| A functional role for adult hippocampal neurogenesis in spatial pattern separation CD Clelland, M Choi, C Romberg, GD Clemenson, A Fragniere, P Tyers, ... Science 325 (5937), 210-213, 2009 | 1919 | 2009 |
| α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, ... Nature communications 9 (1), 1-16, 2018 | 418 | 2018 |
| Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, ... Proceedings of the National Academy of Sciences 113 (9), E1206-E1215, 2016 | 216 | 2016 |
| Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, ... Cell Death & Differentiation, 1-16, 2020 | 185 | 2020 |
| Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS CE Hall, Z Yao, M Choi, GE Tyzack, A Serio, R Luisier, J Harley, E Preza, ... Cell reports 19 (9), 1739-1749, 2017 | 180 | 2017 |
| Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, ... Acta neuropathologica 137 (1), 103-120, 2019 | 128 | 2019 |
| Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II … BW Kim, M Choi, YS Kim, H Park, HR Lee, CO Yun, EJ Kim, JS Choi, ... Cellular signalling 20 (4), 714-725, 2008 | 127 | 2008 |
| Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases ML Choi, S Gandhi The FEBS journal 285 (19), 3631-3644, 2018 | 119 | 2018 |
| The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain L Choi, J Vernon, O Kopach, MS Minett, K Mills, PT Clayton, T Meert, ... Neuroscience letters 594, 163-168, 2015 | 108 | 2015 |
| Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity ML Choi, A Chappard, BP Singh, C Maclachlan, M Rodrigues, ... Nature neuroscience, 1-15, 2022 | 95 | 2022 |
| Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death C Hughes, ML Choi, JH Yi, SC Kim, A Drews, PS George-Hyslop, ... Communications biology 3 (1), 1-7, 2020 | 77 | 2020 |
| Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, ... BMC biology 15 (1), 57, 2017 | 76 | 2017 |
| Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein M Iljina, L Tosatto, ML Choi, JC Sang, Y Ye, CD Hughes, CE Bryant, ... Scientific reports 6, 33928, 2016 | 63 | 2016 |
| Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ... ChemBioChem 19 (19), 2033-2038, 2018 | 56 | 2018 |
| The impact of Type 2 diabetes in Parkinson's disease D Athauda, J Evans, A Wernick, G Virdi, ML Choi, M Lawton, ... Movement Disorders 37 (8), 1612-1623, 2022 | 46 | 2022 |
| Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease ML Choi, F Begeti, JH Oh, SY Lee, GC O'Keeffe, CD Clelland, P Tyers, ... Neurobiology of disease 66, 19-27, 2014 | 18 | 2014 |
| Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons GS Virdi, ML Choi, JR Evans, Z Yao, D Athauda, S Strohbuecker, ... npj Parkinson's Disease 8 (1), 1-22, 2022 | 17 | 2022 |
| A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain ML Choi, F Begeti, RA Barker, N Kim Hippocampus 26 (4), 517-529, 2016 | 8 | 2016 |
| Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease ML Choi, R Meleckyte, D Little, AY Abramov, R Patani, S Gandhi Free Radical Biology and Medicine 120, S162, 2018 | 6 | 2018 |
| Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models K D’Sa, JR Evans, GS Virdi, G Vecchi, A Adam, O Bertolli, J Fleming, ... Nature Machine Intelligence, 1-14, 2023 | 2 | 2023 |
Mathew HorrocksSenior Lecturer in Biophysics, School of Chemistry, University of EdinburghVerified email at ed.ac.uk
