Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes JL Gómez-Skarmeta, RD del Corral, E de la Calle-Mustienes, ... Cell 85 (1), 95-105, 1996 | 332 | 1996 |
Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis O Bogdanović, A Fernandez-Miñán, JJ Tena, E de la Calle-Mustienes, ... Genome research 22 (10), 2043-2053, 2012 | 247 | 2012 |
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3 A Ragvin, E Moro, D Fredman, P Navratilova, Ø Drivenes, PG Engström, ... Proceedings of the National Academy of Sciences 107 (2), 775-780, 2010 | 238 | 2010 |
A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts E De La Calle-Mustienes, CG Feijóo, M Manzanares, JJ Tena, ... Genome research 15 (8), 1061-1072, 2005 | 237 | 2005 |
Amphioxus functional genomics and the origins of vertebrate gene regulation F Marlétaz, PN Firbas, I Maeso, JJ Tena, O Bogdanovic, M Perry, ... Nature 564 (7734), 64-70, 2018 | 231 | 2018 |
Zebrafish enhancer detection (ZED) vector: A new tool to facilitate transgenesis and the functional analysis of cis‐regulatory regions in zebrafish J Bessa, JJ Tena, E de la Calle‐Mustienes, A Fernández‐Miñán, ... Developmental dynamics: an official publication of the American Association …, 2009 | 184 | 2009 |
Genome-wide profiling of p63 DNA–binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus EN Kouwenhoven, SJ van Heeringen, JJ Tena, M Oti, BE Dutilh, ... PLoS genetics 6 (8), e1001065, 2010 | 181 | 2010 |
Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders C Gómez-Marín, JJ Tena, RD Acemel, M López-Mayorga, S Naranjo, ... Proceedings of the National Academy of Sciences 112 (24), 7542-7547, 2015 | 166 | 2015 |
Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate JL Gómez‐Skarmeta, A Glavic, E de la Calle‐Mustienes, J Modolell, ... The EMBO journal, 1998 | 165 | 1998 |
Active DNA demethylation at enhancers during the vertebrate phylotypic period O Bogdanovic, AH Smits, E de la Calle Mustienes, JJ Tena, E Ford, ... Nature genetics 48 (4), 417-430, 2016 | 153 | 2016 |
Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints M Irimia, JJ Tena, MS Alexis, A Fernandez-Miñan, I Maeso, O Bogdanović, ... Genome research 22 (12), 2356-2367, 2012 | 142 | 2012 |
Odd-skipped genes encode repressors that control kidney development JJ Tena, A Neto, E de la Calle-Mustienes, C Bras-Pereira, F Casares, ... Developmental biology 301 (2), 518-531, 2007 | 141 | 2007 |
Deep conservation of wrist and digit enhancers in fish AR Gehrke, I Schneider, E De La Calle-Mustienes, JJ Tena, ... Proceedings of the National Academy of Sciences 112 (3), 803-808, 2015 | 136 | 2015 |
The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4 JL Gómez-Skarmeta, E Calle-Mustienes, J Modolell Development 128 (4), 551-560, 2001 | 135 | 2001 |
Active DNA demethylation at enhancers during the vertebrate phylotypic period O Bogdanović, AH Smits, E de la Calle Mustienes, JJ Tena, E Ford, ... Nature genetics 48 (4), 417-426, 2016 | 130 | 2016 |
A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation RD Acemel, JJ Tena, I Irastorza-Azcarate, F Marlétaz, C Gómez-Marín, ... Nature genetics 48 (3), 336-341, 2016 | 129 | 2016 |
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes D Martin, C Pantoja, AF Miñán, C Valdes-Quezada, E Moltó, F Matesanz, ... Nature structural & molecular biology 18 (6), 708-714, 2011 | 123 | 2011 |
An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation JJ Tena, ME Alonso, E de La Calle-Mustienes, E Splinter, W De Laat, ... Nature communications 2 (1), 310, 2011 | 85 | 2011 |
A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins J Letelier, E De La Calle-Mustienes, J Pieretti, S Naranjo, I Maeso, ... Nature genetics 50 (4), 504-509, 2018 | 76 | 2018 |
The emergence of the brain non-CpG methylation system in vertebrates A de Mendoza, D Poppe, S Buckberry, J Pflueger, CB Albertin, T Daish, ... Nature ecology & evolution 5 (3), 369-378, 2021 | 73 | 2021 |