Histone H3K27ac separates active from poised enhancers and predicts developmental state MP Creyghton, AW Cheng, GG Welstead, T Kooistra, BW Carey, ... Proceedings of the National Academy of Sciences 107 (50), 21931-21936, 2010 | 4525 | 2010 |
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering H Wang, H Yang, CS Shivalila, MM Dawlaty, AW Cheng, F Zhang, ... Cell 153 (4), 910-918, 2013 | 4444 | 2013 |
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering H Yang, H Wang, CS Shivalila, AW Cheng, L Shi, R Jaenisch Cell 154 (6), 1370-1379, 2013 | 1988 | 2013 |
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells X Wu, DA Scott, AJ Kriz, AC Chiu, PD Hsu, DB Dadon, AW Cheng, ... Nature biotechnology 32 (7), 670-676, 2014 | 1185 | 2014 |
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs J Hanna, AW Cheng, K Saha, J Kim, CJ Lengner, F Soldner, JP Cassady, ... Proceedings of the National Academy of Sciences 107 (20), 9222-9227, 2010 | 1029 | 2010 |
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system AW Cheng, H Wang, H Yang, L Shi, Y Katz, TW Theunissen, ... Cell research 23 (10), 1163-1171, 2013 | 983 | 2013 |
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase Y Buganim, DA Faddah, AW Cheng, E Itskovich, S Markoulaki, K Ganz, ... Cell 150 (6), 1209-1222, 2012 | 978 | 2012 |
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations F Soldner, J Laganière, AW Cheng, D Hockemeyer, Q Gao, R Alagappan, ... Cell 146 (2), 318-331, 2011 | 941 | 2011 |
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development MM Dawlaty, K Ganz, BE Powell, YC Hu, S Markoulaki, AW Cheng, Q Gao, ... Cell stem cell 9 (2), 166-175, 2011 | 578 | 2011 |
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype IM Shapiro, AW Cheng, NC Flytzanis, M Balsamo, JS Condeelis, ... PLoS Genet 7 (8), e1002218-e1002218, 2011 | 511 | 2011 |
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development MM Dawlaty, A Breiling, T Le, G Raddatz, MI Barrasa, AW Cheng, Q Gao, ... Developmental cell 24 (3), 310-323, 2013 | 506 | 2013 |
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations CJ Lengner, AA Gimelbrant, JA Erwin, AW Cheng, MG Guenther, ... Cell 141 (5), 872-883, 2010 | 472 | 2010 |
Tet1 is critical for neuronal activity-regulated gene expression and memory extinction A Rudenko, MM Dawlaty, J Seo, AW Cheng, J Meng, T Le, KF Faull, ... Neuron 79 (6), 1109-1122, 2013 | 468 | 2013 |
Metastable pluripotent states in NOD-mouse-derived ESCs J Hanna, S Markoulaki, M Mitalipova, AW Cheng, JP Cassady, J Staerk, ... Cell stem cell 4 (6), 513-524, 2009 | 413 | 2009 |
CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells X Liu, Y Zhang, C Cheng, AW Cheng, X Zhang, N Li, C Xia, X Wei, X Liu, ... Cell Research, 2016 | 386 | 2016 |
Loss of Tet enzymes compromises proper differentiation of embryonic stem cells MM Dawlaty, A Breiling, T Le, MI Barrasa, G Raddatz, Q Gao, BE Powell, ... Developmental cell 29 (1), 102-111, 2014 | 362 | 2014 |
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ... Cell Stem Cell 13 (4), 446-458, 2013 | 355 | 2013 |
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts J Kim, SC Su, H Wang, AW Cheng, JP Cassady, MA Lodato, CJ Lengner, ... Cell stem cell 9 (5), 413-419, 2011 | 313 | 2011 |
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease W Qin, SL Dion, PM Kutny, Y Zhang, A Cheng, NL Jillette, A Malhotra, ... Genetics, genetics. 115.176594, 2015 | 293 | 2015 |
Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells D Maetzel, S Sarkar, H Wang, L Abi-Mosleh, P Xu, AW Cheng, Q Gao, ... Stem cell reports 2 (6), 866-880, 2014 | 247 | 2014 |