| The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway PM Sullivan, X Zhou, AM Robins, DH Paushter, D Kim, MB Smolka, F Hu Acta neuropathologica communications 4, 1-16, 2016 | 312 | 2016 |
| TGFβ signalling plays an important role in IL4-induced alternative activation of microglia X Zhou, B Spittau, K Krieglstein Journal of neuroinflammation 9, 1-14, 2012 | 185 | 2012 |
| Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin X Zhou, L Sun, F Bastos de Oliveira, X Qi, WJ Brown, MB Smolka, Y Sun, ... Journal of Cell Biology 210 (6), 991-1002, 2015 | 183 | 2015 |
| Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study C Pottier, X Zhou, RB Perkerson, M Baker, GD Jenkins, DJ Serie, ... The Lancet Neurology 17 (6), 548-558, 2018 | 113 | 2018 |
| Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations X Zhou, L Sun, O Bracko, JW Choi, Y Jia, AL Nana, OA Brady, ... Nature communications 8 (1), 15277, 2017 | 108 | 2017 |
| Endogenous transforming growth factor‐beta promotes quiescence of primary microglia in vitro B Spittau, L Wullkopf, X Zhou, J Rilka, D Pfeifer, K Krieglstein Glia 61 (2), 287-300, 2013 | 100 | 2013 |
| Regulation of cathepsin D activity by the FTLD protein progranulin X Zhou, DH Paushter, T Feng, CM Pardon, CS Mendoza, F Hu Acta neuropathologica 134, 151-153, 2017 | 71 | 2017 |
| Lysosomal processing of progranulin X Zhou, DH Paushter, T Feng, L Sun, T Reinheckel, F Hu Molecular neurodegeneration 12, 1-6, 2017 | 70 | 2017 |
| Progranulin deficiency leads to reduced glucocerebrosidase activity X Zhou, DH Paushter, MD Pagan, D Kim, M Nunez Santos, RL Lieberman, ... PLoS One 14 (7), e0212382, 2019 | 65 | 2019 |
| TGF β1 inhibits IFN γ‐mediated microglia activation and protects mDA neurons from IFN γ‐driven neurotoxicity X Zhou, T Zöller, K Krieglstein, B Spittau Journal of neurochemistry 134 (1), 125-134, 2015 | 52 | 2015 |
| Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a) OA Brady, X Zhou, F Hu Journal of Biological Chemistry 289 (28), 19670-19680, 2014 | 49 | 2014 |
| Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency X Zhou, L Sun, OA Brady, KA Murphy, F Hu Acta neuropathologica communications 5, 1-11, 2017 | 48 | 2017 |
| Expression of Tgfβ1 and inflammatory markers in the 6-hydroxydopamine mouse model of Parkinson’s disease SJP Haas, X Zhou, V Machado, A Wree, K Krieglstein, B Spittau Frontiers in molecular neuroscience 9, 7, 2016 | 47 | 2016 |
| Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies X Zhou, AM Nicholson, Y Ren, M Brooks, P Jiang, A Zuberi, HN Phuoc, ... Brain 143 (6), 1905-1919, 2020 | 46 | 2020 |
| IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration B Spittau, X Zhou, M Ming, K Krieglstein Neuromolecular medicine 14, 317-327, 2012 | 41 | 2012 |
| Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice X Zhou, M Brooks, P Jiang, S Koga, AR Zuberi, MC Baker, TM Parsons, ... EMBO reports 21 (10), e50197, 2020 | 36 | 2020 |
| The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C X Zhou, PM Sullivan, L Sun, F Hu Journal of neurochemistry 143 (2), 236-243, 2017 | 33 | 2017 |
| A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination T Feng, RR Sheng, S Solé-Domènech, M Ullah, X Zhou, CS Mendoza, ... Brain 143 (7), 2255-2271, 2020 | 32 | 2020 |
| Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency AE Arrant, AM Nicholson, X Zhou, R Rademakers, ED Roberson Molecular neurodegeneration 13, 1-12, 2018 | 28 | 2018 |
| Macrophages acquire fibroblast characteristics in a rat model of proliferative vitreoretinopathy M Lin, Y Li, Z Li, J Lin, X Zhou, D Liang Ophthalmic Research 45 (4), 180-190, 2011 | 28 | 2011 |
