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Oscar A Marcos-Contreras
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Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
JS Brenner, DC Pan, JW Myerson, OA Marcos-Contreras, CH Villa, ...
Nature communications 9 (1), 2684, 2018
2912018
Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin-and bradykinin-dependent mechanism
OA Marcos-Contreras, S Martinez de Lizarrondo, I Bardou, C Orset, ...
Blood, The Journal of the American Society of Hematology 128 (20), 2423-2434, 2016
1352016
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
OA Marcos-Contreras, CF Greineder, RY Kiseleva, H Parhiz, LR Walsh, ...
Proceedings of the National Academy of Sciences 117 (7), 3405-3414, 2020
1192020
Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes
M Gauberti, A Montagne, OA Marcos-Contreras, A Le Béhot, E Maubert, ...
Stroke 44 (7), 1988-1996, 2013
1162013
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation
S Zaitsev, D Spitzer, JC Murciano, BS Ding, S Tliba, MA Kowalska, ...
Blood, The Journal of the American Society of Hematology 115 (25), 5241-5248, 2010
1152010
Flexible nanoparticles reach sterically obscured endothelial targets inaccessible to rigid nanoparticles
JW Myerson, B Braender, O Mcpherson, PM Glassman, RY Kiseleva, ...
Advanced Materials 30 (32), 1802373, 2018
812018
Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation
JW Myerson, PN Patel, KM Rubey, ME Zamora, MH Zaleski, N Habibi, ...
Nature nanotechnology 17 (1), 86-97, 2022
632022
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)
H Parhiz, JS Brenner, PN Patel, TE Papp, H Shahnawaz, Q Li, R Shi, ...
Journal of Controlled Release 344, 50-61, 2022
572022
Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain
OA Marcos-Contreras, JS Brenner, RY Kiseleva, V Zuluaga-Ramirez, ...
Journal of controlled release 301, 54-61, 2019
402019
Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9
M Khoshnejad, JS Brenner, W Motley, H Parhiz, CF Greineder, CH Villa, ...
Scientific reports 8 (1), 1760, 2018
332018
The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo
G Pavani, L Ivanciu, A Faella, OA Marcos-Contreras, P Margaritis
Blood, The Journal of the American Society of Hematology 124 (7), 1157-1165, 2014
302014
Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII
OA Marcos-Contreras, SM Smith, DA Bellinger, RA Raymer, E Merricks, ...
Blood, The Journal of the American Society of Hematology 127 (5), 565-571, 2016
292016
Dual affinity to RBCs and target cells (DART) enhances both organ-and cell type-targeting of intravascular nanocarriers
LT Ferguson, ED Hood, T Shuvaeva, VV Shuvaev, MC Basil, Z Wang, ...
ACS nano 16 (3), 4666-4683, 2022
282022
Combating complement's deleterious effects on nanomedicine by conjugating complement regulatory proteins to nanoparticles
Z Wang, ED Hood, J Nong, J Ding, OA Marcos‐Contreras, PM Glassman, ...
Advanced Materials 34 (8), 2107070, 2022
262022
Cross-linker-modulated nanogel flexibility correlates with tunable targeting to a sterically impeded endothelial marker
JW Myerson, O McPherson, KG DeFrates, JH Towslee, ...
ACS nano 13 (10), 11409-11421, 2019
262019
Molecularly engineered nanobodies for tunable pharmacokinetics and drug delivery
PM Glassman, LR Walsh, CH Villa, OA Marcos-Contreras, ED Hood, ...
Bioconjugate chemistry 31 (4), 1144-1155, 2020
252020
Vascular endothelial effects of collaborative binding to platelet/endothelial cell adhesion molecule-1 (PECAM-1)
RY Kiseleva, CF Greineder, CH Villa, OA Marcos-Contreras, ED Hood, ...
Scientific Reports 8 (1), 1510, 2018
232018
Clot penetration and retention by plasminogen activators promote fibrinolysis
OA Marcos-Contreras, K Ganguly, A Yamamoto, R Shlansky-Goldberg, ...
Biochemical pharmacology 85 (2), 216-222, 2013
162013
Targeted in vivo loading of red blood cells markedly prolongs nanocarrier circulation
PM Glassman, CH Villa, OA Marcos-Contreras, ED Hood, LR Walsh, ...
Bioconjugate Chemistry 33 (7), 1286-1294, 2022
152022
Bivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo
RY Kiseleva, PG Glassman, KM LeForte, LR Walsh, CH Villa, VV Shuvaev, ...
FASEB journal: official publication of the Federation of American Societies …, 2020
122020
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