Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration R Langenbach, SG Morham, HF Tiano, CD Loftin, BI Ghanayem, ... Cell 83 (3), 483-492, 1995 | 1405 | 1995 |
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse SG Morham, R Langenbach, CD Loftin, HF Tiano, N Vouloumanos, ... Cell 83 (3), 473-482, 1995 | 1347 | 1995 |
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis HF Tiano, CD Loftin, J Akunda, CA Lee, J Spalding, A Sessoms, ... Cancer research 62 (12), 3395-3401, 2002 | 421 | 2002 |
Cyclooxygenase knockout mice: models for elucidating isoform-specific functions R Langenbach, C Loftin, C Lee, H Tiano Biochemical pharmacology 58 (8), 1237-1246, 1999 | 282 | 1999 |
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2 CD Loftin, DB Trivedi, HF Tiano, JA Clark, CA Lee, JA Epstein, ... Proceedings of the National Academy of Sciences 98 (3), 1059-1064, 2001 | 269 | 2001 |
Cyclooxygenase‐deficient mice: a summary of their characteristics and susceptibilities to inflammation and carcinogenesis R Langenbach, CD Loftin, C Lee, H Tiano Annals of the New York Academy of Sciences 889 (1), 52-61, 1999 | 212 | 1999 |
Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice VL King, DB Trivedi, JM Gitlin, CD Loftin Arteriosclerosis, thrombosis, and vascular biology 26 (5), 1137-1143, 2006 | 156 | 2006 |
Interleukin-1β–induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling T Gray, P Nettesheim, C Loftin, JS Koo, J Bonner, S Peddada, ... Molecular pharmacology 66 (2), 337-346, 2004 | 145 | 2004 |
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2 CD Loftin, HF Tiano, R Langenbach Prostaglandins & other lipid mediators 68, 177-185, 2002 | 145 | 2002 |
Expression and regulation of nonsteroidal anti-inflammatory drug–activated gene (NAG-1) in human and mouse tissue KS Kim, SJ Baek, GP Flake, CD Loftin, BF Calvo, TE Eling Gastroenterology 122 (5), 1388-1398, 2002 | 145 | 2002 |
Generation of a conditional allele of the mouse prostaglandin EP4 receptor A Schneider, YF Guan, Y Zhang, MA Magnuson, C Pettepher, CD Loftin, ... Genesis 40 (1), 7-14, 2004 | 107 | 2004 |
Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice JM Gitlin, DB Trivedi, R Langenbach, CD Loftin Cardiovascular research 73 (1), 227-236, 2007 | 100 | 2007 |
Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice S Ghoshal, DB Trivedi, GA Graf, CD Loftin Journal of Biological Chemistry 286 (1), 889-898, 2011 | 98 | 2011 |
Cyclooxygenase-1–selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus CD Loftin, DB Trivedi, R Langenbach The Journal of clinical investigation 110 (4), 549-557, 2002 | 93 | 2002 |
Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice JM Gitlin, CD Loftin Cardiovascular research 81 (2), 400-407, 2009 | 81 | 2009 |
Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin SL Banks, KS Paudel, NK Brogden, CD Loftin, AL Stinchcomb Pharmaceutical research 28, 1211-1219, 2011 | 74 | 2011 |
Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice ML Kelso, SW Scheff, JR Pauly, CD Loftin BMC neuroscience 10, 1-9, 2009 | 49 | 2009 |
Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs K Ding, Z Zhou, S Hou, Y Yuan, S Zhou, X Zheng, J Chen, C Loftin, ... Scientific reports 8 (1), 5205, 2018 | 47 | 2018 |
Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice S Ghoshal, CD Loftin PloS one 7 (11), e44369, 2012 | 40 | 2012 |
β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice DB Trivedi, CD Loftin, J Clark, P Myers, LM DeGraff, J Cheng, DC Zeldin, ... Circulation research 112 (9), 1219-1229, 2013 | 36 | 2013 |