Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus D Zabala, AF Braña, AB Flórez, JA Salas, C Méndez Metabolic engineering 20, 187-197, 2013 | 87 | 2013 |
Identification by genome mining of a type I polyketide gene cluster from Streptomyces argillaceus involved in the biosynthesis of pyridine and piperidine alkaloids argimycins P S Ye, B Molloy, AF Braña, D Zabala, C Olano, J Cortés, F Morís, JA Salas, ... Frontiers in Microbiology 8, 235379, 2017 | 43 | 2017 |
Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY AB Florez, S Alvarez, D Zabala, AF Brana, JA Salas, C Mendez Microbiology 161 (2), 272-284, 2015 | 28 | 2015 |
A Flavin-Dependent Decarboxylase–Dehydrogenase–Monooxygenase Assembles the Warhead of α, β-Epoxyketone Proteasome Inhibitors D Zabala, JW Cartwright, DM Roberts, BJC Law, L Song, M Samborskyy, ... Journal of the American Chemical Society 138 (13), 4342-4345, 2016 | 26 | 2016 |
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group S Zhou, L Song, J Masschelein, FAM Sumang, IA Papa, TO Zulaybar, ... ACS Chemical Biology 14 (6), 1305-1309, 2019 | 21 | 2019 |
Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains D Zabala, AF Braña, JA Salas, C Méndez The Journal of antibiotics 69 (3), 179-182, 2016 | 21 | 2016 |
Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin D Zabala, L Song, Y Dashti, GL Challis, JA Salas, C Méndez Microbial Cell Factories 19, 1-12, 2020 | 4 | 2020 |
Discovery and biosynthesis of persiathiacins: Unusual polyglycosylated thiopeptides active against multi-drug resistant tuberculosis Y Dashti, F Mohammadipanah, M Belousoff, A Vocat, D Zabala, CD Fage, ... bioRxiv, 2021.10. 24.465558, 2021 | 2 | 2021 |
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis C Huang, D Zabala, ELC De Los Santos, L Song, C Corre, LM Alkhalaf, ... Nucleic Acids Research 51 (3), 1488-1499, 2023 | 1 | 2023 |