos, ALB Ungell, CM Masimirembwa
Drug metabolism and disposition 37 (6), 1286-1294, 2009
362009
Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa
G Pillai, G Davies, P Denti, JL Steimer, H McIlleron, S Zvada, E Chigutsa, ...
CPT: pharmacometrics & systems pharmacology 2 (8), 1-4, 2013
232013
A population pharmacokinetic analysis shows that arylacetamide deacetylase (AADAC) gene polymorphism and HIV infection affect the exposure of rifapentine
J Francis, SP Zvada, P Denti, M Hatherill, S Charalambous, S Mungofa, ...
Antimicrobial agents and chemotherapy 63 (4), 10.1128/aac. 01964-18, 2019
172019
Does hepatic impairment affect the exposure of monoclonal antibodies?
Q Sun, S Seo, S Zvada, C Liu, K Reynolds
Clinical Pharmacology & Therapeutics 107 (5), 1256-1262, 2020
152020
A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir: a study of HIV-infected Zimbabwean adolescents
B Ngara, S Zvada, TD Chawana, B Stray-Pedersen, CFB Nhachi, ...
BMC Pharmacology and Toxicology 21, 1-9, 2020
42020
Population pharmacokinetics of rifampicin in childhood tuberculosis and the need for dose adjustment
SP Zvada, USH Simonsson, P Denti, PR Donald, HS Schaaf, PJ Smith, ...
Abstract book; 3rd International Workshop on Clinical Pharmacology of …, 2010
22010
An experimental pharmacokinetic computer program to predict potential drug-drug interactions
SP Zvada, TE Chagwedera, R Chigwanda, CM Masimirembwa
The Open Drug Metabolism Journal 3 (1), 2009
22009
Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe
B Ngara, S Zvada, TD Chawana, CFB Nhachi, S Rusakaniko
BMC Pharmacology and Toxicology 22 (1), 29, 2021
2021
Arylacetamide deacetylase (AADAC) gene polymorphism and HIV infection 3 affect the exposure of Rifapentine: a population pharmacokinetics analysis. 4
J Francis, SP Zvada, P Denti, M Hatherill, S Charalambous, S Mungofa, ...
2019
IDENTIFICATION OF DOSE AND DURATION OF PTH1-34 ADMINISTRATION SUITABLE FOR USE IN PROOF OF CONCEPT STUDIES USING MODELING AND SIMULATION
S Zvada, B Thomas, G Pillai, C Zhang, P Denti
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 115, 264-265, 2014
2014
Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
SP Zvada
2014
2024 Rome, Italy
B Francis, SP Zvada, P Denti, M Hatherill, S Charalambous, S Mungofa, ...
Population Approach Group Europe Population Approach Group Europe
T Dorlo
Population Approach Group Europe Population Approach Group Europe
R Keizer
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