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Josh Tycko
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Year
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
MR Mumbach, AJ Rubin, A Marson, A Kundaje, AT Satpathy, BG Gowen, ...
Nature genetics 49, 1602, 2017
4422017
Methods for optimizing CRISPR-Cas9 genome editing specificity
J Tycko, VE Myer, PD Hsu
Molecular cell 63 (3), 355-370, 2016
3312016
Lessons learned from the clinical development and market authorization of Glybera
LM Bryant*, DM Christopher*, AR Giles*, C Hinderer*, JL Rodriguez*, ...
Human gene therapy Clinical development 24 (2), 55-64, 2013
2652013
Methods and applications of CRISPR-mediated base editing in eukaryotic genomes
GT Hess*, J Tycko*, D Yao*, MC Bassik
Molecular cell 68 (1), 26-43, 2017
2552017
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
J Tycko*, M Wainberg*, GK Marinov*, O Ursu, GT Hess, BK Ego, A Li, ...
Nature communications 10 (1), 1-14, 2019
1012019
High-throughput discovery and characterization of human transcriptional effectors
J Tycko, N DelRosso, GT Hess, A Banerjee, A Mukund, MV Van, BK Ego, ...
Cell 183 (7), 2020
702020
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome
MG Durrant*, A Fanton*, J Tycko*, M Hinks, SS Chandrasekaran, ...
Nature Biotechnology, 1-12, 2022
572022
Large-scale mapping and mutagenesis of human transcriptional effector domains
N DelRosso, J Tycko, P Suzuki, C Andrews, Aradhana, A Mukund, ...
Nature 616 (7956), 365-372, 2023
38*2023
Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells
J Tycko, LA Barrera, NC Huston, AE Friedland, X Wu, JS Gootenberg, ...
Nature communications 9 (1), 3542, 2018
352018
Gene drives for schistosomiasis transmission control
T Maier, NJ Wheeler, EKO Namigai, J Tycko, RE Grewelle, ...
PLoS neglected tropical diseases 13 (12), e0007833, 2019
312019
The sound of silence: Transgene silencing in mammalian cell engineering
A Cabera*, HI Edelstein*, F Glykofrydis*, KS Love*, S Palacios*, J Tycko*, ...
Cell Systems 13 (12), 950-973, 2022
262022
Identification of guide-intrinsic determinants of Cas9 specificity
NC Huston, J Tycko, EL Tillotson, CJ Wilson, VE Myer, H Jayaram, ...
The CRISPR journal 2 (3), 172-185, 2019
222019
Toolbox for exploring modular gene regulation in Synthetic Biology training
MS Magaraci, JG Bermudez, D Yogish, DH Pak, V Mollov, J Tycko, ...
ACS synthetic biology 5 (7), 781-785, 2016
142016
Large-scale discovery of recombinases for integrating DNA into the human genome
MG Durrant*, A Fanton*, J Tycko*, M Hinks, SS Chandrasekaran, ...
BioRxiv, 2021
132021
Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology
J Tycko*, MV Van*, MB Elowitz, L Bintu
Current Opinion in Biomedical Engineering 4, 174-193, 2017
132017
High-throughput functional characterization of combinations of transcriptional activators and repressors
AX Mukund, J Tycko, SJ Allen, SA Robinson, C Andrews, J Sinha, ...
Cell Systems 14 (9), 746-763. e5, 2023
72023
A genome-wide genetic screen uncovers determinants of human pigmentation
VK Bajpai, T Swigut, J Mohammed, S Naqvi, M Arreola, J Tycko, TC Kim, ...
Science 381 (6658), eade6289, 2023
72023
CRISPR/CAS RELATED METHODS AND COMPOSITIONS FOR TREATING DUCHENNE MUSCLE DYSTROPHY
DA Bumcrot, NC Huston, JC Tycko, J Robinson-Hamm, CA Gersbach
72019
Crispr/Cas-Related Methods and Compositions for Treating Duchenne Muscular Dystrophy and Becker
PD Hsu, ML Maeder, P Odonnell, JC Tycko, NC Huston
US Patent App. 15/732,190, 2019
72019
Adeno-associated virus vector-mediated expression of antirespiratory syncytial virus antibody prevents infection in mouse airways
J Tycko, VS Adam, M Crosariol, J Ohlstein, J Sanmiguel, AP Tretiakova, ...
Human gene therapy 32 (23-24), 1450-1456, 2021
62021
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