Nirjal Mainali

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Robert J. Shmookler ReisProfessor, University of Arkansas for Medical SciencesVerified email at uams.edu
Srinivas AyyadevaraCentral Arkansas Healthcare System and University of Arkansas for Medical SciencesVerified email at uams.edu
Meenakshisundaram BalasubramaniamAssistant Professor, College of Medicine, University of Arkansas for Medical SciencesVerified email at uams.edu
Suresh Kuarm BowrojuAssociate Principal Scientist, Humanwell Pharmaceuticals, MOVerified email at humanwellus.com
Peter A. CrooksProfessor and Chair of Pharmaceutical Sciences, University of Arkansas for Medical SciencesVerified email at uams.edu
Akshatha GanneBioinformatics and Computational Biology, UALR/UAMSVerified email at uams.edu
Jawahar L MehtaUniversity of Arkansas for medical sciencesVerified email at uams.edu

Nirjal Mainali

Graduate Student, University of Arkansas for Medical Sciences

Verified email at ualr.edu

Bioinformatics Drug Discovery Alzheimer's disease Cardiovascular Research


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Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs M Balasubramaniam, N Mainali, SK Bowroju, P Atluri, NR Penthala, ... Scientific reports 10 (1), 18326, 2020	25	2020
Design and synthesis of novel hybrid 8-hydroxy quinoline-indole derivatives as inhibitors of Aβ self-aggregation and metal chelation-induced Aβ aggregation SK Bowroju, N Mainali, S Ayyadevara, NR Penthala, S Krishnamachari, ... Molecules 25 (16), 3610, 2020	13	2020
Protein homeostasis in the aged and diseased heart N Mainali, S Ayyadevara, A Ganne, RJS Reis, JL Mehta The journal of cardiovascular aging 3 (2), 2023	2	2023
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain N Mainali, X Li, X Wang, M Balasubramaniam, A Ganne, R Kore, ... Molecular and Cellular Biochemistry, 1-13, 2023	1	2023
Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan S Kakraba, S Ayyadevara, N Mainali, M Balasubramaniam, S Bowroju, ... Pharmaceuticals 16 (10), 1498, 2023	1	2023
Model biological systems demonstrate the inducibility of pathways that strongly reduce cryoprotectant toxicity A Mazur, S Ayyadevara, N Mainali, S Patchett, M Uden, RI Roa, GM Fahy, ... Cryobiology, 104881, 2024		2024
Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets M Balasubramaniam, A Ganne, N Mainali, S Pahal, S Ayyadevara, ... Iscience 27 (1), 2024		2024
Leave-one-out-analysis (LOOA): web-based tool to predict influential proteins and interactions in aggregate-crosslinking proteomic data N Mainali, M Balasubramaniam, J Johnson, S Ayyadevara, RJS Reis Bioinformation 20 (1), 4, 2024		2024
Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases Akshatha Ganne, Meenakshisundaram Balasubramaniam, Nirjal Mainali, Paavan ... International Journal of Molecular Sciences 23 (24), 20, 2022		2022

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