| The SARS-CoV-2 main protease as drug target S Ullrich, C Nitsche Bioorganic & medicinal chemistry letters 30 (17), 127377, 2020 | 665 | 2020 |
| Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor J Lei, G Hansen, C Nitsche, CD Klein, L Zhang, R Hilgenfeld Science 353 (6298), 503-505, 2016 | 366 | 2016 |
| Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir S Ullrich, KB Ekanayake, G Otting, C Nitsche Bioorganic & Medicinal Chemistry Letters 62, 128629, 2022 | 172 | 2022 |
| Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments C Jöst, C Nitsche, T Scholz, L Roux, CD Klein J. Med. Chem 57 (18), 7590-7599, 2014 | 165 | 2014 |
| Biochemistry and medicinal chemistry of the dengue virus protease C Nitsche, S Holloway, T Schirmeister, CD Klein Chemical reviews 114 (22), 11348-11381, 2014 | 154 | 2014 |
| The medicinal chemistry of dengue virus MAM Behnam, C Nitsche, V Boldescu, CD Klein Journal of medicinal chemistry 59 (12), 5622-5649, 2016 | 151 | 2016 |
| Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags C Nitsche, G Otting Elsevier, 2017 | 145 | 2017 |
| Thiazolidinone–peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture C Nitsche, VN Schreier, MAM Behnam, A Kumar, R Bartenschlager, ... Journal of Medicinal Chemistry 56 (21), 8389-8403, 2013 | 142 | 2013 |
| Peptide–boronic acid inhibitors of flaviviral proteases: medicinal chemistry and structural biology C Nitsche, L Zhang, LF Weigel, J Schilz, D Graf, R Bartenschlager, ... Journal of medicinal chemistry 60 (1), 511-516, 2017 | 138 | 2017 |
| Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases C Nitsche, C Steuer, CD Klein Bioorganic & medicinal chemistry 19 (24), 7318-7337, 2011 | 121 | 2011 |
| Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease C Nitsche, MAM Behnam, C Steuer, CD Klein Antiviral research 94 (1), 72-79, 2012 | 101 | 2012 |
| Phenylalanine and phenylglycine analogues as arginine mimetics in dengue protease inhibitors LF Weigel, C Nitsche, D Graf, R Bartenschlager, CD Klein Journal of medicinal chemistry 58 (19), 7719-7733, 2015 | 83 | 2015 |
| Inhibitors of the Zika virus protease NS2B-NS3 S Voss, C Nitsche Bioorganic & medicinal chemistry letters 30 (5), 126965, 2020 | 68 | 2020 |
| De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease C Nitsche, T Passioura, P Varava, M Mahawaththa, MM Leuthold, ... ACS Medicinal Chemistry Letters, 2019 | 65 | 2019 |
| C-terminal residue optimization and fragment merging: discovery of a potent peptide-hybrid inhibitor of dengue protease MAM Behnam, C Nitsche, SM Vechi, CD Klein ACS medicinal chemistry letters 5 (9), 1037-1042, 2014 | 64 | 2014 |
| NMR studies of ligand binding C Nitsche, G Otting Current opinion in structural biology 48, 16-22, 2018 | 61 | 2018 |
| Sensitive NMR approach for determining the binding mode of tightly binding ligand molecules to protein targets WN Chen, C Nitsche, KB Pilla, B Graham, T Huber, CD Klein, G Otting Journal of the American Chemical Society 138 (13), 4539-4546, 2016 | 56 | 2016 |
| Proteases from dengue, West Nile and Zika viruses as drug targets C Nitsche Biophysical reviews 11 (2), 157-165, 2019 | 55 | 2019 |
| Paramagnetic chemical probes for studying biological macromolecules Q Miao, C Nitsche, H Orton, M Overhand, G Otting, M Ubbink Chemical Reviews 122 (10), 9571-9642, 2022 | 54 | 2022 |
| Biocompatible macrocyclization between cysteine and 2-cyanopyridine generates stable peptide inhibitors C Nitsche, H Onagi, JP Quek, G Otting, D Luo, T Huber Organic letters 21 (12), 4709-4712, 2019 | 54 | 2019 |
Gottfried OttingProfessor of Structural Biology, The Australian National UniversityVerified email at anu.edu.au
